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Ubiquitination/ Proteasome

Products for  Ubiquitination/ Proteasome

  1. Cat.No. Product Name Information
  2. GC13892 C527 Inhibitor of USP1/USF1 complex C527  Chemical Structure
  3. GC17912 C598-0466

    USP7 inhibitor

    C598-0466  Chemical Structure
  4. GC45616 C6 Urea Ceramide An inhibitor of neutral ceramidase C6 Urea Ceramide  Chemical Structure
  5. GC12733 C646 C646, a potent and selective p300/CBP histone acetyltransferase inhibitor (Ki 400 nM), has been shown to have pleiotropic activity, including neuroprotective, anti-cancer and anti-epithelial-mesenchymal transition (anti-EMT) effects.. C646  Chemical Structure
  6. GC43105 C8 Ceramide (d18:1.8:0) C8 Ceramide (d18:1.8:0) (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8 Ceramide (d18:1.8:0)  Chemical Structure
  7. GC33218 CA-5f A potent late-stage macroautophagy/autophagy inhibitor CA-5f  Chemical Structure
  8. GC62881 CA77.1 CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1  Chemical Structure
  9. GC11765 Cabazitaxel Microtubule associated inhibitor Cabazitaxel  Chemical Structure
  10. GC65575 Cabazitaxel-d6 Cabazitaxel-d6 (XRP6258-d6) is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel-d6  Chemical Structure
  11. GC10441 Cabergoline potent dopamine receptor agonist Cabergoline  Chemical Structure
  12. GC13396 CAL-101 (Idelalisib, GS-1101) A selective PI3K p110δ inhibitor CAL-101 (Idelalisib, GS-1101)  Chemical Structure
  13. GC60668 Calcimycin hemimagnesium Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium  Chemical Structure
  14. GC30990 Calcineurin substrate Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. Calcineurin substrate  Chemical Structure
  15. GC38629 Calcineurin substrate (TFA) Calcineurin substrate (TFA)  Chemical Structure
  16. GC14326 Calmidazolium chloride

    Calmodulin antagonist

    Calmidazolium chloride  Chemical Structure
  17. GC31170 Calmodulin-Dependent Protein Kinase II 290-309 Calmodulin-Dependent Protein Kinase II 290-309 is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Calmodulin-Dependent Protein Kinase II 290-309  Chemical Structure
  18. GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Calmodulin-Dependent Protein Kinase II(290-309) acetate  Chemical Structure
  19. GC12527 Calpain Inhibitor I, ALLN A non-selective cysteine protease inhibitor Calpain Inhibitor I, ALLN  Chemical Structure
  20. GC40694 Calpain Inhibitor II Calpain Inhibitor II (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. Calpain Inhibitor II  Chemical Structure
  21. GC67908 Calpain-2-IN-1 Calpain-2-IN-1  Chemical Structure
  22. GC10342 Calpeptin A calpain inhibitor Calpeptin  Chemical Structure
  23. GC35601 CaMKII-IN-1 CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC. CaMKII-IN-1  Chemical Structure
  24. GC14065 Capsaicin A terpene alkaloid with diverse biological activities Capsaicin  Chemical Structure
  25. GC32815 Capzimin Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor. Capzimin  Chemical Structure
  26. GC17340 Carbamazepine Inhibitor of neuronal voltage-gated Na+ channels Carbamazepine  Chemical Structure
  27. GC11207 Carboplatin

    Antitumor agent that forms platinum-DNA adducts.

    Carboplatin  Chemical Structure
  28. GC15089 Carfilzomib (PR-171) A proteasome inhibitor Carfilzomib (PR-171)  Chemical Structure
  29. GC47042 Carfilzomib-d8 An internal standard for the quantification of carfilzomib Carfilzomib-d8  Chemical Structure
  30. GC17341 Carprofen COX inhibitor Carprofen  Chemical Structure
  31. GC14769 Carvedilol Potent β-adrenoceptor and α1-adrenoceptor antagonist Carvedilol  Chemical Structure
  32. GC35613 Carvedilol phosphate hemihydrate Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker. Carvedilol phosphate hemihydrate  Chemical Structure
  33. GC64003 Carvedilol-d4 Carvedilol-d4  Chemical Structure
  34. GC43189 CAY10681 Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer. CAY10681  Chemical Structure
  35. GC47065 CAY10773 A derivative of sorafenib CAY10773  Chemical Structure
  36. GC16351 CB-5083

    p97 inhibitor

    CB-5083  Chemical Structure
  37. GC20117 CB-5339

    CB-5339 is a second generation, potent and selective, orally bioavailable, ATP-competitive, small molecule inhibitor of valosin containing protein (VCP)/p97 [1,2].

