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Home >> Signaling Pathways >> Proteases >> Lipoxygenase

Lipoxygenase

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Targets for  Lipoxygenase

Products for  Lipoxygenase

  1. Cat.No. Product Name Information
  2. GC41136 8(S),15(S)-DiHETE 8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO. 8(S),15(S)-DiHETE Chemical Structure
  3. GC40382 8(S)-HEPE 8(S)-HEPE is a monohydroxy fatty acid produced by lipoxygenase oxidation of EPA. 8(S)-HEPE Chemical Structure
  4. GC40463 8(S)-HETE 8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. 8(S)-HETE Chemical Structure
  5. GC42619 8(S)-HETrE 8(S)-HETrE is a monohydroxy polyunsaturated fatty acid produced by rabbit neutrophil lipoxygenase when dihomo-γ-linolenic acid is used as a substrate. 8(S)-HETrE Chemical Structure
  6. GC40542 9(R)-HODE 9(R)-HODE is one of several monohydroxylated products of linoleic acid. 9(R)-HODE Chemical Structure
  7. GC40029 9(S),10(S),13(S)-TriHOME 9(S),10(S),13(S)-TriHOME is an oxylipin derived from linoleic acid. 9(S),10(S),13(S)-TriHOME Chemical Structure
  8. GC46753 9(S),12(S),13(S)-TriHOME An oxylipin 9(S),12(S),13(S)-TriHOME Chemical Structure
  9. GC40383 9(S)-HEPE 9(S)-HEPE is a monohydroxy fatty acid derived from EPA. 9(S)-HEPE Chemical Structure
  10. GC19460 9(S)-HODE 9(S)-HODE is produced by the lipoxygenation of linoleic acid in both plants and animals. 9(S)-HODE Chemical Structure
  11. GC40250 9(S)-HODE-d4 MaxSpec® Standard 9(S)-HODE-d4 is intended for use as an internal standard for the quantification of 9(S)-HODE by GC- or LC-mass spectrometry. 9(S)-HODE-d4 MaxSpec® Standard Chemical Structure
  12. GC42636 9(S)-HOTrE 9(S)-HOTrE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on α-linolenic acid. 9(S)-HOTrE Chemical Structure
  13. GC40357 9(S)-HpODE 9(S)-HpODE is produced by the action of arachidonate 5-LO on linoleic acid. 9(S)-HpODE Chemical Structure
  14. GC42637 9(S)-HpOTrE 9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid. 9(S)-HpOTrE Chemical Structure
  15. GC42651 9-oxo-10(E),12(E)-Octadecadienoic Acid 9-oxo-10(E),12(E)-Octadecadienoic acid (9-oxoODA) is a natural agonist, abundant in tomatoes, that activates PPARα at 10-20 μM. 9-oxo-10(E),12(E)-Octadecadienoic Acid Chemical Structure
  16. GC42653 9-OxoOTrE 9-OxoOTrE is produced by the oxidation of 9-HpOTrE. 9-OxoOTrE Chemical Structure
  17. GC45960 9c(i472) 9c(i472) is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 9c(i472) Chemical Structure
  18. GC31938 A-69412 A-69412 is a reversible, specific inhibitor of the 5-lipoxygenase (5-LO). A-69412 Chemical Structure
  19. GC46798 Adapalene-d3 An internal standard for the quantification of adapalene Adapalene-d3 Chemical Structure
  20. GC41211 Anacardic Acid Diene Anacardic acid diene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid. Anacardic Acid Diene Chemical Structure
  21. GC41531 Anacardic Acid Triene Anacardic acid triene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid. Anacardic Acid Triene Chemical Structure
  22. GC35425 Atreleuton A 5-LO inhibitor Atreleuton Chemical Structure
  23. GC32035 AZD 4407 (ZD 4407) AZD 4407 (ZD 4407) is a potent 5-lipoxygenase inhibitor. AZD 4407 (ZD 4407) Chemical Structure
  24. GC45951 BLX3887 A 15-LO-1 inhibitor BLX3887 Chemical Structure
  25. GC32002 Bunaprolast (U66858) Bunaprolast (U66858) (U66858) is a potent inhibitor of LTB4 production in human whole blood. Bunaprolast (U66858) Chemical Structure
  26. GC46105 Butyrolactone II A fungal metabolite Butyrolactone II Chemical Structure
  27. GN10792 Caffeic acid Caffeic acid Chemical Structure
  28. GC48893 Carbazomycin B A bacterial metabolite with diverse biological activities Carbazomycin B Chemical Structure
  29. GC48850 Carbazomycin C A bacterial metabolite with diverse biological activities Carbazomycin C Chemical Structure
  30. GC43153 CAY10416 Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 Chemical Structure
  31. GC41044 CAY10583

    Leukotriene B4 (LTB4) promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, superoxide anion production, chemotaxis, and chemokinesis.

