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Home >> Signaling Pathways >> Tyrosine Kinase >> FAK

FAK

FAK (focal adhesion kinase), also known as PTK2, is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes.

Products for  FAK

  1. Cat.No. Product Name Information
  2. GC68626 Adhesamine

    Adhesamine is a dumbbell-shaped molecule that can activate the MAPK/FAK pathway. Adhesamine promotes adhesion and growth of mammalian cells. Adhesamine accelerates differentiation of primary cultured mouse hippocampal neurons and improves survival rate.

     Adhesamine Chemical Structure
  3. GC72932 Adhesamine diTFA Adhesamine diTFA is a dumbbell-shaped molecule that activates the MAPK/FAK pathway. Adhesamine diTFA Chemical Structure
  4. GC64015 AMP-945

    AMP-945

     AMP-945 is an inhibitor of the enzyme focal adhesion kinase (FAK). AMP-945 Chemical Structure
  5. GC64377 Batatasin III Batatasin III, a stilbenoid, inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition (EMT) and FAK-AKT signals. Batatasin III has anti-cancer activities. Batatasin III Chemical Structure
  6. GC65457 BI-3663 BI-3663 is a highly selective PTK2/FAK PROTAC (DC50=30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 linked to Pomalidomide with a linker. Anti-cancer activity. BI-3663 Chemical Structure
  7. GC34488 BI-4464 BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC. BI-4464 Chemical Structure
  8. GC65886 BI-853520

    IN-10018

     BI 853520 (IN-10018) is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC50=1nM). BI 853520 shows anti-proliferative activity against cancer cells. BI-853520 Chemical Structure
  9. GC15273 CEP-37440 FAK/ALK inhibitor,potent and selective CEP-37440 Chemical Structure
  10. GC32979 Chloropyramine hydrochloride Chloropyramine hydrochloride is a histamine receptor H1 antagonist which can also inhibit the biochemical function of VEGFR-3 and FAK. Chloropyramine hydrochloride Chemical Structure
  11. GC35728 Conteltinib

    CT-707

     Conteltinib (CT-707) is a multi-kinase inhibitor targeting FAK, ALK, and Pyk2. Conteltinib exerts significant inhibitory effect on FAK with an IC50 of 1.6 nM. Conteltinib Chemical Structure
  12. GC16813 Defactinib

    PF-04554878, VS-6063

    FAK phosphorylation inhibitor

     Defactinib Chemical Structure
  13. GC35827 Defactinib hydrochloride

    VS-6063 hydrochloride; PF 04554878 hydrochloride

     A novel FAK inhibitor Defactinib hydrochloride Chemical Structure
  14. GC12174 FAK Inhibitor 14

    Focal Adhesion Kinase Inhibitor 14, NSC 667249, NSC 677249, Y15

     FAK Inhibitor 14 is a potent and specific inhibitor of focal adhesion kinase (FAK) that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth. FAK Inhibitor 14 Chemical Structure
  15. GC36025 FAK inhibitor 2 FAK inhibitor 2 is a potent focal adhesion kinase (FAK) inhibitor with an IC50 ?of 0.07?nM, with antitumor and anti-angiogenesis activities. FAK inhibitor 2 Chemical Structure
  16. GC73575 FAK-IN-14 FAK-IN-14 (compound 8d) is a focal adhesion kinase(FAK) inhibitor with an IC50 value of 0.2438 nM. FAK-IN-14 Chemical Structure
  17. GC68030 FAK-IN-7 FAK-IN-7 Chemical Structure
  18. GC38437 Fangchinoline