    CB-5339  Chemical Structure
  38. GC15227 CB-839 CB-839 (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. CB-839 selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. CB-839 inudces autophagy and has antitumor activity. CB-839  Chemical Structure
  39. GC33006 CCT020312 CCT020312 is a selective EIF2AK3/PERK activator. CCT020312  Chemical Structure
  40. GC15864 CCT128930 AKT inhibitor CCT128930  Chemical Structure
  41. GC11464 CD 437 RARγ-selective agonist,potent and cell-permeable CD 437  Chemical Structure
  42. GC61865 Cearoin Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK. Cearoin  Chemical Structure
  43. GC16421 Cediranib (AZD217) Cediranib (AZD217) (AZD2171) is a highly potent, orally available VEGFR tyrosine kinase inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively. Cediranib (AZD217)  Chemical Structure
  44. GC33004 Cediranib maleate (AZD-2171 maleate) Cediranib maleate (AZD-2171 maleate) (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively. Cediranib maleate (AZD-2171 maleate)  Chemical Structure
  45. GC15083 Celastrol A triterpenoid antioxidant Celastrol  Chemical Structure
  46. GC12272 CEP-18770 An inhibitor of chymotrypsin-like proteasome activity CEP-18770  Chemical Structure
  47. GN10113 Cepharanthine Cepharanthine  Chemical Structure
  48. GC60688 Cereblon modulator 1 Cereblon modulator 1 (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Cereblon modulator 1  Chemical Structure
  49. GC35667 CFTR corrector 1 CFTR corrector 1 (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). CFTR corrector 1  Chemical Structure
  50. GC34532 CFTR corrector 2 CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933. CFTR corrector 2  Chemical Structure
  51. GC14421 CFTRinh-172 CFTR inhibitor, highly potent and selective CFTRinh-172  Chemical Structure
  52. GC35668 CG-200745 CG-200745 (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG-200745 inhibits deacetylation of histone H3 and tubulin. CG-200745 induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. CG-200745 enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil (5-FU; ). CG-200745 induces apoptosis and has anti-tumour effects. CG-200745  Chemical Structure
  53. GC13365 CGI-1746 A potent, selective BTK inhibitor CGI-1746  Chemical Structure
  54. GN10463 Chelerythrine Chelerythrine  Chemical Structure
  55. GC13065 Chelerythrine Chloride Potent inhibitor of PKC and Bcl-xL Chelerythrine Chloride  Chemical Structure
  56. GC17985 Chenodeoxycholic Acid nuclear receptors(FXR) activator Chenodeoxycholic Acid  Chemical Structure
  57. GC48595 Chenodeoxycholic Acid MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Chenodeoxycholic Acid MaxSpec® Standard  Chemical Structure
  58. GC15642 CHIR 99021 trihydrochloride Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR 99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR 99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR 99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR 99021 trihydrochloride induces autophagy. CHIR 99021 trihydrochloride  Chemical Structure
  59. GC16702 CHIR-99021 (CT99021)

    A selective GSK3 inhibitor

    CHIR-99021 (CT99021)  Chemical Structure
  60. GC32942 CHIR-99021 monohydrochloride (CT99021 monohydrochloride) CHIR-99021 monohydrochloride (CT99021 monohydrochloride)  Chemical Structure
  61. GN10518 Chitosamine hydrochloride Chitosamine hydrochloride  Chemical Structure
  62. GC60700 Chloroquine D5 Chloroquine D5 is deuterium labeled Chloroquine. Chloroquine D5  Chemical Structure
  63. GC10295 Chloroquine diphosphate Chloroquine diphosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine diphosphate  Chemical Structure
  64. GC45885 Chloroquine-d5 (phosphate) An internal standard for the quantification of chloroquine Chloroquine-d5 (phosphate)  Chemical Structure
  65. GC14216 Chlorpromazine HCl

