Wnt/β-catenin
β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).
Products for Wnt/β-catenin
- Cat.No. Product Name Information
- GC17764 Wnt agonist 1 Wnt agonist 1 is a potent and cell-permeable Wnt signaling activator. Wnt agonist 1 induces TCF-dependent transcriptional activity with an EC50of 700 nM.
-
GC70148
Wnt pathway activator 2
Wnt pathway activator 2 is an effective Wnt activator with an EC50 value of 13 nM. For more information, please refer to patent WO2012024404A1, compound 2.
- GC13658 Wnt-C59 PORCN inhibitor,highly potent and selective
- GC37937 Wnt/β-catenin agonist 1 Wnt/β-catenin agonist 1 (compound 3f) is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM.
- GC63695 Wnt/β-catenin agonist 2 Wnt/β-catenin agonist 2 is a potent Wnt agonist.
- GC66039 Wnt/β-catenin agonist 3 Wnt/β-catenin agonist 3 (compound 98) is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis.
-
GC70149
Wnt/β-catenin agonist 3 hydrochloride
Wnt/β-catenin agonist 3 hydrochloride is a Wnt/β-catenin signaling pathway activator. Wnt/β-catenin agonist 3 (compound 98) can be used for research on osteoporosis.
- GC68028 Wnt/β-catenin agonist 4
- GN10017 Wogonin
- GC12781 XAV-939 XAV-939 selectively inhibits β-catenin-mediated transcription.
- GC63303 YB-0158 YB-0158 is known as Wnt pathway inhibitor 2.
- GC45596 YW1128
- GC63560 ZW4864 ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM.
- GC63559 ZW4864 free base ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM.