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Home >> Signaling Pathways >> Stem Cell

Stem Cell

Products for  Stem Cell

  1. Cat.No. Product Name Information
  2. GC36073 Foxy-5 Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. Foxy-5 Chemical Structure
  3. GC64005 FPFT-2216 FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 Chemical Structure
  4. GC17457 FRATide GSK-3 inhibitor FRATide Chemical Structure
  5. GC41534 FzM1 Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. FzM1 Chemical Structure
  6. GC50624 FzM1.8 Frizzled 4 allosteric agonist; exhibits biased siginaling; preserves stemness FzM1.8 Chemical Structure
  7. GC18595 G244-LM An inhibitor of Wnt signaling G244-LM Chemical Structure
  8. GC65116 GA-017 GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids. GA-017 Chemical Structure
  9. GC43725 Gallocyanine Gallocyanine, a synthetic blue dyestuff, blocks DKK1 inhibitory activity by disrupting DKK1/LRP6 interaction. Gallocyanine Chemical Structure
  10. GC43729 Ganglioside GD3 Mixture (sodium salt) Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. Ganglioside GD3 Mixture (sodium salt) Chemical Structure
  11. GC43734 Ganglioside GQ1b Mixture (sodium salt) Ganglioside GQ1b is a tetrasialoganglioside that contains two sialic acid residues linked to an inner galactose unit. Ganglioside GQ1b Mixture (sodium salt) Chemical Structure
  12. GC16789 GANT 58 An inhibitor of Gli transcription GANT 58 Chemical Structure
  13. GC10359 GANT61

    GANT61 was able to efficiently block GLI1 as well as GLI2-induced transcription, IC50 is 5 µM.

     GANT61 Chemical Structure
  14. GC10493 GDC-0449 (Vismodegib) GDC-0449 (Vismodegib) Chemical Structure
  15. GC33304 Gigantol Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. Gigantol Chemical Structure
  16. GC31717 Ginkgetin A biflavonoid with diverse biological activities Ginkgetin Chemical Structure
  17. GC32877 GNF-6231 GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling. GNF-6231 Chemical Structure
  18. GC38787 GNF4877 GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66?μM for mouse β (R7T1) cells). GNF4877 Chemical Structure
  19. GC49687 Goralatide (acetate) A tetrapeptide regulator of hematopoiesis Goralatide (acetate) Chemical Structure
  20. GC14640 GSA 10 Smoothened (Smo) receptor agonist GSA 10 Chemical Structure
  21. GC36190 GSK-3 inhibitor 1 GSK-3 inhibitor 1 is an inhibitor of GSK-3. GSK-3 inhibitor 1 Chemical Structure
  22. GC14987 GSK-3 Inhibitor IX (BIO) GSK-3 Inhibitor IX (BIO) (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively. GSK-3 Inhibitor IX (BIO) Chemical Structure
  23. GC36193 GSK-3β inhibitor 1 GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM. GSK-3β inhibitor 1 Chemical Structure
  24. GC66032 GSK-3β inhibitor 11 GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research. GSK-3β inhibitor 11 Chemical Structure
  25. GC15783 GSK126

    A selective EZH2 inhibitor

     GSK126 Chemical Structure
  26. GC66035 GSK3-IN-1 GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes. GSK3-IN-1 Chemical Structure
  27. GC17534 GSK343 A selective, cell-permeable EZH2 inhibitor GSK343 Chemical Structure
  28. GC18875 GSK3β Inhibitor XVIII An inhibitor of GSK3β GSK3β Inhibitor XVIII Chemical Structure
  29. GC11414 GSK503 EZH2 inhibitor GSK503 Chemical Structure
  30. GC14896 Halcinonide Anti-inflammatory agent Halcinonide Chemical Structure
  31. GC43809 Hedgehog Antagonist VIII Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. Hedgehog Antagonist VIII Chemical Structure
  32. GC39266 Hematein Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells. Hematein Chemical Structure
  33. GC30767 Heparan Sulfate

    Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on cell surfaces and in the extracellular matrix.

