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MMP

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.

Products for  MMP

  1. Cat.No. Product Name Information
  2. GC40624 MMP-3 Inhibitor VIII Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. MMP-3 Inhibitor VIII  Chemical Structure
  3. GC18616 MMP-8 Inhibitor I MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. MMP-8 Inhibitor I  Chemical Structure
  4. GC44237 MMP-9 Inhibitor I MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). MMP-9 Inhibitor I  Chemical Structure
  5. GC38929 MMP-9-IN-1 MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, whichselectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs. MMP-9-IN-1  Chemical Structure
  6. GC18612 MMP-9/MMP-13 Inhibitor I MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both). MMP-9/MMP-13 Inhibitor I  Chemical Structure
  7. GC65957 MMP13-IN-2 MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 (IC50=0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1, 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease research. MMP13-IN-2  Chemical Structure
  8. GC63322 MMP13-IN-3 MMP13-IN-3 is a potent, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis. MMP13-IN-3  Chemical Structure
  9. GC36635 MMP3 inhibitor 1 MMP3 inhibitor 1 is a potent and highly selective MMP-3 inhibitor with an IC50 of 1 nM. MMP3 inhibitor 1  Chemical Structure
  10. GN10360 Morroniside Morroniside  Chemical Structure
  11. GC19483 MS-PPOH Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway. MS-PPOH   Chemical Structure
  12. GC47712 Mycophenolate Mofetil-d4 An internal standard for the quantification of mycophenolate mofetil Mycophenolate Mofetil-d4  Chemical Structure
  13. GC44306 N-acetyl-S-geranylgeranyl-L-Cysteine N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). N-acetyl-S-geranylgeranyl-L-Cysteine  Chemical Structure
  14. GC44441 N-Oleoyl Leucine N-Oleoyl leucine is an N-acyl amide generated by PM20D1 that uncouples mitochondrial respiration independent of uncoupling protein 1 (UCP1) in vitro. N-Oleoyl Leucine  Chemical Structure
  15. GC44341 ND-336 ND-336 is a selective inhibitor of the gelatinases matrix metalloproteinase-2 (MMP-2) and MMP-9, as well as MMP-14 (Kis = 85, 150, and 120 nM, respectively). ND-336  Chemical Structure
  16. GC69554 NFF-3 TFA

    NFF-3 TFA peptide is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 and is hydrolyzed by them. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. By labeling NFF-3 TFA with CyDye Cy3/Cy5Q, fluorescence can be generated in cell experiments to detect cellular activity.

