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Home >> Signaling Pathways >> TGF-β / Smad Signaling

TGF-β / Smad Signaling

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Targets for  TGF-β / Smad Signaling

Products for  TGF-β / Smad Signaling

  1. Cat.No. Product Name Information
  2. GC17901 Tamoxifen Tamoxifen(TAM) serves as a selective estrogen receptor regulator (SERM), inhibiting estrogen's effects in breast cells while potentially stimulating estrogen activity in cells found in different tissues. Tamoxifen Chemical Structure
  3. GC10682 TAS 301

    inhibitor of smooth muscle cell migration and proliferation, inhibits PKC signaling

     TAS 301 Chemical Structure
  4. GC11181 Thiazovivin

    Tzv

     ROCK inhibitor Thiazovivin Chemical Structure
  5. GC73226 THK01 THK01 is a potent ROCK2 inhibitor with IC50 values of 5.7 and 923 nM for ROCK2 and ROCK1, respectively. THK01 Chemical Structure
  6. GC73292 THRX-144644 THRX-144644 is a Lung-restricted ALK5 inhibitor with an IC50 value of 0.14 nM. THRX-144644 Chemical Structure
  7. GC26000 TP0427736 HCl TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 HCl Chemical Structure
  8. GC70050 Trabedersen

    AP 12009

    Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen can be used to study malignant brain tumors and other solid tumors that overexpress TGF-β2, such as skin, pancreatic, and colon tumors.

     Trabedersen Chemical Structure
  9. GC73087 Trabedersen sodium

    AP 12009 sodium

     Trabedersen sodium is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen sodium Chemical Structure
  10. GC40928 Trimethylamine N-oxide

    TMAO

     Trimethylamine N-oxide (TMAO) is a product of the oxidation of TMA by flavin-containing mono-oxygenase 3 in the liver. Trimethylamine N-oxide Chemical Structure
  11. GC16678 UCN-02

    7-epi-hydroxy Staurosporine

     protein kinase C inhibitor UCN-02 Chemical Structure
  12. GC37880 Vactosertib Hydrochloride

    EW-7197 Hydrochloride; TEW-7197 Hydrochloride

     Vactosertib Hydrochloride (EW-7197 Hydrochloride) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib Hydrochloride has potently antimetastatic activity and anticancer effect. Vactosertib Hydrochloride Chemical Structure
  13. GC16934 Valrubicin

    NSC 246131, N-Trifluoroacetyladriamycin-14-valerate

     chemotherapy drug used to treat bladder cancer Valrubicin Chemical Structure
  14. GC70110 Vamotinib

    PF-114

    Vamotinib (PF-114) is an effective, selective and orally active tyrosine kinase inhibitor. Vamotinib inhibits the self-phosphorylation of BCR/ABL and BCR/ABL-T315I. Vamotinib induces apoptosis. Vamotinib exhibits anti-proliferative and anti-tumor activity. Vamotinib has potential in the study of resistant Philadelphia chromosome-positive (Ph+) leukemia.

     Vamotinib Chemical Structure
  15. GC71894 Vanicoside A Vanicoside A is a protein kinase C(PKC) inhibitor from Polygonum pensylvanicum. Vanicoside A Chemical Structure
  16. GC13232 Verbascoside

    Acteoside, NSC 603831

     PKC/NF-κB inhibitor Verbascoside Chemical Structure
  17. GC72283 Vicatertide Vicatertide is a TGF beta-1 inhibitor. Vicatertide Chemical Structure
  18. GC31912 VTX-27 VTX-27 is a selective protein kinase C θ (PKC θ) inhibitor, with Kis of 0.08 nM and 16 nM for PKC θ and PKC δ. VTX-27 Chemical Structure
  19. GC26055 WAY-301398

    6-methoxynaphthalene

     WAY-301398 (6-methoxynaphthalene) can bind to protein kinase C (PKC). WAY-301398 Chemical Structure
  20. GC26065 WAY-354831 WAY-354831 exhibits antibacterial activity. WAY-354831 Chemical Structure
  21. GC10970 WP1130

    WP 1130; WP-1130

     WP1130 (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. WP1130 has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2. WP1130 Chemical Structure
  22. GC62146 XST-14 XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects. XST-14 Chemical Structure
  23. GC15712 Y-27632

    A ROCK inhibitor,potent and selective

     Y-27632 Chemical Structure
  24. GC37947 Y-33075

    RKI-983, SNJ-1656, Y-39983

     Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM. Y-33075 Chemical Structure
  25. GC13423 Y-39983 dihydrochloride ROCK family inhibitor Y-39983 dihydrochloride Chemical Structure
  26. GC70166 Z-Arg-SBzl

    Z-Arg-SBzl is a substrate for activating protein C in both cows and humans.

     Z-Arg-SBzl Chemical Structure
  27. GC71056 Zelasudil Zelasudil is a Rho-associated (ROCK) kinase inhibitor. Zelasudil Chemical Structure
  28. GC33120 ZINC00881524 A ROCK inhibitor ZINC00881524 Chemical Structure
  29. GC13273 ZIP ZIP is a selective peptide inhibitor of PKMζ. ZIP Chemical Structure
  30. GC13461 ZIP (SCRAMBLED)

    z-Pseudosubstrate inhibitory peptide

     PKMζ inhibitor ZIP (SCRAMBLED) Chemical Structure
  31. GC16510 ZIP, Biotinylated ZIP with a biotin moiety covalently attached ZIP, Biotinylated Chemical Structure
  32. GC14701 Zoledronic Acid Potent nitrogen-containing bisphosphonates Zoledronic Acid Chemical Structure
  33. GC17727 [Ala107]-MBP (104-118) Non-competitive inhibitor of PKC [Ala107]-MBP (104-118) Chemical Structure
  34. GC15345 [Ala113]-MBP (104-118) Non-competitive inhibitor of PKC [Ala113]-MBP (104-118) Chemical Structure
  35. GC10343 α-Amyloid Precursor Protein Modulator α-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam-derived protein kinase C (PKC) activator with a Ki of 11.9 nM. α-Amyloid Precursor Protein Modulator Chemical Structure
  36. GC62478 ζ-Stat

    NSC37044

     ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro. ζ-Stat Chemical Structure

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