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Stem Cell

Products for  Stem Cell

  1. Cat.No. Product Name Information
  2. GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram Methyl Diethyldithiocarbamate  Chemical Structure
  3. GC31794 Methyl vanillate

    Methyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator.

    Methyl vanillate  Chemical Structure
  4. GC13630 MK-4101 Hedgehog (Hh) signaling pathway inhibitor MK-4101  Chemical Structure
  5. GC17468 ML 239 inhibitor of the breast cancer stem cells ML 239  Chemical Structure
  6. GC17339 ML-243 inhibitor of cancer stem cells ML-243  Chemical Structure
  7. GC44213 ML115 Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115  Chemical Structure
  8. GC18616 MMP-8 Inhibitor I MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. MMP-8 Inhibitor I  Chemical Structure
  9. GC44245 MoTP MoTP, known more formally as 4-(4-morpholinobutylthio)phenol, is used to ablate larval melanocytes in zebrafish in order to study melanocyte regeneration. MoTP  Chemical Structure
  10. GC12192 MRT 10 MRT 10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT 10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT 10 can be used for the research of cancer. MRT 10  Chemical Structure
  11. GC64419 MRT-14 MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling. MRT-14  Chemical Structure
  12. GC63336 MRT-81 MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer. MRT-81  Chemical Structure
  13. GC33114 MRT-83 MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling. MRT-83  Chemical Structure
  14. GC63863 MRT-83 hydrochloride MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease. MRT-83 hydrochloride  Chemical Structure
  15. GC44250 MS351

    MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain.

    MS351  Chemical Structure
  16. GC65993 MSC-4106 MSC-4106 is an orally active and potent inhibitor of YAP/TAZ-TEAD. MSC-4106 inhibits TEAD1 or TEAD3 auto-palmitoylation and shows inhibitory effect on NCI-H226 tumor xenograft model. MSC-4106  Chemical Structure
  17. GC63088 MYF-01-37 MYF-01-37 is a covalent TEAD inhibitor targeting Cys380. MYF-01-37 has a reversible inhibition on YAP/TEAD interaction. MYF-01-37  Chemical Structure
  18. GC63100 N-Desmethylnefopam D5 hydrochloride N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride. N-Desmethylnefopam D5 hydrochloride  Chemical Structure
  19. GC44458 N-Palmitoyl-L-Aspartate N-Palmitoyl-L-aspartate is a natural N-acylaspartate that inhibits Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. N-Palmitoyl-L-Aspartate  Chemical Structure
  20. GC44321 Nat-20(S)-yne Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. Nat-20(S)-yne  Chemical Structure
  21. GC19260 NCB-0846 NCB-0846 is an orally available TNIK inhibitor with an IC50 of 21 nM. NCB-0846  Chemical Structure
  22. GC36708 NCC007 NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007  Chemical Structure
  23. GC64837 Nefopam D3 hydrochloride Nefopam D3 hydrochloride  Chemical Structure
  24. GC11775 Nefopam HCl Nefopam HCl (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam HCl  Chemical Structure
  25. GC38522 Neurodazine Small molecule inducer of neuronal differentiation Neurodazine  Chemical Structure
  26. GC11454 Neurodazine Induces neurogenesis of non-pluripotent C2C12 myoblasts Neurodazine  Chemical Structure
  27. GC50489 NLS-StAx-h Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions NLS-StAx-h  Chemical Structure
  28. GC67737 NLS-StAx-h TFA NLS-StAx-h TFA  Chemical Structure
  29. GC64536 Notch 1 TFA Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Notch 1 TFA  Chemical Structure
  30. GC65916 NRX-103095 NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM. NRX-103095  Chemical Structure
  31. GC65919 NRX-252114 NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation. NRX-252114  Chemical Structure
  32. GC65336 NRX-252262 NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM. NRX-252262  Chemical Structure
  33. GC64832 NRX-2663 NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 ?M and a Kd of 54.8 nM. NRX-2663  Chemical Structure
  34. GC44467 NSC 668036 NSC 668036 is an inhibitor of the Dishevelled (Dvl) protein PDZ domain (Kd = 240 μM for mouse Dvl1 PDZ domain). NSC 668036  Chemical Structure
  35. GC12499 O4I1

    potent Oct3/4 inducer

    O4I1  Chemical Structure
  36. GC17042 O4I2 Oct3/4 inducer O4I2  Chemical Structure
  37. GC10151 OAC1 Oct4 activator OAC1  Chemical Structure
  38. GC17327 OAC2 Oct4 activator OAC2  Chemical Structure
  39. GC61861 Oct3/4-inducer-1 Oct3/4-inducer-1 (compound 2) is a potent Oct3/4 inducer. Oct3/4-inducer-1  Chemical Structure
  40. GC69633 Orobol

