BMX Kinase

Bmx kinase is a member of Tec kinase family. It is involved in different signaling pathways and controls differential and tumorigenicity in several cancer types.

Products for BMX Kinase

Cat.No. Product Name Information
GC11063 BMX-IN-1

BMX Inhibitor 1
A selective BMX and BTK inhibitor
GC33020 CHMFL-BMX-078 (CHMFL-BMX 078)

CHMFL-BMX 078
CHMFL-BMX-078 (CHMFL-BMX 078) is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.
GC35684 CHMFL-EGFR-202 CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC50s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL-EGFR-202 exhibits ?10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 adopts a covalent “DFG-in-C-helix-out” inactive binding conformation with EGFR, with strong antiproliferative effects against EGFR mutant-driven nonsmall-cell lung cancer (NSCLC) cell lines.