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Home >> Signaling Pathways >> Tyrosine Kinase >> ROR

ROR

ROR (RAR-related orphan receptor) is a nuclear receptor family of intracellular transcription factors and appears to bind as monomers to hormone response elements.

Products for  ROR

  1. Cat.No. Product Name Information
  2. GC35214 A-9758 A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 Chemical Structure
  3. GC73077 ARI-1 ARI-1 is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor. ARI-1 Chemical Structure
  4. GC72825 ASN06917370 ASN06917370 is a former orphan receptor GPR17 ligand for the study of neurodegenerative diseases. ASN06917370 Chemical Structure
  5. GC31880 AZD-0284 AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 Chemical Structure
  6. GC63436 Bevurogant

    BI 730357

     Bevurogant (BI 730357) is a retinoid-related orphan receptor-gamma t (RORγt) antagonist. Bevurogant Chemical Structure
  7. GC63458 Cedirogant

    ABBV-157

     Cedirogant (ABBV-157) is an orally active RORγt inverse agonist. Cedirogant Chemical Structure
  8. GC32713 Cintirorgon (LYC-55716)

    LYC-55716

     Cintirorgon (LYC-55716) (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival. Cintirorgon (LYC-55716) Chemical Structure
  9. GC47182 Dehydrolithocholic Acid

    3-keto LCA, 3-keto Lithocholate, 3-keto Lithocholic Acid, 3-KLCA, 3-oxo LCA, 3-oxo Lithocholate, 3-oxo Lithocholic Acid

     Dehydrolithocholic Acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM). Dehydrolithocholic Acid Chemical Structure
  10. GC31871 GNE-0946 GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell. GNE-0946 Chemical Structure
  11. GC33882 GNE-6468 GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 Chemical Structure
  12. GC13905 GSK2981278 RORγ-selective inverse agonist GSK2981278 Chemical Structure
  13. GC18591 GSK805 GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA binding. GSK805 Chemical Structure
  14. GC69318 JNJ-61803534

    JNJ-61803534 is an effective and orally active RORγt inverse agonist with an IC50 of 9.6 nM. It has anti-inflammatory activity and inhibits the production of IL-17A in human CD4+ T cells under Th17 differentiation conditions.

     JNJ-61803534 Chemical Structure
  15. GC32044 L 601920-0 (Methyl-3β-hydroxycholenate) L 601920-0 (Methyl-3β-hydroxycholenate) is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2. L 601920-0 (Methyl-3β-hydroxycholenate) Chemical Structure
  16. GC47687 ML-209 An RORγt antagonist ML-209 Chemical Structure
  17. GC69496 MRL-871

    MRL-871 (compound 3) is an effective inverse agonist of retinoic acid receptor-related orphan receptor gamma t (RORγt), with an IC50 of 264 nM. MRL-871 has a unique imidazole chemical structure and can effectively reduce the generation of IL-17a mRNA in EL4 cells.

     MRL-871 Chemical Structure
  18. GC10644 Neoruscogenin

    25(27)-Dehydroruscogenin

     nuclear receptor RORα agonist Neoruscogenin Chemical Structure
  19. GN10325 Nobiletin

    NSC 76751, NSC 618903

     Nobiletin Chemical Structure
  20. GC34710 PF-06747711 PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. PF-06747711 Chemical Structure
  21. GC37556 ROR agonist-1 ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5. ROR agonist-1 Chemical Structure
  22. GC69830 RORγt agonist 3

    RORγt agonist 2 is an effective RORγt activator. It promotes Th17 cell differentiation, increases pro-inflammatory cytokine levels, and enhances lymphocyte cytotoxicity. RORγt agonist 2 inhibits the production of regulatory T cells, thereby suppressing immune responses (extracted from patent WO2021136326A1, compound 23).

     RORγt agonist 3 Chemical Structure
  23. GC68411 RORγt Inverse agonist 10 RORγt Inverse agonist 10 Chemical Structure
  24. GC62349 RORγt inverse agonist 13 RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM. RORγt inverse agonist 13 Chemical Structure
  25. GC65953 RORγt inverse agonist 23 RORγt inverse agonist 23 is a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist. RORγt inverse agonist 23 Chemical Structure
  26. GC37557 RORγt Inverse agonist 3 RORγt Inverse agonist 3 Chemical Structure
  27. GC62623 RORγt Inverse agonist 6 RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 Chemical Structure
  28. GC65155 S18-000003 S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of <30 nM towards human RORγt in competitive binding assays. S18-000003 Chemical Structure
  29. GC14054 SR 0987 agonist of the T cell-specific isoform of RORγ SR 0987 Chemical Structure
  30. GC15009 SR 1001 RORα and γ inverse agonist SR 1001 Chemical Structure
  31. GC14418 SR 1555 (hydrochloride) inverse agonist of RORγ SR 1555 (hydrochloride) Chemical Structure
  32. GC14284 SR 2211 inverse agonist of RORγ, potent and selective SR 2211 Chemical Structure
  33. GC16392 SR1078

    SR 1078;SR-1078

     A selective RORα/RORγ agonist SR1078 Chemical Structure
  34. GC12877 SR3335

    ML 176

     A selective inverse agonist of RORα SR3335 Chemical Structure
  35. GC31163 TMP778

    TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay.

     TMP778 Chemical Structure
  36. GC62520 TMP780 TMP780 is an inverse agonist of RORγt with an IC50 of 13 nM. TMP780 Chemical Structure
  37. GC39299 TMP920 TMP920 is a highly potent and selective RORγt antagonist. TMP920 Chemical Structure
  38. GC31533 Vimirogant (VTP-43742) Vimirogant (VTP-43742) (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant (VTP-43742) Chemical Structure
  39. GC74028 W6134 W6134 is highly potent and selective RORγ covalent inhibitor with IC50 of 0.21 μM. W6134 Chemical Structure
  40. GC50389 XY 018 RORγ antagonist; inhibits AR expression XY 018 Chemical Structure
  41. GC37944 XY101 XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM. XY101 Chemical Structure
  42. GC66327 Zilovertamab

    UC-961; Cirmtuzumab

     Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling. Zilovertamab Chemical Structure

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