ITK
ITK (IL2-inducible T-cell kinase) is an intracellular tyrosine kinase that regulates adaptive immune response. It functions in T-cell development and differentiation.
Products for ITK
- Cat.No. Product Name Information
- GC10455 BMS-509744
- GC50076 CTA 056 ITK inhibitor
- GC32053 GNE-4997 GNE-4997 is a potent and selective interleukin-2-inducible T-cell kinase (ITK) inhibitor with a Ki of 0.09 nM, and the correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects reduces cytotoxicity.
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GC69183
GNE-9822
GNE-9822 is an orally effective selective inhibitor of ITK with a Ki value of 0.7 nM. GNE-9822 has good ADME properties and can be used for research on asthma.
- GC50156 GSK 2250665A Itk inhibitor
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GC12167
ITK inhibitor
Potent ITK inhibitor
- GC36354 ITK inhibitor 2 ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor extracted from patent WO2011065402A1, compound 4, with an IC50 of 2 nM.
- GC17630 PF 06465469 inhibitor of interleukin-2 inducible T cell kinase (ITK) and Bruton's tyrosine kinase (BTK)
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GC30502
PRN694
PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0.3 nM and 1.4 nM, respectively.
- GC34077 Vecabrutinib (SNS-062) Vecabrutinib (SNS-062) (SNS-062) is a potent, noncovalent BTK and ITK inhibitor, with Kd values of 0.3 nM and 2.2 nM, respectively. Vecabrutinib (SNS-062) shows an IC50 of 24 nM for ITK.