Ubiquitination/ Proteasome
- Autophagy(1374)
- DUB(28)
- E1 Activating(1)
- E2 conjugating(1)
- E2 Ligases(0)
- E3 Ligase(8)
- Proteasome(123)
- p97(12)
- Mitophagy(104)
- ULK(10)
Products for Ubiquitination/ Proteasome
- Cat.No. Product Name Information
- GC15605 Ezetimibe Cholesterol transport inhibitor
- GC60159 Ezetimibe ketone Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe.
- GC36023 FAAH inhibitor 1 FAAH inhibitor 1 (Benzothiazole analog 3) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 18±8 nM.
- GC30751 FAAH-IN-1 FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.
- GC30366 FAAH-IN-2 FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent FAAH(fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2.
- GC62203 Falcarindiol Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells.
- GC38437 Fangchinoline An alkaloid with diverse biological activities
- GC13869 Fasudil Calcium antagonist
- GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil (HA-1077) HCl is also a potent Ca2+ channel antagonist and vasodilator.
- GC17173 Felodipine Selective L-type Ca2+ channel blocker
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GC12250
Fenofibrate
PPARα agonist
- GC17143 Fenretinide A synthetic retinoic acid derivative
- GC40484 Ferulic Acid methyl ester Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F.
- GC10755 Fexaramine farnesoid X receptor agonist
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GC13620
FIPI
phosholipase D (PLD) inhibitor
- GC15609 FK 866 hydrochloride NMPRTase inhibitor
- GC31563 FK-448 Free base FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.
- GC14308 FK866 (APO866) Inhibitor of nicotinamide phosphoribosyltransferase
- GC16063 Flavopiridol An inhibitor of cyclin-dependent kinases
- GC16425 Flavopiridol hydrochloride CDK inhibitor, potent and selective
- GC33848 Fludrocortisone acetate (9α-Fludrocortisone acetate) Fludrocortisone acetate (9α-Fludrocortisone acetate) (9α-Fludrocortisone acetate (9α-Fludrocortisone acetate)) is a synthetic mineralocorticoid, used to control the amount of sodium and fluids in your body.
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GC33715
Fluoxetine (LY-110140)
Fluoxetine (LY-110140) is an orally active selective serotonin reuptake inhibitor (SSRI). Fluoxetine is a potent inhibitor of the saturated [3H]-5-HT uptake process in rat and human platelets, with IC50 values of 0.10 and 0.05 μM, respectively.
- GC11709 Fluoxetine HCl Serotonin reuptake inhibitor,selective
- GC10064 Flurizan A COX-inactive enantiomer of flurbiprofen
- GC13535 Fluvastatin An HMG-CoA reductase inhibitor
- GC36061 Fluvastatin D6 sodium Fluvastatin D6 sodium (XU 62-320 D6) is deuterium labeled Fluvastatin sodium.
- GC15541 Fluvastatin Sodium An HMG-CoA reductase inhibitor
- GC36063 FMK 9a FMK 9a is an autophagin-1 inhibitor with IC50 values of 80 and 73 μM in FRET and LRA assay.
-
GC11920
Forskolin
Forskolin is a potent adenylyl cyclase activator with IC50 of 41 nM for type I adenylyl cyclase.
- GC32411 FR 167653 (FR 167653 sulfate) FR 167653 (FR 167653 sulfate) (FR 167653 (FR 167653 sulfate) sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity.
- GC31058 FR 167653 free base FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity.
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GC18000
Fulvestrant (ICI 182,780)
Fulvestrant is a selective estrogen receptor (ER) antagonist. It binds, blocks and degrades ER, then inhibits ER-mediated transcriptional activity with an IC50 of 9.4 nM.
- GC13711 Gabexate mesylate A serine protease inhibitor
- GN10137 Galangin
- GC12139 Gambogic Acid A xanthonoid with anticancer activity
- GN10109 Ganoderic Acid A
-
GC10359
GANT61
GANT61 was able to efficiently block GLI1 as well as GLI2-induced transcription, IC50 is 5 µM.
- GC32739 GCN2iB GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM.
- GC12021 GDC-0349 MTOR inhibitor
- GC10493 GDC-0449 (Vismodegib)
- GC10816 GDC-0941 A pan inhibitor of class I PI3K isoforms
- GC16154 GDC-0941 dimethanesulfonate A pan inhibitor of class I PI3K isoforms
- GC60868 Gefitinib D8 Gefitinib D8 (ZD1839 D8) is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells.
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GC16805
Gemcitabine
An inhibitor of DNA synthesis
- GC36130 Gemcitabine elaidate A prodrug form of gemcitabine
- GC14447 Gemcitabine HCl Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
- GN10116 Genipin
-
GC14102
Genistein
Genistein is an isoflavone belonging to the flavonoid group of compounds and is found in a number of plants.