    Orobol is a major soy isoflavone with various pharmacological activities, including anti-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K subtypes (for PI3K α/β/γ/K/δ, IC50=3.46-5.27 μM).

    Orobol  Chemical Structure
  41. GC17713 Oxy-16 Oxy-16 is an endogenous metabolic intermediate. Oxy-16  Chemical Structure
  42. GC11115 Pamidronate Pamidronate is a drug used to treat a broad spectrum of bone absorption diseases. Pamidronate  Chemical Structure
  43. GC49667 PD 168568 (hydrochloride) A dopamine D4 receptor antagonist PD 168568 (hydrochloride)  Chemical Structure
  44. GC16230 PF-04449913 PF-04449913 (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. PF-04449913 (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM. PF-04449913  Chemical Structure
  45. GC18599 PF-05274857 (hydrochloride) PF-05274857 (hydrochloride) is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-05274857 (hydrochloride) has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway. PF-05274857 (hydrochloride)  Chemical Structure
  46. GC44612 PF-4800567 PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ. PF-4800567  Chemical Structure
  47. GC36885 PF-5006739 PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739  Chemical Structure
  48. GC13280 PF-5274857 Smo antagonist,potent and selective PF-5274857  Chemical Structure
  49. GC10556 PF-670462 An inhibitor of the CK1 isoforms CK1ε and CK1δ PF-670462  Chemical Structure
  50. GC65375 Phospho-Glycogen Synthase Peptide-2(substrate) TFA Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases. Phospho-Glycogen Synthase Peptide-2(substrate) TFA  Chemical Structure
  51. GC38578 PI-828 A PI3K inhibitor PI-828  Chemical Structure
  52. GC18291 PKF118-310 PKF118-310 (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity. PKF118-310  Chemical Structure
  53. GC17107 PluriSIn #1 (NSC 14613) A selective inhibitor of stearoyl-CoA desaturase PluriSIn #1 (NSC 14613)  Chemical Structure
  54. GC16711 PNU 74654 Wnt signaling pathway inhibitor PNU 74654  Chemical Structure
  55. GC19299 Porcupine-IN-1 Porcupine-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM. Porcupine-IN-1  Chemical Structure
  56. GC65066 Prodigiosin hydrochloride Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride  Chemical Structure
  57. GC14847 Psoralidin apoptosis inducer Psoralidin  Chemical Structure
  58. GC15064 Purmorphamine Purmorphamine is the first small molecule agonist developed for Smoothened protein. Purmorphamine  Chemical Structure
  59. GC62424 PY-60 PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 ?M. PY-60  Chemical Structure
  60. GC17607 Pyrintegrin enhances the survival of hESC Pyrintegrin  Chemical Structure
  61. GC32698 Pyrvinium pamoate (Pyrvinium embonate) Pyrvinium pamoate (Pyrvinium embonate) is an FDA-approved antihelmintic drug that inhibits WNT pathway signaling. Pyrvinium pamoate (Pyrvinium embonate)  Chemical Structure
  62. GC17251 QS 11 ARFGAP1 inhibitor,Wnt/beta-catenin pathway modulator QS 11  Chemical Structure
  63. GC69802 RA-V

    RA-V is a cyclic hexapeptide. RA-V has activity against Wnt, Myc and Notch with IC50 values of 50, 75 and 93 ng/mL respectively. RA-V can be used for research on cancer-related signaling pathways.

