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Home >> Signaling Pathways >> Tyrosine Kinase >> Spleen Tyrosine Kinase (Syk)

Spleen Tyrosine Kinase (Syk)

Syk is a family of non-receptor cytoplasmic tyrosine kinases that plays a role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins.

Products for  Spleen Tyrosine Kinase (Syk)

  1. Cat.No. Product Name Information
  2. GC16389 BAY 61-3606 A Syk inhibitor BAY 61-3606 Chemical Structure
  3. GC12136 BAY 61-3606 dihydrochloride

    BAY61-3606 dihydrochloride;BAY 61-3606

     BAY 61-3606 dihydrochloride Chemical Structure
  4. GC11209 Cerdulatinib (PRT062070)

    PRT062070, PRT2070

     Cerdulatinib (PRT062070) (PRT062070) is a selective Tyk2 inhibitor with an IC50 of 0.5 nM. Cerdulatinib (PRT062070) (PRT062070) also is a dual JAK and SYK inhibitor with IC50s of 12, 6, 8 and 32 for JAK1, 2, 3 and SYK, respectively. Cerdulatinib (PRT062070) Chemical Structure
  5. GC63429 Cevidoplenib

    SKI-O-703

     Cevidoplenib (SKI-O-703) is an orally active and selective spleen tyrosine kinase (Syk) inhibitor. Cevidoplenib Chemical Structure
  6. GC63455 Cevidoplenib dimesylate

    SKI-O-703 dimesylate

     Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib dimesylate Chemical Structure
  7. GC70810 ER-27319 ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 Chemical Structure
  8. GC11044 Fostamatinib (R788) Fostamatinib (R788) is the oral prodrug of the active compound R406, a relatively selective small molecule inhibitor of Syk . Fostamatinib (R788) Chemical Structure
  9. GC16430 GS-9973

    GS-9973

     GS-9973 (GS-9973) is an orally bioavailable, selective Syk inhibitor with an IC50 of 7.7 nM. GS-9973 Chemical Structure
  10. GC68447 GSK143 dihydrochloride GSK143 dihydrochloride Chemical Structure
  11. GC64889 GSK2646264 GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.1. GSK2646264 Chemical Structure
  12. GC33041 Gusacitinib (ASN-002)

    ASN-002

     Gusacitinib (ASN-002) (ASN-002) is an orally active and potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM. Gusacitinib (ASN-002) has anti-cancer activity in both solid and hematological tumor types. Gusacitinib (ASN-002) Chemical Structure
  13. GC36423 Lanraplenib

    GS-9876, GS-SYK

     A Syk inhibitor Lanraplenib Chemical Structure
  14. GC38630 Lanraplenib succinate

    GS-9876 succinate

     Lanraplenib succinate (GS-9876 succinate) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib succinate Chemical Structure
  15. GC10048 MNS

    3,4Methylenedioxyβnitrostyrene, NSC 10120, NSC 105303, NSC 170724, Syk Inhibitor III

     Inhibitor of Src/Syk tyrosine kinases MNS Chemical Structure
  16. GN10503 Piceatannol

    Astringenin, transPicetannol, trans3,3',4,5'Tetrahydroxystilbene

     Piceatannol (3,3′,4,5′-trans-trihydroxystilbene) is a naturally occurring hydroxylated analogue of resveratrol. Piceatannol Chemical Structure
  17. GC11321 PRT-060318

    P142-76, PRT318

     novel Syk inhibitor PRT-060318 Chemical Structure
  18. GC25787 PRT-060318 2HCl

    PRT318

     PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment. PRT-060318 2HCl Chemical Structure
  19. GC31819 PRT062607 (P505-15)

    P505-15, PRT062607, PRT2607

     PRT062607 (P505-15)(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70. PRT062607 (P505-15) Chemical Structure
  20. GC73424 PRT062607 acetate

    P505-15 acetate; PRT-2607 acetate; BIIB-057 acetate

     PRT062607 (P505-15) acetate is an orally available Syk inhibitor (IC50: 1 nM) that inhibits inflammation and induction Apoptosis. PRT062607 acetate Chemical Structure
  21. GC10499 PRT062607 Hydrochloride

    PRT 062607 hydrochloride;PRT-062607 hydrochloride

     PRT062607 Hydrochloride Chemical Structure
  22. GC33874 R112 A Syk inhibitor R112 Chemical Structure
  23. GC16796 R406 SYK inhibitor,potent and ATP-competitive R406 Chemical Structure
  24. GC15658 R406(free base) Syk inhibitor R406(free base) Chemical Structure
  25. GC11811 R788 disodium

    Fostamatinib Disodium Hexahydrate;R 788;R-788

     R788 disodium (R788 Disodium) is the oral prodrug of the active compound R406. R788 disodium Chemical Structure
  26. GC15709 R788 disodium hexahydrate Fostamatinib (R788) disodium hexahydrate is the oral prodrug of the active compound R406. R788 disodium hexahydrate Chemical Structure
  27. GC15466 RO9021 Syk inhibitor RO9021 Chemical Structure
  28. GC64279 Sovleplenib

    HMPL-523

     Sovleplenib (HMPL-523) is a highly potent, orally available and selective SYK inhibitor with an IC50 of 25 nM. Anti-tumor activity. Sovleplenib can be used for the research of immune thrombocytopenia (ITP). Sovleplenib Chemical Structure
  29. GC62456 SRX3207 SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression. SRX3207 Chemical Structure
  30. GC44978 Syk Inhibitor II

    Spleen Tyrosine Kinase Inhibitor II

     Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs and mediates downstream signaling. Syk Inhibitor II Chemical Structure
  31. GC61942 Syk-IN-1 Syk-IN-1 (compound 4) is a potent Syk inhibitor, with an IC50 of 35 nM. Syk-IN-1 Chemical Structure
  32. GC62592 Syk-IN-4 Syk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC50 of 0.31 nM. Syk-IN-4 Chemical Structure
  33. GC37723 TAK-659 TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL). TAK-659 Chemical Structure
  34. GC19344 TAK-659 hydrochloride TAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM. TAK-659 hydrochloride Chemical Structure

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