MMP
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.
Products for MMP
- Cat.No. Product Name Information
- GC40624 MMP-3 Inhibitor VIII Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.
- GC18616 MMP-8 Inhibitor I MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM.
- GC44237 MMP-9 Inhibitor I MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively).
- GC38929 MMP-9-IN-1 MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, whichselectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs.
- GC18612 MMP-9/MMP-13 Inhibitor I MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both).
- GC65957 MMP13-IN-2 MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 (IC50=0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1, 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease research.
- GC63322 MMP13-IN-3 MMP13-IN-3 is a potent, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis.
- GC36635 MMP3 inhibitor 1 MMP3 inhibitor 1 is a potent and highly selective MMP-3 inhibitor with an IC50 of 1 nM.
- GN10360 Morroniside
- GC19483 MS-PPOH Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway.
- GC47712 Mycophenolate Mofetil-d4 An internal standard for the quantification of mycophenolate mofetil
- GC44306 N-acetyl-S-geranylgeranyl-L-Cysteine N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase).
- GC44441 N-Oleoyl Leucine N-Oleoyl leucine is an N-acyl amide generated by PM20D1 that uncouples mitochondrial respiration independent of uncoupling protein 1 (UCP1) in vitro.
- GC44341 ND-336 ND-336 is a selective inhibitor of the gelatinases matrix metalloproteinase-2 (MMP-2) and MMP-9, as well as MMP-14 (Kis = 85, 150, and 120 nM, respectively).
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GC69554
NFF-3 TFA
NFF-3 TFA peptide is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 and is hydrolyzed by them. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. By labeling NFF-3 TFA with CyDye Cy3/Cy5Q, fluorescence can be generated in cell experiments to detect cellular activity.
- GC15726 NNGH cell-permeable, broad-spectrum inhibitor of MMPs
- GC44431 nNOS Inhibitor I nNOS Inhibitor I is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM.
- GC14210 NSC 405020 N/A
- GC15005 ONO 4817 An inhibitor of MMP-2 and MMP-9
- GC63132 Otaplimastat Otaplimastat (SP-8203), a matrix metalloproteinase (MMP) inhibitor, blocks N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in a competitive manner.
- GC47847 Oxamyl A carbamate pesticide
- GC12111 PD 166793 An broad-spectrum MMP inhibitor
- GC38831 PF-00356231 hydrochloride PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM).
- GC41251 Pirlindole Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively).
- GC33164 PNU-248686A PNU-248686A is a novel matrix metalloproteinase (MMP) inhibitor.
- GN10578 Polygalacic acid
- GC47965 Pomalidomide-d5 An internal standard for the quantification of pomalidomide
- GC40220 Pravastatin-d3 (sodium salt) Pravastatin-d3 is intended for use as an internal standard for the quantification of pravastatin by GC- or LC-MS.
- GC32951 Prinomastat (AG3340) Prinomastat (AG3340) (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat (AG3340) inhibits MMP-2, MMP-3 and MMP-9 with Kis of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat (AG3340) crosses blood-brain barrier. Antitumor avtivity.
- GC38837 Prinomastat hydrochloride An inhibitor of MMP-2, -3, -9, -13, and -14
- GC18791 Prostaglandin H1 Prostaglandin H1 (PGH1) is a COX metabolite of DGLA and is the precursor to all 1-series PGs and thromboxanes.
- GC40234 Ramipril-d5 Ramipril-d5 is intended for use as an internal standard for the quantification of ramipril by GC- or LC-MS.
- GC18659 Ribavirin 5'-monophosphate (lithium salt) Ribavirin 5'-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis.
- GC40221 Ritonavir-d6 Ritonavir-d6 is intended for use as an internal standard for the quantification of ritonavir by GC- or LC-MS.
- GC33881 Ro 31-9790 (GI4747) Ro 31-9790 (GI4747) is a synthetic metalloproteinase (MMP) inhibitor.
- GC48060 Rosuvastatin-d6 (sodium salt) An internal standard for the quantification of rosuvastatin
- GC32938 S 3304 S 3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.
- GC31734 S-methyl-KE-298 (M-2) S-methyl-KE-298 (M-2) is an active metabolite of KE-298.
- GN10211 Salvianolic acid A
- GC16577 SB-3CT gelatinases inhibitor, potent and selective
- GC46220 SD 2590 (hydrochloride) An MMP inhibitor
- GC18510 Siccanin Siccanin is an inhibitor of mitochondrial complex II (succinate dehydrogenase; IC50s = 0.87 and 9.3 μM for P.
- GC44891 Simeprevir (sodium salt) Simeprevir (TMC435; TMC435350) sodium is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM.
- GC48093 Spiromesifen An insecticide and acaricide
- GC41258 Spiroxamine Spiroxamine is a tertiary amine fungicide and an inhibitor of δ14 reductase/δ8→δ7 isomerase.
- GC18706 SR 9186 A selective inhibitor of CYP3A4
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GN10359
Stigmasterol
Stigmasterol is a naturally available sterol. stigmasterol has significant anti-arthritis and anti-inflammatory effects.
- GC50353 T 26c disodium salt Highly potent and selective MMP13 inhibitor
- GC31862 T-26c A selective inhibitor of MMP-13
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GC16165
T-5224
T-5224 is a non-peptidic small molecule AP-1 inhibitor
- GC44990 Tanomastat Tanomastat is an orally available, non-peptidic inhibitor of matrix metalloproteinase-2 (MMP-2), MMP-3, and MMP-9 (Kis = 11, 143, and 301 nM, respectively).
- GC50189 TAPI 0 ADAM-17 (TACE) and MMP inhibitor
- GC12344 TAPI-1 TACE/ADAM17 inhibitor
- GC19347 TAPI-2 TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 uM for MMP.
- GC46026 TMI 1 An ADAM and MMP inhibitor
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GC45086
Trigalacturonic Acid
Trigalacturonic acid is an oligosaccharide that inhibits proteinase activity in tomato plants (ED50 = 2.6 μg/plant).
- GC67947 Triolein 13C3
- GC45090 Triparanol Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 μM), which is an enzyme involved in the biosynthesis of cholesterol.
- GC38530 UK 356618 An inhibitor of MMP-3
- GC16579 UK 370106
- GC13707 WAY 170523
- GC32505 XL-784 XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively.
- GC38871 XL-784 free base XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13, respectively.
- GC64992 YH-306 YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization.
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GC45177
Z-AEVD-FMK
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.