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Neprilysin

Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.

Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.

Targets for  Neprilysin

Products for  Neprilysin

  1. Cat.No. Product Name Information
  2. GC16138 AHU-377 hemicalcium salt AHU-377 hemicalcium salt (AHU-377 hemicalcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 hemicalcium salt  Chemical Structure
  3. GC10146 AHU-377(Sacubitril) AHU-377(Sacubitril) (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC50 of 5 nM. AHU-377(Sacubitril)  Chemical Structure
  4. GC31608 Candoxatril (UK 79300) Candoxatril (UK 79300) is a neutral endopeptidase (NEP) inhibitor. Candoxatril (UK 79300)  Chemical Structure
  5. GC11784 LCZ696 LCZ696 (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure. LCZ696  Chemical Structure
  6. GC31267 NEP-In-1 NEP-IN-1 is a neutral endopeptidase (NEP) inhibitor with IC50 of 2 nM for dNEP. NEP-In-1  Chemical Structure
  7. GC32671 NEP-IN-2 NEP-IN-2 is an inhibitor of neutral endopeptidase, used in the research of proliferation in atherosclerosis, restenosis. NEP-IN-2  Chemical Structure
  8. GC16768 Phosphoramidon Disodium Salt Phosphoramidon Disodium Salt is a metalloprotease inhibitor. Phosphoramidon Disodium Salt  Chemical Structure
  9. GC17017 Racecadotril Potent enkephalinase inhibitor Racecadotril  Chemical Structure
  10. GC63732 Sacubitril-13C4 hemicalcium salt Sacubitril-13C4 hemicalcium salt  Chemical Structure
  11. GC30786 Sacubitrilat (LBQ-657) Sacubitrilat (LBQ-657) (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor. Sacubitrilat (LBQ-657)  Chemical Structure
  12. GC31583 SQ28603 (SQ28,603) SQ28603 (SQ28,603) is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP). SQ28603 (SQ28,603)  Chemical Structure
  13. GC38856 TD-0212 TFA TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP. TD-0212 TFA  Chemical Structure

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