Hedgehog
Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.
Products for Hedgehog
- Cat.No. Product Name Information
- GC49651 19-alkyne Cholesterol An alkyne derivative of cholesterol for click chemistry
- GC15422 20(S)-Hydroxycholesterol An allosteric activator of the oncoprotein smoothened (Smo)
- GC66390 3-epi-Vitamin D3 3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells.
- GC12429 AY 9944 dihydrochloride AY 9944 dihydrochloride is a specific cholesterol biosynthesis inhibitor.
- GC14715 AZ 12080282 dihydrochloride Hedgehog inhibitor
- GC17153 CHIR-99021 (CT99021) HCl Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy.
-
GC11476
Ciliobrevin A
Hh pathway antagonist
- GC39359 Ciliobrevin D Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro.
- GC11217 CUR 61414 potent inhibitor of hedgehog-induced cellular activity
- GC13441 Cyclopamine Hedgehog (Hh) signaling Inhibitor
- GC43346 Cyclopamine-KAAD Cyclopamine-KAAD, a hedgehog signaling inhibitor, is a smoothened antagonist.
- GC16789 GANT 58 An inhibitor of Gli transcription
-
GC10359
GANT61
GANT61 was able to efficiently block GLI1 as well as GLI2-induced transcription, IC50 is 5 µM.
- GC10493 GDC-0449 (Vismodegib)
- GC43809 Hedgehog Antagonist VIII Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened.
- GC64134 Hh-Ag1.5 Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM.
- GC11045 HPI 1 HPI 1 is a potent GLI antagonist with an IC50 value of 1.1 μM. HPI 1 shows anti-proliferative activity. HPI 1 decreases the GLI1 mRNA expression. HPI 1 inhibits colony formation in a dose-dependent manner.
- GC47435 HPI-1 (hydrate) A Hedgehog pathway inhibitor
- GC47474 Itraconazole-d5 An internal standard for the quantification of itraconazole
- GC11111 Jervine Hedgehog signaling Inhibitor
- GC15256 JK 184 Hh signaling inhibitor
- GC47570 Lipoxygenin An inhibitor of 5-LO
- GC15683 LY2940680 LY2940680 (LY2940680) is an antagonist of the smoothened receptor.
- GC13630 MK-4101 Hedgehog (Hh) signaling pathway inhibitor
- GC44458 N-Palmitoyl-L-Aspartate N-Palmitoyl-L-aspartate is a natural N-acylaspartate that inhibits Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog.
- GC44321 Nat-20(S)-yne Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.
- GC38522 Neurodazine Small molecule inducer of neuronal differentiation
- GC17713 Oxy-16 Oxy-16 is an endogenous metabolic intermediate.
- GC13280 PF-5274857 Smo antagonist,potent and selective
- GC18475 Robotnikinin Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper embryonic development.
- GC37573 RU-SKI 43 RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity.
- GC44855 RU-SKI 43 (hydrochloride) An inhibitor of hedgehog acyltransferase
- GC12068 SAG Hh and Smo agonist
- GC15889 SANT-1 Shh inhibitor,potent and cell-permeable
- GC11193 SANT-2 SANT-2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT-2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers.
- GC45090 Triparanol Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 μM), which is an enzyme involved in the biosynthesis of cholesterol.
-
GC15284
U 18666A
U18666A can inhibit 3β-hydroxysterol-Δ (24)-reductase (DHCR24) activity, thereby preventing cholesterol outflow from late endosomes and lysosomes.