    dopamine receptor antagonist

    Chlorpromazine HCl  Chemical Structure
  66. GC43265 Chromomycin A2 Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. Chromomycin A2  Chemical Structure
  67. GC10132 Ciclopirox broad-spectrum antifungal agent Ciclopirox  Chemical Structure
  68. GC13559 Cilengitide Integrin inhibitor for αvβ3 and αvβ5 Cilengitide  Chemical Structure
  69. GC61520 Cilengitide TFA Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively. Cilengitide TFA  Chemical Structure
  70. GC18212 Cilofexor Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay). Cilofexor  Chemical Structure
  71. GC15890 Cilostazol A PDE3A inhibitor Cilostazol  Chemical Structure
  72. GN10189 Cinobufagin Cinobufagin  Chemical Structure
  73. GC12226 Cisatracurium Besylate Neuromuscular-blocking drug Cisatracurium Besylate  Chemical Structure
  74. GC14035 Citalopram hydrobromide 5-HT uptake inhibitor Citalopram hydrobromide  Chemical Structure
  75. GC16754 Clarithromycin A macrolide antibiotic Clarithromycin  Chemical Structure
  76. GC16581 Clasto-Lactacystin β-lactone A selective inhibitor of the 20S proteasome Clasto-Lactacystin β-lactone  Chemical Structure
  77. GC14892 Clemastine Fumarate Selective histamine H1 receptor antagonist Clemastine Fumarate  Chemical Structure
  78. GC64524 Clematichinenoside AR Clematichinenoside AR is a major active ingredient that could be extracted from the traditional Chinese herb Clematis chinensis and has potent pharmacological effects on various diseases, including atherosclerosis (AS). Clematichinenoside AR  Chemical Structure
  79. GC15810 Clinofibrate HMGCR inhibitor Clinofibrate  Chemical Structure
  80. GC32078 Clioquinol (Iodochlorhydroxyquin) Clioquinol (Iodochlorhydroxyquin) (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol (Iodochlorhydroxyquin)  Chemical Structure
  81. GC15219 Clofarabine Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase Clofarabine  Chemical Structure
  82. GC16804 Clotrimazole antifungal compound Clotrimazole  Chemical Structure
  83. GC13261 Colchicine

    An inhibitor of microtubule polymerization

    Colchicine  Chemical Structure
  84. GC16332 Colistin Sulfate Cationic polypeptide antibiotic Colistin Sulfate  Chemical Structure
  85. GC17519 Concanamycin A

    V-type (vacuolar) H+-ATPase inhibitor

    Concanamycin A  Chemical Structure
  86. GN10810 Cordycepin Cordycepin  Chemical Structure
  87. GN10015 Corosolic Acid Corosolic Acid  Chemical Structure
  88. GC32959 Corynoxine An indole alkaloid Corynoxine  Chemical Structure
  89. GC52477 Corynoxine (hydrochloride) An indole alkaloid Corynoxine (hydrochloride)  Chemical Structure
  90. GC32826 Corynoxine B Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer. Corynoxine B  Chemical Structure
  91. GC14906 Crenolanib (CP-868596) Crenolanib (CP-868596) is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with Kds of 0.74 nM and 2.1 nM/3.2 nM, respectively. Crenolanib (CP-868596)  Chemical Structure
  92. GC30360 Cresol (Cresol mixture of isomers) Cresol (Cresol mixture of isomers)  Chemical Structure
  93. GC12616 Crizotinib hydrochloride

    inhibitor of the c-Met kinase and the NPM-ALK

    Crizotinib hydrochloride  Chemical Structure
  94. GN10501 Cryptotanshinone Cryptotanshinone  Chemical Structure
  95. GN10535 Cucurbitacin B Cucurbitacin B  Chemical Structure
  96. GN10526 Cucurbitacin E Cucurbitacin E  Chemical Structure
  97. GC14787 Curcumin A yellow pigment with diverse biological activities Curcumin  Chemical Structure
  98. GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS. Curcumin-d6  Chemical Structure
  99. GC14495 CX 546 AMPA receptor potentiator CX 546  Chemical Structure
  100. GC13037 CX-4945 (Silmitasertib) CX-4945 (Silmitasertib) (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. CX-4945 (Silmitasertib)  Chemical Structure
  101. GC11325 CX-4945 sodium salt CX-4945 sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. CX-4945 sodium salt  Chemical Structure

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