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Home >> Signaling Pathways >> Proteases >> MMP

MMP

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.

Products for  MMP

  1. Cat.No. Product Name Information
  2. GC41552 ω-3 Arachidonic Acid

    ω3 AA

     ω-3 Arachidonic acid is a rare PUFA found in trace amounts in dietary sources. ω-3 Arachidonic Acid Chemical Structure
  3. GC40229 (±)-Warfarin-d5 (±)-Warfarin-d5 is intended for use as an internal standard for the quantification of warfarin by GC- or LC-MS. (±)-Warfarin-d5 Chemical Structure
  4. GC17242 (-)-epigallocatechin

    (-)EGC, epi-Gallocatechin, NSC 674039

     green tea epicatechin (-)-epigallocatechin Chemical Structure
  5. GN10783 (R) Ginsenoside Rh2 (R) Ginsenoside Rh2 Chemical Structure
  6. GC64535 (S,S)-TAPI-1

    TAPI

     (S,S)-TAPI-1 is an isomer of TAPI-1. (S,S)-TAPI-1 Chemical Structure
  7. GC45978 1,10-Phenanthroline (hydrate)

    o-Phenanthroline

     o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. 1,10-Phenanthroline (hydrate) Chemical Structure
  8. GC41776 1,2,3-Trioleoyl-rac-glycerol

    Glyceryl Trioleate, TG(18:1/18:1/18:1), Triolein

     1,2,3-Trioleoyl-rac-glycerol is a symmetrical triacylglycerol, reduces MMP-1 upregulation, with strong antioxidant and anti-inflammatory properties. 1,2,3-Trioleoyl-rac-glycerol Chemical Structure
  9. GC45341 4-Amino-6-chloro-1,3-benzenedisulfonamide

    ACB, Chloraminophenamide, 3-Chloroaniline-4,6-disulfonamide, NSC 93772

       4-Amino-6-chloro-1,3-benzenedisulfonamide Chemical Structure
  10. GC18359 4-Epianhydrochlortetracycline (hydrochloride) 4-Epianhydrochlortetracycline is a derivative of tetracycline . 4-Epianhydrochlortetracycline (hydrochloride) Chemical Structure
  11. GC41642 9(E),11(E),13(E)-Octadecatrienoic Acid

    β-Eleostearic Acid, β-ESA

     9(E),11(E),13(E)-Octadecatrienoic acid (β-ESA) is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid. 9(E),11(E),13(E)-Octadecatrienoic Acid Chemical Structure
  12. GC42665 AAF-CMK (trifluoroacetate salt)

    NAlaAlaPheCMK, Tripeptidyl Peptidase Inhibitor II

     Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK (trifluoroacetate salt) Chemical Structure
  13. GC46769 Abametapir

    5,5′-Dimethyl-2,2′-dipyridyl

     A building block and an insecticide Abametapir Chemical Structure
  14. GC46779 Acequinocyl A naphthoquinone acaricide Acequinocyl Chemical Structure
  15. GC16350 Actinonin

    (-)-Actinonin,Ro 06-1467

    Peptidomimetic antibiotic that inhibits aminopeptidases

     Actinonin Chemical Structure
  16. GC71415 Aderamastat Aderamastat (FP-025) is an orally active matrix metalloproteinase 12 (MMP-12) inhibitor. Aderamastat Chemical Structure
  17. GC63661 Aderbasib Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2+?breast cancer, gliomas, et al. Aderbasib Chemical Structure
  18. GC46820 AHU377-d4

    Sacubitril-d4

     AHU377-d4 (AHU-377-d4) is the deuterium labeled Sacubitril. AHU377-d4 Chemical Structure
  19. GC35300 Aloin(mixture of A&B) Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin(mixture of A&B) Chemical Structure
  20. GP10057 Amyloid β-Peptide (10-20) (human)

    Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe

    Amyloid β-Peptide (10-20) (human) Chemical Structure
  21. GC46854 Anastrozole-d12

    Anastrol-d12

     An internal standard for the quantification of anastrozole Anastrozole-d12 Chemical Structure
  22. GC68656 Andecaliximab

    Anti-MMP9 Reference Antibody (andecaliximab)

    Andecaliximab is a recombinant IgG4 monoclonal antibody that targets matrix metalloproteinase 9 (MMP9). Andecaliximab has demonstrated anti-fibrotic efficacy in a mouse model of idiopathic pulmonary fibrosis. Andecaliximab can be used for research on gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF).

