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Ubiquitination/ Proteasome

Products for  Ubiquitination/ Proteasome

  1. Cat.No. Product Name Information
  2. GC17795 Cyclocytidine HCl Ancitabine (hydrochloride) is an important antileukemia drugs. Cyclocytidine HCl  Chemical Structure
  3. GC38419 Cyclovirobuxine D An alkaloid with diverse biological activities Cyclovirobuxine D  Chemical Structure
  4. GC43354 Cysmethynil Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. Cysmethynil  Chemical Structure
  5. GC33779 Cysteamine (β-Mercaptoethylamine) Cysteamine (β-Mercaptoethylamine)  Chemical Structure
  6. GC13502 Cysteamine HCl Cysteamine HCl (2-Aminoethanethiol hydrochloride) is an orally active agent for the treatment of nephropathic cystinosis and an antioxidant. Cysteamine HCl  Chemical Structure
  7. GC17050 CYT387 A potent inhibitor of JAK1 and JAK2 CYT387  Chemical Structure
  8. GC16468 CYT387 sulfate salt A potent inhibitor of JAK1 and JAK2 CYT387 sulfate salt  Chemical Structure
  9. GC13070 Cytarabine Cytotoxic agent, blocks DNA synthesis Cytarabine  Chemical Structure
  10. GC14961 Cytarabine hydrochloride DNA synthsis inhibitor Cytarabine hydrochloride  Chemical Structure
  11. GC43359 Cytochalasin E The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. Cytochalasin E  Chemical Structure
  12. GC47271 D-Pyrohomoglutamic Acid A building block D-Pyrohomoglutamic Acid  Chemical Structure
  13. GC40792 D-threo Sphinganine (d18:0) D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0). D-threo Sphinganine (d18:0)  Chemical Structure
  14. GC13202 D4476 Inhibitor of CK1 and ALK5 D4476  Chemical Structure
  15. GN10318 Danshensu Danshensu  Chemical Structure
  16. GC34010 Danshensu (Dan shen suan A) Danshensu (Dan shen suan A)  Chemical Structure
  17. GC30072 Dansylcadaverine (Monodansyl cadaverine) Dansylcadaverine (Monodansyl cadaverine) (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine (Monodansyl cadaverine)  Chemical Structure
  18. GC30056 Danthron (Dantron) Danthron (Dantron) is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron (Dantron) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron (Dantron)  Chemical Structure
  19. GC30054 Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate) Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate) is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate)  Chemical Structure
  20. GC15217 Danusertib (PHA-739358) A pan-Aurora kinase and Abl inhibitor Danusertib (PHA-739358)  Chemical Structure
  21. GN10336 Daphnetin Daphnetin  Chemical Structure
  22. GC12942 DAPT (GSI-IX)

    Inhibitor of γ-secretase

    DAPT (GSI-IX)  Chemical Structure
  23. GC15568 Dasatinib (BMS-354825) An inhibitor of Abl and Src Dasatinib (BMS-354825)  Chemical Structure
  24. GC35812 Dasatinib hydrochloride A potent and dual AblWT/Src inhibitor Dasatinib hydrochloride  Chemical Structure
  25. GC12828 Daunorubicin

    DNA topoisomerase II inhibitor

    Daunorubicin  Chemical Structure
  26. GC10354 Daunorubicin HCl Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin HCl  Chemical Structure
  27. GC33003 Daurisoline ((R,R)-Daurisoline) Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor and also an autophagy blocker. Daurisoline ((R,R)-Daurisoline)  Chemical Structure
  28. GC64607 Dazcapistat Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively (patent WO2018064119A1, compound 405). Dazcapistat  Chemical Structure
  29. GC10824 DBeQ P97 ATPase inhibitor DBeQ  Chemical Structure
  30. GC65191 DC-LC3in-D5 DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5  Chemical Structure
  31. GC19485 DC661

    A potent PPT1 inhibitor

    DC661   Chemical Structure
  32. GC35820 DDD107498 succinate DDD107498 succinate (DDD-498 succinate) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. DDD107498 succinate  Chemical Structure
  33. GC13554 Deferoxamine mesylate

    Deferoxamine mesylate is a drug that chelates iron by forming a stable complex that prevents the iron from entering into further chemical reactions, and is used for the treatment of chronic iron overload in patients with transfusion-dependent anemias.

