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Home >> Signaling Pathways >> Proteases >> Thrombin

Thrombin

Thrombin is a Na+ -activated allosteric serine protease that catalyzes the formation of thrombus as well as a series of flux-regulating reactions through the coagulation cascade. In response to vascular injury, thrombin is produced through the activation of its inactive precursor, prothrobin, catalyzed by Factor Xa (a trypsin-like proteinase). As a serine protease characterized by the presence of a catalytic triad, thrombin possess a triad of S195-H57-D189 in its active center, which is required for the nucleophilic attack of the target peptide bond. Located “south-west” of the active center is a Na+ -binding site, through which the binding of a sodium ion allosterically modulates the activity of the serine proteinase.

Products for  Thrombin

  1. Cat.No. Product Name Information
  2. GC11101 5-R-Rivaroxaban 5-R-Rivaroxaban Chemical Structure
  3. GC14502 AEBSF.HCl

    AEBSF.HCl is a broad-spectrum irreversible inhibitor of serine proteases, which can inhibit chymotrypsin, kallikrein, plasmin, thrombin, trypsin and related thrombolytic enzymes.

     AEBSF.HCl Chemical Structure
  4. GC13130 Apixaban An inhibitor of Factor Xa Apixaban Chemical Structure
  5. GC11672 Argatroban Thrombin mediated fibrinogen cleavage inhibitor Argatroban Chemical Structure
  6. GC35384 Argatroban monohydrate Argatroban (monohydrate) (MD-805 (monohydrate)) is a direct, selective thrombin inhibitor. Argatroban monohydrate Chemical Structure
  7. GC16293 BIBR 953 (Dabigatran, Pradaxa) A thrombin inhibitor BIBR 953 (Dabigatran, Pradaxa) Chemical Structure
  8. GC15180 BIBR-1048 BIBR-1048 (BIBR 1048) is an orally active prodrug of Dabigatran (a direct inhibitor of thrombin). BIBR-1048 Chemical Structure
  9. GC35528 Bivalirudin TFA Bivalirudin TFA is a synthetic 20 residue peptide which reversibly inhibits thrombin. Bivalirudin TFA Chemical Structure
  10. GC10448 Bivalirudin Trifluoroacetate A thrombin inhibitor Bivalirudin Trifluoroacetate Chemical Structure
  11. GC61787 Dabigatran D4 hydrochloride Dabigatran D4 hydrochloride Chemical Structure
  12. GC34373 Dabigatran D4 hydrochloride (BIBR-953 D4 hydrochloride) Dabigatran D4 hydrochloride (BIBR-953 D4 hydrochloride) Chemical Structure
  13. GC15390 Dabigatran etexilate mesylate A prodrug form of dabigatran Dabigatran etexilate mesylate Chemical Structure
  14. GC12875 Dabigatran ethyl ester Dabigatran ethyl ester Chemical Structure
  15. GC35802 Dabigatran ethyl ester hydrochloride Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and a thrombin inhibitor. Dabigatran ethyl ester hydrochloride Chemical Structure
  16. GC32663 Desethyl KBT-3022 Desethyl KBT-3022 is the main active metabolite of the new antiplatelet agent, KBT-3022. Desethyl KBT-3022 Chemical Structure
  17. GC11644 Edoxaban Edoxaban Chemical Structure
  18. GC62298 Edoxaban impurity 4 Edoxaban impurity 4 is an impurity of Edoxaban. Edoxaban impurity 4 Chemical Structure
  19. GC62439 Edoxaban impurity 6 Edoxaban impurity 6 Chemical Structure
  20. GC12839 Edoxaban tosylate monohydrate A potent inhibitor of Factor Xa Edoxaban tosylate monohydrate Chemical Structure
  21. GC10398 Heparin sodium

    Heparin sodium, as as anti-coagulants, belongs to a class of glucans, which can interact with a variety of proteins to produce a variety of biological activities.

     Heparin sodium Chemical Structure
  22. GC19766 Heparin sodium salt (MW 15kDa)

    A polymer of Heparin with the molecular weight of 15kD

     Heparin sodium salt (MW 15kDa) Chemical Structure
  23. GC32554 Inogatran (H-314-27) Inogatran (H-314-27) (H-314-27) is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of arterial and venous thrombotic diseases. Inogatran (H-314-27) Chemical Structure
  24. GC60240 Melagatran Melagatran is a direct and orally active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran Chemical Structure
  25. GC17362 Metolazone thiazide-like diuretic Metolazone Chemical Structure
  26. GC34032 Napsagatran hydrate (Ro 46-6240 hydrate) Napsagatran hydrate (Ro 46-6240 hydrate) is a novel and specific thrombin inhibitor. Napsagatran hydrate (Ro 46-6240 hydrate) Chemical Structure
  27. GC18249 NQ301 A naphthoquinone with diverse biological activities NQ301 Chemical Structure
  28. GC36792 Odiparcil Odiparcil (SB-424323) is an orally active beta-d-thioxyloside analog with antithrombotic activity associated with a reduced risk of adverse bleeding events. Odiparcil Chemical Structure
  29. GC32619 OM-189 OM-189 is a selective synthetic thrombin inhibitor. OM-189 Chemical Structure
  30. GC17726 Otamixaban Otamixaban Chemical Structure
  31. GC10277 PPACK Dihydrochloride

    PPACK is a potent selective and irreversible thrombin inhibitor that inhibits human alpha thrombin with a Ki value of 0.24 nM. PPACK inhibit the binding of rt-PA to plasma protease inhibitors in vitro.

     PPACK Dihydrochloride Chemical Structure
  32. GC32567 RWJ-445167 (3DP-10017) RWJ-445167 (3DP-10017) (3DP-10017) is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity. RWJ-445167 (3DP-10017) Chemical Structure
  33. GC61495 Thrombin (MW 37kDa)

    Thrombin (MW 37kDa) is a Na+-activated, allosteric serine protease. Thrombin induces the activation of ERK1 and ERK2

     Thrombin (MW 37kDa) Chemical Structure
  34. GC32639 Thrombin inhibitor 1 Thrombin inhibitor 1 is a potent thrombin inhibitor (Ki=0.66 nM, 2xaPTT=0.43 μM). Thrombin inhibitor 1 Chemical Structure
  35. GC37785 Thrombin Inhibitor 2 Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor, extracted from US8541580B2. Thrombin Inhibitor 2 Chemical Structure
  36. GC10140 Thrombin Receptor Agonist Peptide Thrombin Receptor Agonist Peptide is a synthetic thrombin receptor agonist peptide. Thrombin Receptor Agonist Peptide Chemical Structure
  37. GC34255 TP508 TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 Chemical Structure
  38. GC39515 TP508 TFA TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA Chemical Structure
  39. GC17423 TS 155-2 macrocyclic lactone that inhibits thrombin-stimulated calcium entry into cells TS 155-2 Chemical Structure
  40. GC38332 Ximelagatran A prodrug of melagatran, a thrombin inhibitor Ximelagatran Chemical Structure

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