     Andecaliximab Chemical Structure
  23. GC48509 Apigenin 7-O-Glucuronide (hydrate) Apigenin 7-O-Glucuronide (hydrate) Chemical Structure
  24. GC35369 Apigenin-7-glucuronide Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively. Apigenin-7-glucuronide Chemical Structure
  25. GC35377 Apratastat

    TMI-005

     An inhibitor of ADAM17 and MMPs Apratastat Chemical Structure
  26. GN10063 Arctigenin Arctigenin,a natural lignan compound,has demonstrated anticancer activities in cancer. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin Chemical Structure
  27. GC13487 ARP 100

    CAY10609, Matrix Metalloproteinase-2 Inhibitor III, MMP2 Inhibitor III

     A selective inhibitor of MMP-2 ARP 100 Chemical Structure
  28. GC12465 ARP 101 ARP 101 Chemical Structure
  29. GN10494 Astragaloside IV

    AS-IV, AST-IV

     Astragaloside IV, an active component isolated from Astragalus membranaceus, can protect the myocardium against ischemia/reperfusion injury and Inhibits HAdV-3 replication and reduces HAdV-3-induced apoptosis. Astragaloside IV Chemical Structure
  30. GC46890 Atorvastatin-d5 (calcium salt) An internal standard for the quantification of atorvastatin Atorvastatin-d5 (calcium salt) Chemical Structure
  31. GC42873 Auraptene

    7Geranyloxycoumarin

     Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. Auraptene Chemical Structure
  32. GC16530 Batimastat (BB-94)

    BB-94

     A potent broad spectrum inhibitor of MMPs Batimastat (BB-94) Chemical Structure
  33. GC35470 Batimastat sodium salt Batimastat sodium salt is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively. Batimastat sodium salt Chemical Structure
  34. GC74024 BPU BPU arrests cell cycle progression in the sub-G1 phase. BPU Chemical Structure
  35. GC32442 BR351 BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively. BR351 Chemical Structure
  36. GC33365 BR351 precursor BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively. BR351 precursor Chemical Structure
  37. GC43050 C18 L-erythro Ceramide (d18:1/18:0)

    L-erythro Cer(d18:1/18:0), L-erythro Ceramide (d18:1/18:0), N-octadecanoyl-L-erythro-Sphingosine

     C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide. C18 L-erythro Ceramide (d18:1/18:0) Chemical Structure
  38. GC43051 C18 L-threo Ceramide (d18:1/18:0)

    N-octadecanoyl-L-threo-Sphingosine, L-threo Cer(d18:1/18:0), L-threo Ceramide (d18:1/18:0)

     C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. C18 L-threo Ceramide (d18:1/18:0) Chemical Structure
  39. GC43114 Caffeic Acid-13C3 Caffeic acid-13C3 is an isotopically enriched form of caffeic acid that is intended for use as an internal standard for the quantification of caffeic acid by GC- or LC-MS. Caffeic Acid-13C3 Chemical Structure
  40. GC45398 Captopril-d3   Captopril-d3 Chemical Structure
  41. GC47042 Carfilzomib-d8 An internal standard for the quantification of carfilzomib Carfilzomib-d8 Chemical Structure
  42. GC43146 Caspase-9 Inhibitor III (trifluoroacetate salt)

    Ac-LEHD-CMK

     Caspase-9 inhibitor III is an inhibitor of caspase-9 with cardioprotective effects. Caspase-9 Inhibitor III (trifluoroacetate salt) Chemical Structure
  43. GC43188 CAY10680 CAY10680 is a dopamine-sparing, benzothiazinone compound that selectively inhibits both MAO-B activity (IC50 = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.5 nM in human). CAY10680 Chemical Structure
  44. GC48416 Chlorhexidine-d8 (hydrochloride)

    CHX-d8

     An internal standard for the quantification of chlorhexidine Chlorhexidine-d8 (hydrochloride) Chemical Structure
  45. GN10342 Chondroitin sulfate (from bovine)

    Chondroitin polysulfate sulfate (from bovine)

    Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis.