    Deferoxamine mesylate  Chemical Structure
  34. GC15484 Deguelin A potent antiproliferative rotenoid compound Deguelin  Chemical Structure
  35. GC35832 Dehydrocorydaline chloride An alkaloid with diverse biological activities Dehydrocorydaline chloride  Chemical Structure
  36. GC38528 Dehydropachymic acid Dehydropachymic acid is one of the major triterpenes isolated from Poria cocos. Dehydropachymic acid  Chemical Structure
  37. GN10529 Demethoxycurcumin Demethoxycurcumin  Chemical Structure
  38. GC38564 Deoxypodophyllotoxin Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from rhizomes of Sinopodophullumhexandrum (Berberidaceae). Deoxypodophyllotoxin  Chemical Structure
  39. GC39372 Desethyl chloroquine diphosphate Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Desethyl chloroquine diphosphate  Chemical Structure
  40. GC47193 Desethyl Hydroxychloroquine-d4 An internal standard for the quantification of desethyl hydroxychloroquine Desethyl Hydroxychloroquine-d4  Chemical Structure
  41. GC47194 Desethylchloroquine An active metabolite of chloroquine Desethylchloroquine  Chemical Structure
  42. GC47195 Desethylchloroquine-d4 An internal standard for the quantification of desethylchloroquine Desethylchloroquine-d4  Chemical Structure
  43. GC64136 Desmethyl Naproxen-d3 Desmethyl Naproxen-d3 is deuterium labeled Desmethyl Naproxen. Desmethyl Naproxen-d3  Chemical Structure
  44. GC40775 Dexamethasone

    Dexamethasone, as one member of the glucocorticoid family, can protect against arthritis-related changes in cartilage structure and function, including matrix loss, inflammation and cartilage viability.

    Dexamethasone  Chemical Structure
  45. GC14667 Dexamethasone (DHAP) Glucocorticoidan;anti-inflammatory Dexamethasone (DHAP)  Chemical Structure
  46. GC11237 Dexamethasone acetate

    IL Receptor modulator

    Dexamethasone acetate  Chemical Structure
  47. GC10750 Dexmedetomidine HCl Dexmedetomidine HCl ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine HCl  Chemical Structure
  48. GC11598 Diazoxide

    positive allosteric modulator of the AMPA and kainate receptors

    Diazoxide  Chemical Structure
  49. GC15578 Dienogest Orally active synthetic progesterone Dienogest  Chemical Structure
  50. GN10056 Dihydroartemisinin Dihydroartemisinin  Chemical Structure
  51. GC16747 Dihydroeponemycin Dihydroeponemycin  Chemical Structure
  52. GN10583 Dihydromyricetin Dihydromyricetin  Chemical Structure
  53. GC31697 Dilmapimod (SB-681323) Dilmapimod (SB-681323) (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease. Dilmapimod (SB-681323)  Chemical Structure
  54. GC49016 Dimethyl 2-ketoglutarate An esterified form of α-ketoglutarate Dimethyl 2-ketoglutarate  Chemical Structure
  55. GN10284 Dioscin Dioscin  Chemical Structure
  56. GC38408 Diosgenin glucoside Diosgenin glucoside  Chemical Structure
  57. GC15212 Divalproex Sodium Valproic acid (VPA) sodium (2:1) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Divalproex Sodium  Chemical Structure
  58. GC14298 DMH-1 Selective BMP ALK2 receptor DMH-1  Chemical Structure
  59. GC16973 DMOG

    An HIF-PH inhibitor

    DMOG  Chemical Structure
  60. GC17243 Dorsomorphin (Compound C) Dorsomorphin (Compound C) (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (Compound C) (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin (Compound C) induces autophagy. Dorsomorphin (Compound C)  Chemical Structure
  61. GC12560 Dorsomorphin (Compound C) 2HCl Dorsomorphin (Compound C) 2HCl (BML-275 dihydrochloride; Compound C dihydrochloride) is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin (Compound C) 2HCl inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin (Compound C) 2HCl induces autophagy. Dorsomorphin (Compound C) 2HCl  Chemical Structure
  62. GC13443 Doxazosin Mesylate α1-adrenergic receptor antagonist Doxazosin Mesylate  Chemical Structure
  63. GC16994 Doxorubicin Doxorubicin(DOX), also known as adriamycin, is a compound of the anthracycline class that has the broadest spectrum of activity[1]. Doxorubicin  Chemical Structure
  64. GC17567 Doxorubicin (Adriamycin) HCl Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin (Adriamycin) HCl  Chemical Structure
  65. GC16073 Dronedarone An antiarrhythmic agent Dronedarone  Chemical Structure
  66. GC12234 Dronedarone HCl Dronedarone HCl is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents. Dronedarone HCl  Chemical Structure
  67. GC17125 DUBs-IN-2 DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8. DUBs-IN-2  Chemical Structure
  68. GC10356 DUBs-IN-3 DUBs-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8. DUBs-IN-3  Chemical Structure
  69. GC10395 Dynasore

    Dynasore, as a GTPase inhibitor, can rapidly and reversibly inhibit dynamin activity, which prevents endocytosis.

