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Home >> Signaling Pathways >> Tyrosine Kinase >> TAM Receptor

TAM Receptor

TAM receptors (Tyro3, Axl, and Mer) belong to a family of receptor tyrosine kinases that have important effects on hemostasis and inflammation. TAM receptors affect cell proliferation, survival, adhesion, and migration. TAM receptors can be activated by the vitamin K-dependent proteins Gas6 and protein S. Protein S is more commonly known as an important cofactor for protein C as well as a direct inhibitor of multiple coagulation factors.

The TAM receptors-Tyro3, Axl, and Mer-comprise a unique family of receptor tyrosine kinases, in that as a group they play no essential role in embryonic development. TAM receptor signaling plays an especially important role in the engulfment and phagocytic clearance of apoptotic cells (ACs) and membranes in adult tissues.

Targets for  TAM Receptor

Products for  TAM Receptor

  1. Cat.No. Product Name Information
  2. GC10408 2-D08 Sumoylation inhibitor 2-D08 Chemical Structure
  3. GC73370 AXL-IN-13 AXL-IN-13 is a potent and orally active AXL inhibitor (IC50: 1.6 nM, Kd: 0.26 nM). AXL-IN-13 Chemical Structure
  4. GC64071 AZ14145845 AZ14145845 is a highly selective type I1/2 dual Mer/Axl kinase inhibitor with in vivo efficacy. AZ14145845 Chemical Structure
  5. GC74513 Batiraxcept

    AVB-S6-500

     Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept Chemical Structure
  6. GC45830 BAY-1125976 An allosteric inhibitor of Akt1/2 BAY-1125976 Chemical Structure
  7. GC14214 BMS-777607

    BMS-817378

     BMS-777607 is a pan-TAM inhibitor, which shows anti-tumor activity to different types of cancer. BMS-777607 Chemical Structure
  8. GC15779 Cabozantinib (XL184, BMS-907351)

    BMS-907351, Cabozantinib

     Cabozantinib (XL184,BMS-907351) is a novel MET and VEGFR2 inhibitor that simultaneously inhibits metastasis, angiogenesis and tumor growth. Cabozantinib (XL184, BMS-907351) Chemical Structure
  9. GC19102 CEP-40783

    RXDX-106

     CEP-40783 is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively. CEP-40783 Chemical Structure
  10. GC62597 DS-1205b free base DS-1205b free base is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205b free base also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205b free base can inhibit cell migration in vitro and tumor growth in vivo. DS-1205b free base Chemical Structure
  11. GC69061 Enapotamab

    Anti-AXL/UFO Reference Antibody (enapotamab)

    Enapotamab is an AXL/UFO-related antibody that can be used to synthesize Bcl-xl inhibitor antibody activity molecule conjugates.

     Enapotamab Chemical Structure
  12. GC19482 Gilteritinib

    ASP2215

     Gilteritinib (ASP2215, Xospata) for relapsed and /or refractory AML (R/R AML). Gilteritinib Chemical Structure
  13. GC36135 Gilteritinib hemifumarate

    ASP2215 hemifumarate

     Gilteritinib (ASP2215) hemifumarate is a potent and ATP-competitive FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively. Gilteritinib hemifumarate Chemical Structure
  14. GC19166 Glesatinib hydrochloride

    MGCD265 hydrochloride

     Glesatinib hydrochloride is an inhibitor of the MET and Axl receptor tyrosine kinase pathways, which drive tumour growth when altered. Glesatinib hydrochloride Chemical Structure
  15. GC14241 LDC1267 TAM kinase inhibitor,highly selective LDC1267 Chemical Structure
  16. GC74578 Mipasetamab Mipasetamab is an IgG1κ antibody targeting to AXL, a tyrosine kinase receptor and an TAM Receptor. Mipasetamab Chemical Structure
  17. GC18211 Ningetinib A multi-kinase inhibitor Ningetinib Chemical Structure
  18. GC36744 Ningetinib Tosylate Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib Tosylate Chemical Structure
  19. GC14488 NPS-1034 MET inhibitor NPS-1034 Chemical Structure
  20. GC73128 PF-07265807 PF-07265807 is a potent TAM and c-Met kinase inhibitor with IC50 values of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. PF-07265807 Chemical Structure
  21. GC17618 R428

    R-428;R 428;BGB324

     R428, as a Axl inhibitor, blocks Axl autophosphorylation on its C-terminal docking site, Tyr821, at nanomolar concentrations[1]. R428 Chemical Structure
  22. GC33271 R916562 R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis. R916562 Chemical Structure
  23. GC38580 RU-301 RU-301 is a pan TAM inhibitor that blocks Gas6-induced TAM activation and tumorigenicity. RU-301 Chemical Structure
  24. GC64385 RU-302 RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth. RU-302 Chemical Structure
  25. GC19330 SGI-7079 SGI-7079 is an Axl inhibitor, significantly inhibits the proliferation of SUM149 or KPL-4 cells with an IC50 of 0.43 or 0.16 uM, respectively. SGI-7079 Chemical Structure
  26. GC37733 TAM-IN-2 TAM-IN-2 is a TAM inhibitor extracted from patent US 20170275290 A1, pyrrolotriazine compound 0904. TAM-IN-2 Chemical Structure
  27. GC68342 Tilvestamab

    BGB149

     Tilvestamab Chemical Structure
  28. GC67878 TL4830031 TL4830031 Chemical Structure
  29. GC14218 TP-0903

    TP-0903

     TP-0903 (TP-0903) is a potent and selective Axl receptor tyrosine kinase inhibitor with an IC50 value of 27 nM. TP-0903 Chemical Structure
  30. GC17793 UNC2250 Mer inhibitor,potent and selective UNC2250 Chemical Structure
  31. GC37858 UNC2541 UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 Chemical Structure
  32. GC13500 UNC2881 Mer tyrosine kinase inhibitor UNC2881 Chemical Structure
  33. GC62516 UNC5293 UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research. UNC5293 Chemical Structure
  34. GC62266 XL092

    XL092

     XL092 is an orally active, ATP-competitive inhibitor of multiple receptor tyrosine kinases (RTKs) including MET, VEGFR2, AXL and MER, with IC50s in cell-based assays of 15 nM, 1.6 nM, 3.4 nM, 7.2 nM respectively. XL092 exhibits anti-tumor activity. XL092 has the potential for kinase-dependent diseases and conditions research. XL092 Chemical Structure

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