     Chondroitin sulfate (from bovine) Chemical Structure
  46. GC10149 cis-ACCP type IV collagen-specific MMP-2 and MMP-9 inhibitor cis-ACCP Chemical Structure
  47. GC15952 CL 82198 hydrochloride An inhibitor of MMP-13 CL 82198 hydrochloride Chemical Structure
  48. GC26385 CL-82198

    CL-82198 is a selective inhibitor of MMP-13. 

     CL-82198 Chemical Structure
  49. GC62347 CMC2.24

    TRB-N0224

     CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 Chemical Structure
  50. GC47117 Colchicine-d6

    An internal standard for the quantification of colchicine

     Colchicine-d6 Chemical Structure
  51. GN10810 Cordycepin

    3'Deoxyadenosine, NSC 63984, NSC 401022

     Cordycepin (3’-deoxyadenosine) is a nucleoside analog that inhibits polyadenylation. Cordycepin Chemical Structure
  52. GC12157 CP 471474 A broad-spectrum MMP inhibitor CP 471474 Chemical Structure
  53. GC18144 CTS-1027

    Ro 113-0830, RS 130830

     An inhibitor of MMPs CTS-1027 Chemical Structure
  54. GC35754 CTTHWGFTLC, CYCLIC CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. CTTHWGFTLC, CYCLIC Chemical Structure
  55. GC60114 CTTHWGFTLC, CYCLIC TFA CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. CTTHWGFTLC, CYCLIC TFA Chemical Structure
  56. GC68925 cyclo(RLsKDK) TFA

    BK-1361 TFA

    cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) is a specific inhibitor of the metalloproteinase ADAM8, with an IC50 value of 182 nM. It has potential applications in inflammatory diseases and cancer.

     cyclo(RLsKDK) TFA Chemical Structure
  57. GC33330 Cynaropicrin A sesquiterpene lactone Cynaropicrin Chemical Structure
  58. GC18709 D-NMMA (acetate)

    D-NG-monomethyl Arginine Acetate

     D-NMMA is the inactive enantiomer of the competitive NOS inhibitor, L-NMMA . D-NMMA (acetate) Chemical Structure
  59. GC15206 DC_AC50 Selective Atox1 and CCS inhibitor DC_AC50 Chemical Structure
  60. GC40538 Decylubiquinone

    Decylubiquinone is an analog of ubiquinone.

     Decylubiquinone Chemical Structure
  61. GC18517 Diapocynin Diapocynin is the dimeric form of the NADPH oxidase inhibitor apocynin that has anti-inflammatory and antioxidant activities. Diapocynin Chemical Structure
  62. GC63621 Doxycycline Doxycycline is a tetracycline-derivative wide-spectrum antibiotic, inhibit protein synthesis by interfering with the binding of activated aminoacyl-tRNAs on the A-site of the 30S subunit of bacterial ribosomes. Doxycycline Chemical Structure
  63. GC13750 Doxycycline HCl Doxycycline HCl, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline HCl Chemical Structure
  64. GC13456 Doxycycline hyclate Doxycycline hyclate is a derivative of tetracycline and possesses the activities of anti-inflammatory and antimicrobial. Doxycycline hyclate Chemical Structure
  65. GC45440 Doxycycline-d3 (hyclate)

     An internal standard for quantifying doxycycline

     Doxycycline-d3 (hyclate) Chemical Structure
  66. GC12838 Edaravone

    Edaravone, NSC 2629

     A radical scavenger and antioxidant Edaravone Chemical Structure
  67. GC62948 Edaravone D5

    MCI-186-d5

     Edaravone D5 is a deuterium labeled Edaravone. Edaravone D5 Chemical Structure
  68. GC47326 Etoxazole An organofluorine acaricide Etoxazole Chemical Structure
  69. GC47339 Fenpropimorph

    BAS 42100F

     A fungicide that inhibits the sterol pathway Fenpropimorph Chemical Structure
  70. GC47351 Fingolimod-d4 An internal standard for the quantification of fingolimod Fingolimod-d4 Chemical Structure
  71. GC47366 Flurbiprofen-d3 An internal standard for the quantification of flurbiprofen Flurbiprofen-d3 Chemical Structure
  72. GC70201 FN-439 TFA FN-439 TFA is a selective collagenase-1 inhibitor. FN-439 TFA Chemical Structure
  73. GC60860 FSL-1 TFA

    FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.

