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Home >> Signaling Pathways >> Tyrosine Kinase >> VEGFR

VEGFR

VEGFR are receptors for vascular endothelial growth factor and belong to receptor tyrosine kinases.

Products for  VEGFR

  1. Cat.No. Product Name Information
  2. GC17369 Sorafenib

    Sorafenib acts as a multi-kinase inhibitor, targeting Raf-1 and B-Raf with IC50 values of 6 nM and 22 nM, respectively.

     Sorafenib Chemical Structure
  3. GC37664 Sorafenib (D3) An internal standard for the quantification of sorafenib Sorafenib (D3) Chemical Structure
  4. GC37665 Sorafenib (D4) Sorafenib (D4) (Bay 43-9006-d4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively. Sorafenib (D4) Chemical Structure
  5. GC11417 SU 4312 VEGFR and PDGFR tyrosine kinases inhibitor SU 4312 Chemical Structure
  6. GC44958 SU 5205 SU 5205 is an inhibitor of VEGF receptor 2 (VEGFR2/FLK1; IC50 = 9.6 μM). SU 5205 Chemical Structure
  7. GC40755 SU 5214 SU 5214 is a 3-heteroaryl-2-indoline that was designed in a drug discovery program for development of tyrosine kinase inhibitors. SU 5214 Chemical Structure
  8. GC14660 SU 5402 An inhibitor of VEGFR2, FGFR1, and PDGFRβ SU 5402 Chemical Structure
  9. GC14733 SU14813 A dual VEGFR and PDGFR family kinase inhibitor SU14813 Chemical Structure
  10. GC11790 SU14813 double bond Z Tyrosine kinase inhibitor SU14813 double bond Z Chemical Structure
  11. GC14315 SU14813 maleate A dual VEGFR and PDGFR family kinase inhibitor SU14813 maleate Chemical Structure
  12. GC33840 SU1498 (AG 1498) SU1498 (AG 1498) (AG 1498) is a selective inhibitor of the VEGFR2; inhibits Flk-1 with an IC50 of value of 700 nM. SU1498 (AG 1498) Chemical Structure
  13. GC61780 SU5204 SU5204, a tyrosine kinase inhibitor, has IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively. SU5204 Chemical Structure
  14. GC25969 SU5208 SU5208(3-[(Thien-2-yl)methylene]-2-indolinone) is an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR2). SU5208 Chemical Structure
  15. GC32469 SU5408 (VEGFR2 Kinase Inhibitor I) SU5408 (VEGFR2 Kinase Inhibitor I) (VEGFR2 Kinase Inhibitor I) is a potent and cell-permeable inhibitor of VEGFR2 kinase with an IC50 of 70 nM. SU5408 (VEGFR2 Kinase Inhibitor I) Chemical Structure
  16. GC15307 SU5416

    A tyrosine kinase inhibitor

     SU5416 Chemical Structure
  17. GC32805 Sulfatinib (HMPL-012) Sulfatinib (HMPL-012) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC50s of in a range of 1 to 24 nM. Sulfatinib (HMPL-012) Chemical Structure
  18. GC17651 Sunitinib RTK inhibitor Sunitinib Chemical Structure
  19. GC48118 Sunitinib-d10 An internal standard for the quantification of sunitinib Sunitinib-d10 Chemical Structure
  20. GC10220 TAK-593 dual VEGFR/PDGFR inhibitor TAK-593 Chemical Structure
  21. GC49700 Takeda-6d Takeda-6d Chemical Structure
  22. GN10737 Tanshinone IIA Tanshinone IIA Chemical Structure
  23. GC69990 Tarcocimab

    Tarcocimab (OG1953) is a humanized monoclonal antibody (IgG1 type) against VEGFA. Tarcocimab can be used for research on retinal vein occlusion (RVO) and wet age-related macular degeneration (AMD).

