Hedgehog
Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.
Products for Hedgehog
- Cat.No. Product Name Information
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GC72838
1-Methyladenosine-d3 hydrochloride
1-Metladenosine-d3 drochloride is the drochloride salt form of deuterium labeled 1-Metladenosine.
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GC49651
19-alkyne Cholesterol
19-ethynyl Cholesterol
An alkyne derivative of cholesterol for click chemistry -
GC15422
20(S)-Hydroxycholesterol
20α-hydroxy Cholesterol
An allosteric activator of the oncoprotein smoothened (Smo) -
GC66390
3-epi-Vitamin D3
Epicholecalciferol
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells. -
GC12429
AY 9944 dihydrochloride
AY 9944 dihydrochloride is a specific cholesterol biosynthesis inhibitor.
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GC14715
AZ 12080282 dihydrochloride
Hedgehog inhibitor
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GC17153
CHIR-99021 (CT99021) HCl
CHIR-99021 monohydrochloride; CT99021 monohydrochloride
Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy. -
GC11476
Ciliobrevin A
HPI-4
Hh pathway antagonist
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GC39359
Ciliobrevin D
Ciliobrevin D is an inhibitor of dynein ATPase activity, preventing the cycling activity of the motor protein.
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GC11217
CUR 61414
G-856
potent inhibitor of hedgehog-induced cellular activity -
GC13441
Cyclopamine
11-Deoxojervine
Cyclopamine is a naturally occurring Hedgehog (Hh)-specific small-molecule signaling steroidal alkaloid inhibitor, causes a profound inhibition of tumor growth, has significant anti-invasive, anti-proliferative and anti-estrogenic potency in human breast cancer cells . -
GC43346
Cyclopamine-KAAD
Cyclopamine-KAAD, a hedgehog signaling inhibitor, is a smoothened antagonist.
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GC73776
DS-1-38
DS-1-38 is an EYA1 antagonist that blocks Sonic Hedgehog (SHH) signaling.
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GC16789
GANT 58
NSC 75503
An inhibitor of Gli transcription -
GC10359
GANT61
NSC 136476
GANT61 was able to efficiently block GLI1 as well as GLI2-induced transcription, IC50 is 5 µM. -
GC10493
GDC-0449 (Vismodegib)
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GC43809
Hedgehog Antagonist VIII
Hh Antagonist VIII
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. -
GC64134
Hh-Ag1.5
SAg1.5
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. -
GC11045
HPI 1
HPI 1 is a potent GLI antagonist with an IC50 value of 1.1 μM. HPI 1 shows anti-proliferative activity. HPI 1 decreases the GLI1 mRNA expression. HPI 1 inhibits colony formation in a dose-dependent manner.
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GC47435
HPI-1 (hydrate)
A Hedgehog pathway inhibitor
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GC47474
Itraconazole-d5
R51211-d5
An internal standard for the quantification of itraconazole -
GC74091
Itraconazole-d9
R51211-d9
Itraconazole-d9 is the deuterium labeled Itraconazole. -
GC11111
Jervine
NSC 7520, NSC 23898
Hedgehog signaling Inhibitor -
GC15256
JK 184
Hh signaling inhibitor
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GC47570
Lipoxygenin
An inhibitor of 5-LO
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GC15683
LY2940680
Taladegib
LY2940680 (LY2940680) is an antagonist of the smoothened receptor. -
GC13630
MK-4101
Hedgehog (Hh) signaling pathway inhibitor
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GC44458
N-Palmitoyl-L-Aspartate
BRN 2295471
N-Palmitoyl-L-aspartate is a natural N-acylaspartate that inhibits Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. -
GC44321
Nat-20(S)-yne
Click Tag Nat-20(S)-yne
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. -
GC38522
Neurodazine
Small molecule inducer of neuronal differentiation
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GC17713
Oxy-16
20(R),22(R)-dihydroxy Cholesterol
Oxy-16 is an endogenous metabolic intermediate. -
GC13280
PF-5274857
Smo antagonist,potent and selective
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GC18475
Robotnikinin
Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper embryonic development.
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GC48062
RU-SKI 201 (hydrochloride)
A neuropeptide with diverse biological activities
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GC37573
RU-SKI 43
RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity.
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GC44855
RU-SKI 43 (hydrochloride)
An inhibitor of hedgehog acyltransferase
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GC91424
S1PL-IN-31
Sphingosine-1-Phosphate Lyase Inhibitor 31; S1PL Inhibitor 31; S1P Lyase Inhibitor 31
S1PL-IN-31 is an inhibitor of sphingosine-1-phosphate (S1P) lyase (IC50 = 210 nM). -
GC12068
SAG
Smoothened Agonist
SAG (Smoothened Agonist) is an effective Smo receptor agonist. -
GC15889
SANT-1
Shh inhibitor,potent and cell-permeable
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GC11193
SANT-2
SANT-2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT-2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers.
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GC73310
SMO-IN-2
SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway.
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GC45090
Triparanol
MER-29, NSC 65345
Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 μM), which is an enzyme involved in the biosynthesis of cholesterol. -
GC15284
U 18666A
U18666A is a small molecule with cellular permeability and amphiphilism that inhibits 3β-hydroxysterol-Δ (24)-reductase (DHCR24) activity, thereby preventing cholesterol outflow from late endosomes and lysosomes.