     FSL-1 TFA Chemical Structure
  74. GC43725 Gallocyanine

    IIIC3, Alizarine Navy Blue, Anthracene Blue SWGG, Brilliant Chrome Blue P, C.I. 51030, Fast Violet, Mordant Blue 10

     Gallocyanine, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction. Gallocyanine Chemical Structure
  75. GC14578 GI 254023X

    GI 4023, SRI 028594

     An ADAM10 inhibitor GI 254023X Chemical Structure
  76. GN10473 Ginkgolide C

    BN 52022, 1,7-dihydroxy Ginkgolide A

     Ginkgolide C Chemical Structure
  77. GC36137 Ginsenoside F4 Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 Chemical Structure
  78. GC43780 GM 1489 GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. GM 1489 Chemical Structure
  79. GC14523 GM 6001

    Galardin, Ilomastat

    GM 6001 is a broad-spectrum MMP inhibitor that can be used in the study of cancer and neurodegenerative diseases. The Ki values of GM 6001 for MMP-1, 2, 3, 8 and 9 are 0.4, 0.5, 27, 0.1 and 0.2 nM, respectively.

     GM 6001 Chemical Structure
  80. GC39640 GPLGIAGQ TFA GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT). GPLGIAGQ TFA Chemical Structure
  81. GC48421 GW 280264X An ADAM17/TACE and ADAM10 inhibitor GW 280264X Chemical Structure
  82. GC72231 Hepcidin-1 (mouse) (TFA) Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) (TFA) Chemical Structure
  83. GC31898 Histatin 5 Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. Histatin 5 Chemical Structure
  84. GC36230 Histatin 5 (TFA) Histatin 5 (TFA) Chemical Structure
  85. GC72971 INCB3619 INCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 Chemical Structure
  86. GC32823 Incyclinide (CMT-3)

    CMT-3, COL-3, NSC 683551

     Incyclinide (CMT-3) (CMT-3, COL-3) is a matrix metalloproteinase (MMP) inhibitor, thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. Incyclinide (CMT-3) Chemical Structure
  87. GC43912 Isoapoptolidin Isoapoptolidin is a stable derivative of apoptolidin that demonstrates 10-fold reduced F1FO-ATP synthase inhibitory activity compared to apoptolidin (IC50s = 17 and 0.7 μM, respectively). Isoapoptolidin Chemical Structure
  88. GC39134 Isofraxidin Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin Chemical Structure
  89. GC32758 Isoginkgetin A biflavonoid inhibitor of pre-mRNA splicing Isoginkgetin Chemical Structure
  90. GC39095 Isoliquiritin apioside Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells. Isoliquiritin apioside Chemical Structure
  91. GC49142 Isorhoifolin

    Apigenin-7-O-rutinoside

     A flavonoid glycoside with diverse biological activities Isorhoifolin Chemical Structure
  92. GC32792 JNJ0966 An inhibitor of MMP-9 zymogen activation JNJ0966 Chemical Structure
  93. GC17702 K-Ras(G12C) inhibitor 9 allosteric inhibitor of oncogenic K-Ras(G12C) K-Ras(G12C) inhibitor 9 Chemical Structure
  94. GC36456 Licoricidin Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin Chemical Structure
  95. GC36489 Lucidenic acid C Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells. Lucidenic acid C Chemical Structure
  96. GC36491 Lucideric acid A

    Lucideric Acid A, Lucidenic Acid α

     A triterpene with anticancer activity Lucideric acid A Chemical Structure
  97. GC36495 Luteolin 7-O-glucuronide

    Luteolin-7-O-β-D-glucuronide

     A flavone with diverse biological activities Luteolin 7-O-glucuronide Chemical Structure
  98. GC14099 Marimastat

    BB-2516, KB-R8898

     A broad-spectrum inhibitor of MMPs and TACE Marimastat Chemical Structure
  99. GC72202 Mca-PLAQAV-Dpa-RSSSR-NH2 TFA Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE); ADAM17, ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 TFA Chemical Structure
  100. GC47646 Methiocarb

    Mercaptodimethur, 4-Methylthio-3,5-dimethylphenyl methylcarbamate, BAY 37344

     A carbamate pesticide Methiocarb Chemical Structure
  101. GC47647 Methiocarb-d3

    Mercaptodimethur-d3, 4-Methylthio-3,5-dimethylphenyl methylcarbamate-d3

     An internal standard for the quantification of methiocarb Methiocarb-d3 Chemical Structure

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