     Heparan Sulfate Chemical Structure
  34. GC49027 Hexamethylene bisacetamide Hexamethylene bisacetamide is a tumor cell-differentiating agent. Hexamethylene bisacetamide Chemical Structure
  35. GC64134 Hh-Ag1.5 Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5 Chemical Structure
  36. GC12951 HhAntag A hedgehog pathway inhibitor HhAntag Chemical Structure
  37. GC16963 HLY78 positive modulator of the Wnt/β-catenin pathway HLY78 Chemical Structure
  38. GC11045 HPI 1 HPI 1 is a potent GLI antagonist with an IC50 value of 1.1 μM. HPI 1 shows anti-proliferative activity. HPI 1 decreases the GLI1 mRNA expression. HPI 1 inhibits colony formation in a dose-dependent manner. HPI 1 Chemical Structure
  39. GC47435 HPI-1 (hydrate) A Hedgehog pathway inhibitor HPI-1 (hydrate) Chemical Structure
  40. GC43873 Hydrocortisone 21-hemisuccinate (sodium salt) Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. Hydrocortisone 21-hemisuccinate (sodium salt) Chemical Structure
  41. GC61410 I3MT-3 I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM). I3MT-3 Chemical Structure
  42. GC14503 IC261 CK1 inhibitor IC261 Chemical Structure
  43. GC16893 ICG 001 An inhibitor of β-catenin/CBP interactions ICG 001 Chemical Structure
  44. GC16640 iCRT 14 CRT inhibitor iCRT 14 Chemical Structure
  45. GC19198 iCRT3 iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription. iCRT3 Chemical Structure
  46. GC15123 IDE 1 activate the TGF-β signaling pathway IDE 1 Chemical Structure
  47. GC10854 IDE 2 inducer of definitive endoderm formation IDE 2 Chemical Structure
  48. GC50203 IHR-Cy3 Potent fluorescent Smo antagonist IHR-Cy3 Chemical Structure
  49. GC16617 IM-12 GSK-3β inhibitor, potent IM-12 Chemical Structure
  50. GC12741 IMR-1 Notch pathway inhibitor IMR-1 Chemical Structure
  51. GC36304 IMR-1A IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A. IMR-1A Chemical Structure
  52. GC12661 Indirubin-3'-oxime Indirubin-3'-oxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 μM, respectively; Indirubin-3'-oxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM. Indirubin-3'-oxime Chemical Structure
  53. GC36312 Indirubin-3'-monoxime-5-sulphonic acid Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively. Indirubin-3'-monoxime-5-sulphonic acid Chemical Structure
  54. GC36313 Indirubin-5-sulfonate Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate Chemical Structure
  55. GC10910 IQ 1 IQ 1 is a Wnt/β-catenin/CBP signalling sustainer. IQ 1 Chemical Structure
  56. GC10472 ISX 9 Neurogenic agent ISX 9 Chemical Structure
  57. GC47474 Itraconazole-d5 An internal standard for the quantification of itraconazole Itraconazole-d5 Chemical Structure
  58. GC16013 IWP 4 Potent inhibitor of Wnt/β-catenin signaling IWP 4 Chemical Structure
  59. GC16454 IWP-2 IWP-2 is a inhibitor of the Wnt signaling pathway, with an IC50 value of 27 nM. IWP-2 is also an ATP-competitive inhibitor of CK1δ, with an IC50 value of 40 nM. IWP-2 Chemical Structure
  60. GC14546 IWP-2-V2 Wnt production inhibitor IWP-2-V2 Chemical Structure
  61. GC17071 IWP-3 inhibitor of Wnt production IWP-3 Chemical Structure
  62. GC17708 IWP-L6 Porcupine inhibitor,highy potent IWP-L6 Chemical Structure
  63. GC34628 IWP-O1 IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 Chemical Structure
  64. GC10950 IWR-1-endo IWR-1-endo is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. IWR-1-endo Chemical Structure
  65. GC36361 Jagged-1 (188-204) TFA A fragment of the Jagged-1 (JAG-1) protein Jagged-1 (188-204) TFA Chemical Structure
  66. GC36362 Jagged-1 188-204 Jagged-1 188-204 is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells. Jagged-1 188-204 Chemical Structure
  67. GC11111 Jervine Hedgehog signaling Inhibitor Jervine Chemical Structure
  68. GC34635 JI051 JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity. JI051 Chemical Structure
  69. GC15256 JK 184 Hh signaling inhibitor JK 184 Chemical Structure
  70. GC18734 JS-K JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH. JS-K Chemical Structure
  71. GC12869 JW 55 A TNKS1/2 inhibitor JW 55 Chemical Structure
  72. GC10138 JW 67 inhibitor of canonical Wnt pathway signaling JW 67 Chemical Structure
  73. GC13978 JW 74 inhibitor of the catalytic PARP domain of TNKS1/2 JW 74 Chemical Structure
  74. GC62132 K-975 K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma. K-975 Chemical Structure
  75. GC15057 Kartogenin Promote differentiation of multipotent MSCs into chondrocytes Kartogenin Chemical Structure
  76. GC14182 Kenpaullone CDK1/cyclin B and GSK-3β inhibitor Kenpaullone Chemical Structure
  77. GC13582 KHS 101 hydrochloride neuronal differentiation inducer KHS 101 hydrochloride Chemical Structure
  78. GC14572 KY 02111 Induces stem cell differentiation KY 02111 Chemical Structure
  79. GC46015 KY 05009 A TNIK inhibitor KY 05009 Chemical Structure
  80. GC63465 KY-02327 KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 Chemical Structure
  81. GC65356 KY-02327 acetate KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate Chemical Structure
  82. GC32923 KY1220 KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells. KY1220 Chemical Structure
  83. GC19216 KYA1797K A potent and selective Wnt/β-catenin inhibitor KYA1797K Chemical Structure
  84. GC47538 L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) Chemical Structure
  85. GC36483 L-Quebrachitol L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway. L-Quebrachitol Chemical Structure
  86. GC10573 L803-mts Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3) L803-mts Chemical Structure
  87. GC61527 Lats-IN-1 Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 Chemical Structure
  88. GC13655 LDE225 (NVP-LDE225,Erismodegib) LDE225 (NVP-LDE225,Erismodegib) (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively. LDE225 (NVP-LDE225,Erismodegib) Chemical Structure
  89. GC14169 LDE225 Diphosphate A Smo antagonist LDE225 Diphosphate Chemical Structure
  90. GC32954 LEQ506 (NVP-LEQ506) LEQ506 (NVP-LEQ506) is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. LEQ506 (NVP-LEQ506) Chemical Structure
  91. GC32763 LF3 LF3 is an antagonist of the β-Catenin/TCF4 interaction with antitumor activity; has an IC50 of 1.65 μM. LF3 Chemical Structure
  92. GC12392 LGK-974 PORCN inhibitor,potent and specific LGK-974 Chemical Structure
  93. GC17466 LH846 Casein kinases inhibitor LH846 Chemical Structure
  94. GC47570 Lipoxygenin An inhibitor of 5-LO Lipoxygenin Chemical Structure
  95. GC44080 LLP-3 Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 Chemical Structure
  96. GC34650 Longdaysin

    Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC50s of? 5.6 ?M, 8.8 ?M, 29 ?M, and 52 ?M, respectively.

     Longdaysin Chemical Structure
  97. GC12191 LY-411575 A γ-secretase inhibitor LY-411575 Chemical Structure
  98. GC15683 LY2940680 LY2940680 (LY2940680) is an antagonist of the smoothened receptor. LY2940680 Chemical Structure
  99. GC12653 LY3039478 A Notch inhibitor LY3039478 Chemical Structure
  100. GC13041 M 25 Smoothened (Smo) receptor antagonist M 25 Chemical Structure
  101. GC25603 M2912 M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity. M2912 Chemical Structure

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