    NFF-3 TFA  Chemical Structure
  17. GC15726 NNGH cell-permeable, broad-spectrum inhibitor of MMPs NNGH  Chemical Structure
  18. GC44431 nNOS Inhibitor I nNOS Inhibitor I is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. nNOS Inhibitor I  Chemical Structure
  19. GC14210 NSC 405020 N/A NSC 405020  Chemical Structure
  20. GC15005 ONO 4817 An inhibitor of MMP-2 and MMP-9 ONO 4817  Chemical Structure
  21. GC63132 Otaplimastat Otaplimastat (SP-8203), a matrix metalloproteinase (MMP) inhibitor, blocks N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in a competitive manner. Otaplimastat  Chemical Structure
  22. GC47847 Oxamyl A carbamate pesticide Oxamyl  Chemical Structure
  23. GC12111 PD 166793 An broad-spectrum MMP inhibitor PD 166793  Chemical Structure
  24. GC38831 PF-00356231 hydrochloride PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride  Chemical Structure
  25. GC41251 Pirlindole Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively). Pirlindole  Chemical Structure
  26. GC33164 PNU-248686A PNU-248686A is a novel matrix metalloproteinase (MMP) inhibitor. PNU-248686A  Chemical Structure
  27. GN10578 Polygalacic acid Polygalacic acid  Chemical Structure
  28. GC47965 Pomalidomide-d5 An internal standard for the quantification of pomalidomide Pomalidomide-d5  Chemical Structure
  29. GC40220 Pravastatin-d3 (sodium salt) Pravastatin-d3 is intended for use as an internal standard for the quantification of pravastatin by GC- or LC-MS. Pravastatin-d3 (sodium salt)  Chemical Structure
  30. GC32951 Prinomastat (AG3340) Prinomastat (AG3340) (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat (AG3340) inhibits MMP-2, MMP-3 and MMP-9 with Kis of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat (AG3340) crosses blood-brain barrier. Antitumor avtivity. Prinomastat (AG3340)  Chemical Structure
  31. GC38837 Prinomastat hydrochloride An inhibitor of MMP-2, -3, -9, -13, and -14 Prinomastat hydrochloride  Chemical Structure
  32. GC18791 Prostaglandin H1 Prostaglandin H1 (PGH1) is a COX metabolite of DGLA and is the precursor to all 1-series PGs and thromboxanes. Prostaglandin H1  Chemical Structure
  33. GC40234 Ramipril-d5 Ramipril-d5 is intended for use as an internal standard for the quantification of ramipril by GC- or LC-MS. Ramipril-d5  Chemical Structure
  34. GC18659 Ribavirin 5'-monophosphate (lithium salt) Ribavirin 5'-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis. Ribavirin 5'-monophosphate (lithium salt)  Chemical Structure
  35. GC40221 Ritonavir-d6 Ritonavir-d6 is intended for use as an internal standard for the quantification of ritonavir by GC- or LC-MS. Ritonavir-d6  Chemical Structure
  36. GC33881 Ro 31-9790 (GI4747) Ro 31-9790 (GI4747) is a synthetic metalloproteinase (MMP) inhibitor. Ro 31-9790 (GI4747)  Chemical Structure
  37. GC48060 Rosuvastatin-d6 (sodium salt) An internal standard for the quantification of rosuvastatin Rosuvastatin-d6 (sodium salt)  Chemical Structure
  38. GC32938 S 3304 S 3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9. S 3304  Chemical Structure
  39. GC31734 S-methyl-KE-298 (M-2) S-methyl-KE-298 (M-2) is an active metabolite of KE-298. S-methyl-KE-298 (M-2)  Chemical Structure
  40. GN10211 Salvianolic acid A Salvianolic acid A  Chemical Structure
  41. GC16577 SB-3CT gelatinases inhibitor, potent and selective SB-3CT  Chemical Structure
  42. GC46220 SD 2590 (hydrochloride) An MMP inhibitor SD 2590 (hydrochloride)  Chemical Structure
  43. GC18510 Siccanin Siccanin is an inhibitor of mitochondrial complex II (succinate dehydrogenase; IC50s = 0.87 and 9.3 μM for P. Siccanin  Chemical Structure
  44. GC44891 Simeprevir (sodium salt) Simeprevir (TMC435; TMC435350) sodium is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir (sodium salt)  Chemical Structure
  45. GC48093 Spiromesifen An insecticide and acaricide Spiromesifen  Chemical Structure
  46. GC41258 Spiroxamine Spiroxamine is a tertiary amine fungicide and an inhibitor of δ14 reductase/δ8→δ7 isomerase. Spiroxamine  Chemical Structure
  47. GC18706 SR 9186 A selective inhibitor of CYP3A4 SR 9186  Chemical Structure
  48. GN10359 Stigmasterol

    Stigmasterol is a naturally available sterol. stigmasterol has significant anti-arthritis and anti-inflammatory effects.

    Stigmasterol  Chemical Structure
  49. GC50353 T 26c disodium salt Highly potent and selective MMP13 inhibitor T 26c disodium salt  Chemical Structure
  50. GC31862 T-26c A selective inhibitor of MMP-13 T-26c  Chemical Structure
  51. GC16165 T-5224

    T-5224 is a non-peptidic small molecule AP-1 inhibitor

    T-5224  Chemical Structure
  52. GC44990 Tanomastat Tanomastat is an orally available, non-peptidic inhibitor of matrix metalloproteinase-2 (MMP-2), MMP-3, and MMP-9 (Kis = 11, 143, and 301 nM, respectively). Tanomastat  Chemical Structure
  53. GC50189 TAPI 0 ADAM-17 (TACE) and MMP inhibitor TAPI 0  Chemical Structure
  54. GC12344 TAPI-1 TACE/ADAM17 inhibitor TAPI-1  Chemical Structure
  55. GC19347 TAPI-2 TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 uM for MMP. TAPI-2  Chemical Structure
  56. GC46026 TMI 1 An ADAM and MMP inhibitor TMI 1  Chemical Structure
  57. GC45086 Trigalacturonic Acid

    Trigalacturonic acid is an oligosaccharide that inhibits proteinase activity in tomato plants (ED50 = 2.6 μg/plant).

    Trigalacturonic Acid  Chemical Structure
  58. GC67947 Triolein 13C3 Triolein 13C3  Chemical Structure
  59. GC45090 Triparanol Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 μM), which is an enzyme involved in the biosynthesis of cholesterol. Triparanol  Chemical Structure
  60. GC38530 UK 356618 An inhibitor of MMP-3 UK 356618  Chemical Structure
  61. GC16579 UK 370106 UK 370106  Chemical Structure
  62. GC13707 WAY 170523 WAY 170523  Chemical Structure
  63. GC32505 XL-784 XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively. XL-784  Chemical Structure
  64. GC38871 XL-784 free base XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13, respectively. XL-784 free base  Chemical Structure
  65. GC64992 YH-306 YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization. YH-306  Chemical Structure
  66. GC45177 Z-AEVD-FMK

    Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.

    Z-AEVD-FMK  Chemical Structure

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