Home >> Signaling Pathways >> Tyrosine Kinase >> TAM Receptor

TAM Receptor

TAM receptors (Tyro3, Axl, and Mer) belong to a family of receptor tyrosine kinases that have important effects on hemostasis and inflammation. TAM receptors affect cell proliferation, survival, adhesion, and migration. TAM receptors can be activated by the vitamin K-dependent proteins Gas6 and protein S. Protein S is more commonly known as an important cofactor for protein C as well as a direct inhibitor of multiple coagulation factors.

The TAM receptors-Tyro3, Axl, and Mer-comprise a unique family of receptor tyrosine kinases, in that as a group they play no essential role in embryonic development. TAM receptor signaling plays an especially important role in the engulfment and phagocytic clearance of apoptotic cells (ACs) and membranes in adult tissues.

Products for  TAM Receptor

  1. Cat.No. Product Name Information
  2. GC10408 2-D08 Sumoylation inhibitor
  3. GC14214 BMS-777607 C-Met inhibitor, potent and selective
  4. GC15779 Cabozantinib (XL184, BMS-907351) VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor
  5. GC19102 CEP-40783 CEP-40783 is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively.
  6. GC19482 Gilteritinib A potent FLT3/AXL inhibitor
  7. GC36135 Gilteritinib hemifumarate
  8. GC19166 Glesatinib hydrochloride Glesatinib hydrochloride is an inhibitor of the MET and Axl receptor tyrosine kinase pathways, which drive tumour growth when altered.
  9. GC14241 LDC1267 TAM kinase inhibitor,highly selective
  10. GC18211 Ningetinib
  11. GC36744 Ningetinib Tosylate
  12. GC14488 NPS-1034 MET inhibitor
  13. GC17618 R428 Selective Axl inhibitor
  14. GC33271 R916562
  15. GC38580 RU-301
  16. GC19330 SGI-7079 SGI-7079 is an Axl inhibitor, significantly inhibits the proliferation of SUM149 or KPL-4 cells with an IC50 of 0.43 or 0.16 uM, respectively.
  17. GC37733 TAM-IN-2
  18. GC14218 TP-0903 AXL receptor tyrosine kinase inhibitor, anti-cancer agent
  19. GC17793 UNC2250 Mer inhibitor,potent and selective
  20. GC37858 UNC2541
  21. GC13500 UNC2881 Mer tyrosine kinase inhibitor

20 Item(s)

per page

Set Descending Direction