BMX Kinase
Bmx kinase is a member of Tec kinase family. It is involved in different signaling pathways and controls differential and tumorigenicity in several cancer types.
Products for BMX Kinase
- Cat.No. Product Name Information
- GC11063 BMX-IN-1 A selective BMX and BTK inhibitor
- GC33020 CHMFL-BMX-078 (CHMFL-BMX 078) CHMFL-BMX-078 (CHMFL-BMX 078) is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.
- GC35684 CHMFL-EGFR-202 CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC50s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL-EGFR-202 exhibits ?10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 adopts a covalent “DFG-in-C-helix-out” inactive binding conformation with EGFR, with strong antiproliferative effects against EGFR mutant-driven nonsmall-cell lung cancer (NSCLC) cell lines.