     CAY10583 Chemical Structure
  32. GC18688 CAY10589 Microsomal Prostaglandin E2 Synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever and pain. CAY10589 Chemical Structure
  33. GC18877 CAY10606 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 Chemical Structure
  34. GC18480 CAY10649 5-Lipoxygenase (5-LO) catalyzes the biosynthesis of leukotrienes, which are involved in a variety of inflammatory responses, including neutrophil chemotaxis, vascular permeability, and smooth muscle contraction. CAY10649 Chemical Structure
  35. GC43194 CAY10698 Platelet-type 12-lipoxygenase catalyzes the formation of 12-HpETE from arachidonic acid. CAY10698 Chemical Structure
  36. GC49758 CAY10788 A CysLT1 receptor antagonist CAY10788 Chemical Structure
  37. GC31707 Chebulagic acid Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid Chemical Structure
  38. GC31235 Cirsiliol A flavonoid with diverse biological activities Cirsiliol Chemical Structure
  39. GC18728 CJ-13610 CJ-13610 is an inhibitor of 5-lipoxygenase (5-LO) that inhibits 5-LO product formation in human polymorphonuclear leukocytes (PMNLs) challenged with A23187 in vitro (IC50 = 70 nM). CJ-13610 Chemical Structure
  40. GC33905 CMI-392 CMI-392 is a dual 5-lipoxygenese inhibitor and platelet-activating factor (PAF) receptor antagonist with IC50s of 100 and 10 nM, respectively. CMI-392 Chemical Structure
  41. GC31961 CMI977 (LDP977) CMI977 (LDP977) is a potent 5-Lipoxygenase (5-LO) inhibitor. CMI977 (LDP977) Chemical Structure
  42. GC31967 COX/5-LO-IN-1 COX/5-LO-IN-1 (Atreleuton analog) is an inhibitor of cylooxygenase and 5-lipoxygenase (5-LO), used for the research of inflammatory and allergic disease states. COX/5-LO-IN-1 Chemical Structure
  43. GC40697 DDA DDA is a lipid peroxidation product of linolieic acid. DDA Chemical Structure
  44. GC43453 Diflapolin Diflapolin is a dual inhibitor of 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH). Diflapolin Chemical Structure
  45. GC43459 Dihydro Montelukast Dihydro montelukast is a potential impurity found in commercial montelukast preparations. Dihydro Montelukast Chemical Structure
  46. GC31940 Docebenone (AA 861) Docebenone (AA 861) (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. Docebenone (AA 861) Chemical Structure
  47. GC49590 Docosahexaenoic Acid 1,2,3,4-13C An internal standard for the quantification of DHA Docosahexaenoic Acid 1,2,3,4-13C Chemical Structure
  48. GC31801 Enazadrem Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities. Enazadrem Chemical Structure
  49. GC43616 EOS (d18:1/32:1/18:2) EOS is a ceramide found in the outer layer of the epidermis in mammals. EOS (d18:1/32:1/18:2) Chemical Structure
  50. GC49778 Etheroleic Acid A divinyl ether oxylipin Etheroleic Acid Chemical Structure
  51. GC47312 Etherolenic Acid A divinyl ether oxylipin Etherolenic Acid Chemical Structure
  52. GC47323 Etofenamate-d4 An internal standard for the quantification of etofenamate Etofenamate-d4 Chemical Structure
  53. GC49696 FPL 55712 (sodium salt) A leukotriene receptor antagonist FPL 55712 (sodium salt) Chemical Structure
  54. GC39013 FPL 62064 FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 Chemical Structure
  55. GC31947 ICI 211965 (ZM-211965) ICI 211965 (ZM-211965) (ZM-211965) is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor. ICI 211965 (ZM-211965) Chemical Structure
  56. GC12661 Indirubin-3'-oxime Indirubin-3'-oxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 μM, respectively; Indirubin-3'-oxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM. Indirubin-3'-oxime Chemical Structure
  57. GC40840 Leukotriene A3 methyl ester Biosynthesis of LTA3 occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway and it is the putative intermediate in the biosynthesis of 3-series leukotrienes. Leukotriene A3 methyl ester Chemical Structure
  58. GC18835 Leukotriene A4 methyl ester Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. Leukotriene A4 methyl ester Chemical Structure
  59. GC40278 Leukotriene B3 LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. Leukotriene B3 Chemical Structure
  60. GC44052 Leukotriene B4 dimethyl amide LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. Leukotriene B4 dimethyl amide Chemical Structure
  61. GC44053 Leukotriene B4 Ethanolamide The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. Leukotriene B4 Ethanolamide Chemical Structure
  62. GC40631 Leukotriene B4-3-aminopropylamide The effects of leukotriene B4 (LTB4) are mediated by two receptors, BLT1 and BLT2. Leukotriene B4-3-aminopropylamide Chemical Structure
  63. GC47556 Leukotriene B4-d4 A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Leukotriene B4-d4 Chemical Structure
  64. GC49597 Leukotriene B4-d5 An internal standard for the quantification of LTB4 Leukotriene B4-d5 Chemical Structure
  65. GC41107 Leukotriene B5 Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities. Leukotriene B5 Chemical Structure
  66. GC44054 Leukotriene C4 methyl ester Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. Leukotriene C4 methyl ester Chemical Structure
  67. GC47559 Leukotriene D4-d5 A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Leukotriene D4-d5 Chemical Structure
  68. GC47560 Leukotriene E4-d5 A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Leukotriene E4-d5 Chemical Structure
  69. GC18845 Leukotriene F4

    LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo.

     Leukotriene F4 Chemical Structure
  70. GC38196 Licofelone A dual inhibitor of COX1/COX2 and 5LO Licofelone Chemical Structure
  71. GC18552 Lipoxin A4

    A trihydroxy fatty acid containing a conjugated tetraene

     Lipoxin A4 Chemical Structure
  72. GC18680 Lipoxin A4 methyl ester

    Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4.

     Lipoxin A4 methyl ester Chemical Structure
  73. GC47569 Lipoxin A4-d5 A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Lipoxin A4-d5 Chemical Structure
  74. GC40609 Lipoxin A5 Lipoxin A5 (LXA5) is produced by enzymatic transformation of EPA by leukocytes. Lipoxin A5 Chemical Structure
  75. GC18681 Lipoxin B4 Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes. Lipoxin B4 Chemical Structure
  76. GC47570 Lipoxygenin An inhibitor of 5-LO Lipoxygenin Chemical Structure
  77. GC31978 Lonapalene (RS4317) Lonapalene (RS4317) (RS4317) is a topically effective 5-lipoxygenase (5-LO) inhibitor. Lonapalene (RS4317) Chemical Structure
  78. GC47575 Loratadine-d5 An internal standard for the quantification of loratadine Loratadine-d5 Chemical Structure
  79. GC33907 LP117 LP117 is a novel and potent inhibitor of 5-Lipoxygenase (5-LO) product synthesis with an IC50 of 1.1 μM. LP117 Chemical Structure
  80. GC30610 LY 178002

    LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

     LY 178002 Chemical Structure
  81. GC36516 Lycopodine Lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatumspores, triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in refractory prostate cancer cells without modulating p53 activity. Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine Chemical Structure
  82. GC14751 Malotilate Stimulates hepatocyte regeneration Malotilate Chemical Structure
  83. GC40980 Maresin 2

    Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.

     Maresin 2 Chemical Structure
  84. GC44138 MCTR1 Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. MCTR1 Chemical Structure
  85. GC44139 MCTR2 Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. MCTR2 Chemical Structure
  86. GC44140 MCTR3 Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages. MCTR3 Chemical Structure
  87. GC44212 MK-886 (sodium salt) Arachidonic acid and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO). MK-886 (sodium salt) Chemical Structure
  88. GC36628 ML355 ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties. ML355 Chemical Structure
  89. GC52105 Montelukast Montelukast (MK0476 free base) is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast Chemical Structure
  90. GC47716 Myxochelin A A microbial metabolite with diverse biological activities Myxochelin A Chemical Structure
  91. GC44295 N-acetyl Leukotriene E4 N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. N-acetyl Leukotriene E4 Chemical Structure
  92. GC44415 N-methyl Leukotriene C4

    Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4.

     N-methyl Leukotriene C4 Chemical Structure
  93. GC18089 Nordihydroguaiaretic acid A non-selective LO inhibitor Nordihydroguaiaretic acid Chemical Structure
  94. GC49098 Olsalazine-13C6 An internal standard for the quantification of olsalazine Olsalazine-13C6 Chemical Structure
  95. GC44579 PCTR1 Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid. PCTR1 Chemical Structure
  96. GC44580 PCTR2 Protein conjugates in tissue regeneration 2 (PCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid. PCTR2 Chemical Structure
  97. GC44581 PCTR3 Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid. PCTR3 Chemical Structure
  98. GC36883 PF-4191834 PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM), displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain. PF-4191834 Chemical Structure
  99. GC32038 PGS-IN-1 (KME-4) PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM. PGS-IN-1 (KME-4) Chemical Structure
  100. GC61180 Phenidone Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone Chemical Structure
  101. GC40981 Protectin D1 Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid. Protectin D1 Chemical Structure

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