    Dynasore  Chemical Structure
  70. GC13787 E 64d

    A protease inhibitor

    E 64d  Chemical Structure
  71. GC13418 E-64 A fungal metabolite with diverse biological activities E-64  Chemical Structure
  72. GC39305 EACC EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC  Chemical Structure
  73. GC10331 Ebselen A peroxynitrite scavenger Ebselen  Chemical Structure
  74. GN10564 Ecdysterone Ecdysterone  Chemical Structure
  75. GC12389 Efavirenz Reverse transcriptase inhibitor Efavirenz  Chemical Structure
  76. GC35969 eIF4A3-IN-1 eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD. eIF4A3-IN-1  Chemical Structure
  77. GC65540 eIF4A3-IN-2 eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM. eIF4A3-IN-2  Chemical Structure
  78. GC12846 Elaiophylin Macrodiolide antibiotic Elaiophylin  Chemical Structure
  79. GC10466 EMD-1214063

    EMD-1214063 (Tepotinib, MSC2156119J) is a novel potent and highly selective reversible, ATP-competitive small molecule c-Met inhibitor .

    EMD-1214063  Chemical Structure
  80. GC43599 Emetine (hydrochloride) An anti-protozoal drug used for intestinal and tissue amoebiasis Emetine (hydrochloride)  Chemical Structure
  81. GC32048 Emetine dihydrochloride hydrate

    An alkaloid with diverse biological activities

    Emetine dihydrochloride hydrate  Chemical Structure
  82. GC16044 Emodin Natural CK2 inhibitor and ER agonist Emodin  Chemical Structure
  83. GC49124 EN219 EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination. EN219  Chemical Structure
  84. GC35982 EN6 An activator of autophagy EN6  Chemical Structure
  85. GC15493 Enalaprilat Dihydrate angiotensin-converting enzyme (ACE) inhibitor Enalaprilat Dihydrate  Chemical Structure
  86. GC11625 Entinostat (MS-275,SNDX-275) A histone deacetylase inhibitor Entinostat (MS-275,SNDX-275)  Chemical Structure
  87. GC14476 Entrectinib Orally active inhibitor of ALK kinase Entrectinib  Chemical Structure
  88. GC11499 Enzastaurin (LY317615) Enzastaurin (LY317615) (LY317615) is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε. Enzastaurin (LY317615)  Chemical Structure
  89. GC35998 Episilvestrol Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol  Chemical Structure
  90. GC12494 Epoxomicin A highly selective proteasome inhibitor Epoxomicin  Chemical Structure
  91. GC10627 Erlotinib An EGFR tyrosine kinase inhibitor Erlotinib  Chemical Structure
  92. GC36003 Erlotinib mesylate EGFR inhibitor Erlotinib mesylate  Chemical Structure
  93. GC47303 Erlotinib-d6 (hydrochloride) An internal standard for the quantification of erlotinib Erlotinib-d6 (hydrochloride)  Chemical Structure
  94. GC10326 Erythromycin Ethylsuccinate Macrolide antibiotic Erythromycin Ethylsuccinate  Chemical Structure
  95. GC14968 Esmolol HCl Esmolol HCl is a beta adrenergic receptor blocker. Esmolol HCl  Chemical Structure
  96. GC13022 Esomeprazole Magnesium trihydrate An H+/K+-ATPase inhibitor Esomeprazole Magnesium trihydrate  Chemical Structure
  97. GC61669 Ethyl 3,4-dihydroxybenzoate Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate  Chemical Structure
  98. GC15617 Etoposide

    Topo II inhibitor

    Etoposide  Chemical Structure
  99. GC60826 Etoposide phosphate Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor?to prevent re-ligation of DNA strands. Etoposide phosphate  Chemical Structure
  100. GN10511 Eupatilin Eupatilin  Chemical Structure
  101. GC13601 Everolimus (RAD001) A rapamycin derivative Everolimus (RAD001)  Chemical Structure

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