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Home >> Signaling Pathways >> Tyrosine Kinase >> ITK

ITK

ITK (IL2-inducible T-cell kinase) is an intracellular tyrosine kinase that regulates adaptive immune response. It functions in T-cell development and differentiation.

Products for  ITK

  1. Cat.No. Product Name Information
  2. GC10455 BMS-509744 BMS-509744 Chemical Structure
  3. GC50076 CTA 056 ITK inhibitor CTA 056 Chemical Structure
  4. GC32053 GNE-4997 GNE-4997 is a potent and selective interleukin-2-inducible T-cell kinase (ITK) inhibitor with a Ki of 0.09 nM, and the correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects reduces cytotoxicity. GNE-4997 Chemical Structure
  5. GC69183 GNE-9822

    GNE-9822 is an orally effective selective inhibitor of ITK with a Ki value of 0.7 nM. GNE-9822 has good ADME properties and can be used for research on asthma.

     GNE-9822 Chemical Structure
  6. GC50156 GSK 2250665A Itk inhibitor GSK 2250665A Chemical Structure
  7. GC12167 ITK inhibitor

    Potent ITK inhibitor

     ITK inhibitor Chemical Structure
  8. GC36354 ITK inhibitor 2 ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor extracted from patent WO2011065402A1, compound 4, with an IC50 of 2 nM. ITK inhibitor 2 Chemical Structure
  9. GC17630 PF 06465469 inhibitor of interleukin-2 inducible T cell kinase (ITK) and Bruton's tyrosine kinase (BTK) PF 06465469 Chemical Structure
  10. GC30502 PRN694

    PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0.3 nM and 1.4 nM, respectively.

     PRN694 Chemical Structure
  11. GC34077 Vecabrutinib (SNS-062) Vecabrutinib (SNS-062) (SNS-062) is a potent, noncovalent BTK and ITK inhibitor, with Kd values of 0.3 nM and 2.2 nM, respectively. Vecabrutinib (SNS-062) shows an IC50 of 24 nM for ITK. Vecabrutinib (SNS-062) Chemical Structure

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