     Tarcocimab Chemical Structure
  24. GC33173 TAS-115 TAS-115 (TAS-115) is a potent VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively. TAS-115 Chemical Structure
  25. GC33273 TAS-115 mesylate (TAS-115 methanesulfonate) Pamufetinib (TAS-115) mesylate is a potent VEGFRand hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor, with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively. TAS-115 mesylate (TAS-115 methanesulfonate) Chemical Structure
  26. GC11763 Telatinib (BAY 57-9352) Telatinib (BAY 57-9352) (Bay 57-9352) is an orally active, small molecule inhibitor of VEGFR2, VEGFR3, PDGFα, and c-Kit with IC50s of 6, 4, 15 and 1 nM, respectively. Telatinib (BAY 57-9352) Chemical Structure
  27. GC63214 Telatinib mesylate Telatinib mesylate (Bay 57-9352 mesylate) is a potent and orally active VEGFR2, VEGFR3, PDGFα, and c-Kit inhibitor with IC50s of 6 nM, 4 nM, 15 nM and 1 nM, respectively. Telatinib mesylate Chemical Structure
  28. GC31752 Tesevatinib (XL-647) Tesevatinib (XL-647) (XL-647; EXEL-7647; KD-019) is an orally available, multi-target tyrosine kinase inhibitor; inhibits EGFR, ErbB2, KDR, Flt4 and EphB4 kinase with IC50s of 0.3, 16, 1.5, 8.7, and 1.4 nM. Tesevatinib (XL-647) Chemical Structure
  29. GC37771 TG 100572 TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively. TG 100572 Chemical Structure
  30. GC37772 TG 100572 Hydrochloride TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively. TG 100572 Hydrochloride Chemical Structure
  31. GC11622 TG 100801 TG 100801 Chemical Structure
  32. GC37773 TG 100801 Hydrochloride TG 100801 Hydrochloride is a prodrug that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively. TG 100801 Hydrochloride Chemical Structure
  33. GC60365 TIE-2/VEGFR-2 kinase-IN-1 TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 Chemical Structure
  34. GC12036 Tivozanib (AV-951) Tivozanib (AV-951; KRN951) is a potent and selective and orally active VEGFR tyrosine kinase inhibitor with IC50是of 0.21, 0.16, 0.24 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively. Tivozanib inhibits angiogenesis and vascular permeability in tumor tissues and shows antitumor activity. Tivozanib has the potential for the research of metastatic renal cell carcinoma (RCC) . Tivozanib (AV-951) Chemical Structure
  35. GC15280 Tivozanib (hydrate) VEGFR inhibitor, orally available Tivozanib (hydrate) Chemical Structure
  36. GC64996 Tivozanib hydrochloride hydrate Tivozanib hydrochloride hydrate Chemical Structure
  37. GC10719 Toceranib A multi-targeted receptor tyrosine kinase inhibitor Toceranib Chemical Structure
  38. GC37808 Toceranib phosphate Toceranib phosphate (SU11654 phosphate) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR, VEGFR, and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib phosphate (SU11654 phosphate) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors . Toceranib phosphate Chemical Structure
  39. GC16732 TSU-68 (SU6668,Orantinib) TSU-68 (SU6668,Orantinib) (SU6668; TSU-68) is a multi-targeted receptor tyrosine kinase inhibitor with Kis of 2.1 μM, 8 nM and 1.2 μM for Flt-1, PDGFRβ and FGFR1, respectively. TSU-68 (SU6668,Orantinib) Chemical Structure
  40. GC34026 Tyrosine kinase-IN-1 Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively. Tyrosine kinase-IN-1 Chemical Structure
  41. GC10758 Tyrphostin 9 Tyrphostin 9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin 9 Chemical Structure
  42. GC39314 Tyrphostin AG1433 Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation. Tyrphostin AG1433 Chemical Structure
  43. GC15022 Vandetanib (ZD6474) Vandetanib (ZD6474) (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib (ZD6474) also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM). Vandetanib (ZD6474) Chemical Structure
  44. GC11876 Vandetanib hydrochloride A multi-kinase inhibitor Vandetanib hydrochloride Chemical Structure
  45. GC37886 Vandetanib trifluoroacetate Vandetanib trifluoroacetate (D6474 trifluoroacetate) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib trifluoroacetate also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM). Vandetanib trifluoroacetate Chemical Structure
  46. GC70111 Vanucizumab

    Vanucizumab is a novel bispecific IgG1 monoclonal antibody that can simultaneously block the interaction of VEGF-A and angiopoietin-2 (Ang-2) with their receptors. Vanucizumab has anti-angiogenic and anticancer effects.