    7-O-Demethyltetrandrine, Hanfangchin B, NSC 77036

     An alkaloid with diverse biological activities Fangchinoline Chemical Structure
  19. GC73149 FLT3-IN-17 FLT3-IN-17 inhibits CYPs and FLT3 mutants activity (IC50s: <0.5 nM for D835Y). FLT3-IN-17 Chemical Structure
  20. GC64888 GSK215 GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader with a pDC50 of 8.4. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect. GSK215 Chemical Structure
  21. GC19179 GSK2256098 GSK2256098 is a selective FAK kinase inhibitor, which inhibits growth and survival of pancreatic ductal adenocarcinoma cells. GSK2256098 Chemical Structure
  22. GC13410 Masitinib (AB1010)

    AB-1010, Masican, Masiviera

     Masitinib (AB1010) (AB1010) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib (AB1010) (AB1010) has anti-proliferative, pro-apoptotic activity and low toxicity. Masitinib (AB1010) Chemical Structure
  23. GC33045 NAMI-A NAMI-A is a ruthenium-based drug characterised by the selective activity against tumour metastases, inhibits the adhesion and migration. NAMI-A Chemical Structure
  24. GC44605 Petunidin (chloride)

    Petunidol

    Petunidin is an O-methylated anthocyanidin derived from delphinidin that imparts blue-red pigments to flowers, fruits, and red wine.

     Petunidin (chloride) Chemical Structure
  25. GC14767 PF-00562271

    PF-562271;PF00562271;PF62271

     PF-562271 (VS-6062) besylate is a potent ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase, with an IC50 of 1.5 nM and 13 nM, respectively. PF-00562271 Chemical Structure
  26. GC14407 PF-431396 Pyk2 and FAK inhibitor PF-431396 Chemical Structure
  27. GC15380 PF-562271

    PF562271;PF 562271

     PF-562271 is a potent small-molecule inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) with a IC50 of 1.5 and 14nmol/L, respectively. PF-562271 Chemical Structure
  28. GC10810 PF-562271 HCl

    PF562271 HCl;PF 562271 HCl

     PF-562271 (VS-6062) hydrochloride is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively. PF-562271 HCl Chemical Structure
  29. GC11107 PF-573228

    FAK Inhibitor II, Focal Adhesion Kinase Inhibitor II

     ATP-competitive FAK inhibitor PF-573228 Chemical Structure
  30. GC15164 PND-1186

    SR 2516, VS-4718

     A potent FAK inhibitor PND-1186 Chemical Structure
  31. GC62111 PND-1186 hydrochloride

    VS-4718 hydrochloride; SR-2516 hydrochloride

     PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis. PND-1186 hydrochloride Chemical Structure
  32. GC36985 PROTAC FAK degrader 1 PROTAC FAK degrader 1 is a selective and potent von Hippel-Lindau-based focal adhesion kinase (FAK) degrader with an IC50 of 6.5 nM, DC50 of 3 nM. PROTAC FAK degrader 1 Chemical Structure
  33. GC73424 PRT062607 acetate

    P505-15 acetate; PRT-2607 acetate; BIIB-057 acetate

     PRT062607 (P505-15) acetate is an orally available Syk inhibitor (IC50: 1 nM) that inhibits inflammation and induction Apoptosis. PRT062607 acetate Chemical Structure
  34. GC74116 Pyk2-IN-2 Pyk2-IN-2 (compound 13j) is an inhibitor of Pyk2 with an IC50 of FAK kinase of 0.608 μM. Pyk2-IN-2 Chemical Structure
  35. GC17500 SU6656 Src tyrosine kinases inhibitor SU6656 Chemical Structure
  36. GC16821 TAE226(NVP-TAE226)

    TAE 226;TAE-226

     TAE226(NVP-TAE226) (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. TAE226(NVP-TAE226) Chemical Structure
  37. GC68463 ULK1-IN-2 ULK1-IN-2 Chemical Structure
  38. GC14489 Y 11

    FAK Inhibitor 10

    focal adhesion kinase (FAK) inhibitor

     Y 11 Chemical Structure
  39. GC64992 YH-306 YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization. YH-306 Chemical Structure
  40. GC73041 ZINC40099027 ZINC40099027 is a FAK activator. ZINC40099027 Chemical Structure

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