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EGFR

EGFR (epidermal growth factor receptor) is the cell-surface receptor of its specific ligands, including epidermal growth factor and TGFα (transforming growth factor α) and is a receptor tyrosine kinase.

Products for  EGFR

  1. Cat.No. Product Name Information
  2. GC15589 WHI-P154 A JAK3 inhibitor WHI-P154  Chemical Structure
  3. GC16000 WHI-P180 EGFR/Janus Kinase 3 inhibitor WHI-P180  Chemical Structure
  4. GC37933 WHI-P180 hydrochloride WHI-P180 (Janex 3) is a multi-kinase inhibitor; inhibits RET, KDR and EGFR with IC50s of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 hydrochloride  Chemical Structure
  5. GC13213 WZ3146 Mutant EGFR inhibitor, potent and irreversible WZ3146  Chemical Structure
  6. GC15494 WZ4002 Mutant-selective EGFR inhibitor(L858R,T790M), irreversible and potent WZ4002  Chemical Structure
  7. GC11250 WZ8040 EGFR T790M inhibitor,irreversible amd potent WZ8040  Chemical Structure
  8. GC70164 Zalutumumab

    Zalutumumab is a highly affinity pure human IgG1 monoclonal antibody that targets EGFR. Zalutumumab binds to domain III of the epidermal growth factor receptor, exerting its effects by blocking the binding of epidermal growth factor and interfering with the receptor's active conformation. The EC50 values for Zalutumumab with IgG and its Fab regions are 7 and 19 nM, respectively. Zalutumumab can be used in cancer research.

    Zalutumumab  Chemical Structure
  9. GC70165 Zanidatamab

    Zanidatamab (ZW25) is a human bispecific monoclonal antibody targeting 2 different HER2 epitopes (ECD2 and ECD4). Zanidatamab has anti-tumor activity.

    Zanidatamab  Chemical Structure
  10. GC33171 ZD-4190 ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer. ZD-4190  Chemical Structure
  11. GC70169 Zenocutuzumab

    Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody that contains two different Fab arms targeting the extracellular domains of HER2 and HER3.

    Zenocutuzumab  Chemical Structure

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