- GN10782 Genistin
- GC31717 Ginkgetin A biflavonoid with diverse biological activities
- GC36136 Ginkgolide K Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway.
- GN10148 Ginsenoside F2
- GN10156 Ginsenoside Rb1
- GC32998 Ginsenoside Rh4
- GC33085 Glaucocalyxin B Glaucocalyxin B is an ent kaurane diterpenoid isolated from the Chinese traditional medicine Rabdosia japonica with anticancer and antitumor activity; decreases the growth of HL-60 cells with an IC50 of approximately 5.86 μM at 24 h.
- GC12356 Glibenclamide Insulin production modulator
- GC17255 Gliotoxin An immunosuppressive mycotoxin with diverse biological effects
- GC19169 GLPG1837 GLPG1837 is a potent and reversible CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
- GC36149 GLPG2451 GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM.
- GC30263 Glucosamine (D-Glucosamine) Glucosamine (D-Glucosamine) (D-Glucosamine (D-Glucosamine)) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement.
- GN10669 Glucosamine sulfate
- GC40911 Glycine-β-muricholic Acid Glycine-β-muricholic Acid, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders.
- GC47408 Glycochenodeoxycholic Acid-d4 A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
- GC36163 Glycycoumarin Glycycoumarin is a potent antispasmodic agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases.
- GC17804 GlyH-101 CFTR Inhibitor II
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GC60882
Glyphosate
An herbicide
- GC41308 GPP 78 Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase.
- GC10715 GSK 4112 Rev-Erbα agonist
- GC15072 GSK2126458 GSK2126458 (GSK2126458) is an orally active and highly selective inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively. GSK2126458 has anti-cancer activity.
- GC18049 GSK2578215A LRRK2 inhibitor
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GC17450
GSK2606414
A selective PERK inhibitor
- GC11068 GSK2656157 PERK inhibitor
- GC17534 GSK343 A selective, cell-permeable EZH2 inhibitor
- GC64213 GSK3494245 GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the β4 and β5 subunits (IC50=0.16 μM for WT L.
-
GC13696
GSK690693
GSK690693 is an ATP-competitive, low nanomolar inhibitor of Akt kinases with IC50 values of 2, 13, and 9 nM for Akt1, 2, and 3, respectively.
- GC17658 Guggulsterone Broad spectrum steroid receptor ligand
- GC60891 GW406108X GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK.
-
GC10975
GW4064
GW4064, as a synthetic FXR agonist, was used for treatment of cholestatic liver diseases, metabolic syndrome and alcoholic liver disease.
- GC15318 GW501516 A selective PPARδ-agonist with anti-obesity activity
- GC45719 Gymnemic Acid I A triterpene glycoside
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GC19396
H 89
A potent inhibitor of cyclic AMP-dependent protein kinase
- GC10074 H 89 2HCl H 89 2HCl is a potent and selective inhibitor of protein kinase A (PKA) with an IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase.
- GA10942 H-D-Gln-OH
- GC19188 HA15 HA15 is a molecule that targets specifically BiP/GRP78/HSPA5.
- GC12622 HBX 41108 Ubiquitin-specific protease (USP) 7 inhibitor
- GC14591 Hemin chloride Hemin chloride is an iron-containing porphyrin.
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GC10829
Heparin
injectable anticoagulant
- GC36215 Heparin Lithium salt Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII).
-
GC19766
Heparin sodium salt (MW 15kDa)
A polymer of Heparin with the molecular weight of 15kD
- GC17196 Hesperadin A multi-kinase inhibitor
- GN10613 Hesperidin
- GN10248 Hesperitin
- GC45639 Hexapeptide-11 (acetate) A synthetic hexapeptide
- GC16699 HMB-Val-Ser-Leu-VE inhibitor of the trypsin-like activity of the 20S proteasome
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GC63515
Hoechst 33342
The nucleic acid stain Hoechst 33342 (Ex/Em: 350/461 nm) is frequently utilized as a cell-permeable nuclear counterstain that emits a blue fluorescence upon binding to dsDNA.
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GC10939
Hoechst 33342 trihydrochloride
The nucleic acid stain Hoechst 33342 trihydrochloride (Ex/Em: 350/461 nm) is frequently utilized as a cell-permeable nuclear counterstain that emits a blue fluorescence upon binding to dsDNA.
- GN10664 Honokiol
- GC47436 HT-2 Toxin-13C22 An internal standard for the quantification of HT-2 toxin
- GC19569 Hydroquinone
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GC12544
Hydroxychloroquine Sulfate
Autophagy inhibitor