     Vanucizumab Chemical Structure
  47. GC14464 Vatalanib A potent and selective VEGF receptor inhibitor Vatalanib Chemical Structure
  48. GC17955 Vatalanib (PTK787) 2HCl Vatalanib (PTK787) 2HCl (PTK787 dihydrochloride) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM. Vatalanib (PTK787) 2HCl Chemical Structure
  49. GC50233 Vatalanib succinate Potent VEGFR inhibitor; also aromatase inhibitor Vatalanib succinate Chemical Structure
  50. GC16062 VEGFR Tyrosine Kinase Inhibitor II VEGFR Tyrosine Kinase Inhibitor II (compound 3) is a potent angiogenesis inhibitor with IC50s of 0.02, 0.18, 0.24 7.3, and 7 μM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively. VEGFR Tyrosine Kinase Inhibitor II Chemical Structure
  51. GC66043 VEGFR-2-IN-29 VEGFR-2-IN-29 (Compound 5) is a VEGFR-2 inhibitor with an IC50 of 16.5 nM. VEGFR-2-IN-29 Chemical Structure
  52. GC61600 VEGFR-2-IN-6 VEGFR-2-IN-6 (example 64) is a VEGFR2 inhibitor (angiogenesis modulator), which is extracted from patent WO 02/059110. VEGFR-2-IN-6 Chemical Structure
  53. GC64205 VEGFR-3-IN-1 VEGFR-3-IN-1 is a potent and selective VEGFR3 inhibitor with an IC50 of 110.4 nM. VEGFR-3-IN-1 significantly inhibits proliferation and migration of VEGF-C-induced human dermal lymphatic endothelial cells (HDLEC), MDA-MB-231, and MDA-MB-436 cells by inactivating the VEGFR3 signaling pathway, and also effectively inhibits breast cancer growth. VEGFR-3-IN-1 Chemical Structure
  54. GC38380 Vorolanib Vorolanib (CM082) is an orally active, potent multikinase VEGFR/PDGFR inhibitor. Vorolanib Chemical Structure
  55. GC26063 WAY-340935 WAY-340935 (VEGFR2-IN-2) can inhibit the function of VEGFR2 and the anti-proliferative activity against the H460 cell line is produced partly by interaction of VEGFR protein. WAY-340935 Chemical Structure
  56. GC16000 WHI-P180 EGFR/Janus Kinase 3 inhibitor WHI-P180 Chemical Structure
  57. GC37933 WHI-P180 hydrochloride WHI-P180 (Janex 3) is a multi-kinase inhibitor; inhibits RET, KDR and EGFR with IC50s of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 hydrochloride Chemical Structure
  58. GC10195 Z-Guggulsterone

    Z-Guggulsterone suppresses angiogenesis in vitro and in vivo with IC50 values of 1740, 1000, 220 and > 50000 nM for glucocorticoid, mineralocorticoid, androgen and farnesoid X receptors .

     Z-Guggulsterone Chemical Structure
  59. GC33171 ZD-4190 ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer. ZD-4190 Chemical Structure
  60. GC31816 ZK-261991 ZK-261991 is an orally active VEGFR tyrosine kinase inhibitor with an IC50 of 5 nM for VEGFR2. ZK-261991 Chemical Structure
  61. GC12185 ZM 306416 VEGFR (Flt and KDR) inhibitor ZM 306416 Chemical Structure
  62. GC50028 ZM 306416 hydrochloride Inhibitor of VEGF receptor tyrosine kinase ZM 306416 hydrochloride Chemical Structure
  63. GC11555 ZM 323881 HCl ZM 323881 HCl is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. ZM 323881 HCl Chemical Structure
  64. GC12656 ZM323881 A potent and selective VEGFR2 inhibitor ZM323881 Chemical Structure

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