Trk
Trk is a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.
Products for Trk
- Cat.No. Product Name Information
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GC19012
(R)-GNE-140
?A TRK kinase (TKI) inhibitor
- GC16853 7,8-Dihydroxyflavone Tyrosine kinase receptor B (TrkB) agonist
- GC16604 Altiratinib c-MET/TIE-2/VEGFR inhibitor
- GC11486 ANA 12 TrkB receptor antagonist
- GC33090 AZ-23 (AZ23) AZ-23 (AZ23) is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.
- GC12186 BDNF (human) activator of TrkB and p75 neurotrophin receptors
- GC19063 Belizatinib Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.
- GC32623 CE-245677 CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
- GC33112 CH7057288 CH7057288 is a potent and selective TRK inhibitor.
- GC13780 Cyclotraxin B TrkB receptor antagonist
- GC62597 DS-1205b free base DS-1205b free base is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205b free base also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205b free base can inhibit cell migration in vitro and tumor growth in vivo.
- GC14476 Entrectinib Orally active inhibitor of ALK kinase
- GC16343 GNF-5837 Pan-Trk inhibitor
- GC14123 GW441756 TrkA inhibitor,potent and selective
- GC50660 HIOC HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor.
- GC11362 K 252a A protein kinase inhibitor
- GC17835 LM 22A4 tropomyosin-related kinase B (TrkB) agonist
- GC30770 LM22B-10 An activator of TrkB and TrkC
- GC36425 LOXO-101 (Larotrectinib) LOXO-101 (Larotrectinib) (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
- GC15282 LOXO-101 (Larotrectinib) sulfate LOXO-101 (Larotrectinib) sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
- GC15365 N-Acetylserotonin N-Acetylserotonin is a Melatonin precursor, and that it can potently activate TrkB receptor.
- GC10720 NTR 368 cytoplasmic peptide of the neurotrophin receptor p75NTR
- GC50346 PF 06273340 Potent and selective pan-Trk inhibitor; peripherally restricted
- GC65009 PF-6683324 PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays withIC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively.
- GC19362 Repotrectinib TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.
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GC17622
Ro 08-2750
antagonist of nerve growth factor (NGF)
- GC32808 Selitrectinib (LOXO-195) Selitrectinib (LOXO-195) (LOXO-195) is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively.
- GC19332 Sitravatinib Sitravatinib is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth with IC50 of 3980 nmol/L.
- GC31676 Tavilermide (MIM-D3) Tavilermide (MIM-D3) is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.
- GC11496 TLQP 21
- GC60372 TrkA-IN-1 TrkA-IN-1 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 of 99 nM in a cell-based assay.
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GC70064
TrkA-IN-3
TrkA-IN-3 is an effective and sub-selective TrkA allosteric inhibitor with an IC50 value of 22.4 nM. TrkA-IN-3 exhibits a selectivity for TrkA over TrkB and TrkC by 8000-fold. It can be used in the study of pain.
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GC70065
TrkA-IN-4
TrkA-IN-4 is an effective and orally active TrkA allosteric inhibitor, which is a precursor of TrkA-IN-3. TrkA-IN-4 exhibits effective anti-injury activity.
- GC15271 Tyrphostin AG 879 HER2 inhibitor