    RA-V  Chemical Structure
  64. GC61233 RBPJ Inhibitor-1 RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation. RBPJ Inhibitor-1  Chemical Structure
  65. GC25838 RBPJ Inhibitor-1 (RIN1) RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ. RBPJ Inhibitor-1 (RIN1)  Chemical Structure
  66. GC41468 Retreversine Terminal differentiation of embryonic progenitor cells to form distinct, adult tissues is the hallmark of organogenesis in complex organisms. Retreversine  Chemical Structure
  67. GC37522 RGB-286638 A multi-kinase inhibitor RGB-286638  Chemical Structure
  68. GC37523 RGB-286638 free base A multi-kinase inhibitor RGB-286638 free base  Chemical Structure
  69. GC16197 RO4929097

    An inhibitor of γ-secretase

    RO4929097  Chemical Structure
  70. GC18475 Robotnikinin Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper embryonic development. Robotnikinin  Chemical Structure
  71. GC44851 Rosiglitazone (potassium salt) Rosiglitazone (BRL 49653) potassium is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone (potassium salt)  Chemical Structure
  72. GC64922 Rovalpituzumab Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine. Rovalpituzumab has activity against small cell lung cancer (SCLC). Rovalpituzumab  Chemical Structure
  73. GC11987 RSC-133 promotes the reprogramming of human somatic cells to pluripotent stem cells RSC-133  Chemical Structure
  74. GC37573 RU-SKI 43 RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity. RU-SKI 43  Chemical Structure
  75. GC44855 RU-SKI 43 (hydrochloride) An inhibitor of hedgehog acyltransferase RU-SKI 43 (hydrochloride)  Chemical Structure
  76. GC12068 SAG Hh and Smo agonist SAG  Chemical Structure
  77. GC50135 SAG 21k Hedgehog signaling activator; brain penetrant and orally bioavailable SAG 21k  Chemical Structure
  78. GC37580 SAG hydrochloride SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo. SAG hydrochloride  Chemical Structure
  79. GC62258 SAG-d3 SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG-d3  Chemical Structure
  80. GC50470 SAHM1 Notch pathway inhibitor; prevents Notch complex assembly SAHM1  Chemical Structure
  81. GC14882 Salinomycin A selective cancer stem cell inhibitor Salinomycin  Chemical Structure
  82. GC18107 Salinomycin sodium salt A selective cancer stem cell inhibitor Salinomycin sodium salt  Chemical Structure
  83. GC15889 SANT-1 Shh inhibitor,potent and cell-permeable SANT-1  Chemical Structure
  84. GC11193 SANT-2 SANT-2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT-2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers. SANT-2  Chemical Structure
  85. GC32978 Saridegib (IPI-926) Saridegib (IPI-926) is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway. Saridegib (IPI-926)  Chemical Structure
  86. GC48070 SB-431542 (hydrate) Inhibitor of receptors ALK4, ALK5, and ALK7 SB-431542 (hydrate)  Chemical Structure
  87. GC12096 Semagacestat (LY450139) A pan γ-secretase inhibitor Semagacestat (LY450139)  Chemical Structure
  88. GC64382 SGC-CK2-1 SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC50s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1  Chemical Structure
  89. GC16320 Shz 1 induces phenotypic differentiation Shz 1  Chemical Structure
  90. GC16701 SKI II Sphingosine kinase(SK) inhibitor SKI II  Chemical Structure
  91. GC16382 SKL2001 An activator of Wnt/β-catenin signaling SKL2001  Chemical Structure
  92. GC12228 SMANT hydrochloride Smoothened (Smo) signaling inhibitor SMANT hydrochloride  Chemical Structure
  93. GC19336 SR-3029 SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases. SR-3029  Chemical Structure
  94. GC61781 Super-TDU Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model. Super-TDU  Chemical Structure
  95. GC37704 Super-TDU (1-31) TFA Super-TDU (1-31) TFA  Chemical Structure
  96. GC34818 Super-TDU 1-31 Super-TDU 1-31  Chemical Structure
  97. GC14441 SW033291 15-PGDH enzyme inhibitor SW033291  Chemical Structure
  98. GC13825 TA 01

    CK1ε, CK1δ,and p38α inhibitor

    TA 01  Chemical Structure
  99. GC11635 TA 02 p38 MAPK inhibitor TA 02  Chemical Structure
  100. GN10797 Tangeretin Tangeretin  Chemical Structure
  101. GC15041 Tankyrase Inhibitors (TNKS) 22 Tankyrase inhibitor Tankyrase Inhibitors (TNKS) 22  Chemical Structure

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