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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome

Products for  Ubiquitination/ Proteasome

  1. Cat.No. Product Name Information
  2. GC17865 Lomustine Antineoplastic drug Lomustine Chemical Structure
  3. GC10330 Lonafarnib A farnesyltransferase inhibitor with antitumor activity Lonafarnib Chemical Structure
  4. GC61003 Loperamide D6 hydrochloride Loperamide D6 hydrochloride (R-18553 D6 hydrochloride) is a deuterium labeled Loperamide hydrochloride. Loperamide D6 hydrochloride Chemical Structure
  5. GC36479 Loperamide hydrochloride Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist. Loperamide hydrochloride Chemical Structure
  6. GC13717 Losmapimod p38 MAPK inhibitor, orally active Losmapimod Chemical Structure
  7. GC11633 Lovastatin An inhibitor of HMG-CoA reductase Lovastatin Chemical Structure
  8. GC33126 Lucanthone Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1). Lucanthone Chemical Structure
  9. GC32152 Lumefantrine (Benflumetol) Lumefantrine (Benflumetol) is an antimalarial drug, used in combination with Artemether. Lumefantrine (Benflumetol) Chemical Structure
  10. GC64363 Lumefantrine-d9 Lumefantrine-d9 Chemical Structure
  11. GN10370 Luteolin Luteolin Chemical Structure
  12. GC65432 LV-320 LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC50 of 24.5??M and a Kd of 16??M. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. LV-320 Chemical Structure
  13. GC30884 LX2343 An inhibitor of BACE1 and PI3K LX2343 Chemical Structure
  14. GC64282 LXE408 LXE408 is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 Chemical Structure
  15. GC12363 LY2109761 TβRI/II kinase inhibitor LY2109761 Chemical Structure
  16. GC15094 LY2183240 A potent, competitive inhibitor of anandamide uptake LY2183240 Chemical Structure
  17. GC16835 LY2228820 LY2228820 (LY2228820 dimesylate) is a selective, ATP-competitive inhibitor of p38 MAPK α/β with IC50s of 5.3 and 3.2 nM, respectively. LY2228820 Chemical Structure
  18. GC19421 LY2562175

    LY2562175 is a potent and selective?FXR?agonist with an?EC50?of 193 nM

     LY2562175 Chemical Structure
  19. GC15741 LY2603618 LY2603618 (LY2603618) is a potent and selective inhibitor of Chk1 with an IC50 of 7 nM. LY2603618 Chemical Structure
  20. GC19232 LY2955303 LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM. LY2955303 Chemical Structure
  21. GC13980 LY3009120

    LY3009120 is a pan-RAF and RAF dimer inhibitor that inhibits all RAF isoforms and occupies both protomers in RAF dimers.

     LY3009120 Chemical Structure
  22. GC14371 LY3023414 LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. LY3023414 potently inhibits mTORC1/2 at low nanomolar concentrations. LY3023414 Chemical Structure
  23. GN10396 Lycorine chloride Lycorine chloride Chemical Structure
  24. GC19236 LYN-1604 LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) agonist with an EC50 of 18.94 nM. LYN-1604 Chemical Structure
  25. GC36517 LYN-1604 hydrochloride LYN-1604 hydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC). LYN-1604 hydrochloride Chemical Structure
  26. GC19237 Lys01 trihydrochloride Lys01 trihydrochloride (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. Lys01 trihydrochloride Chemical Structure
  27. GN10301 Magnolol Magnolol Chemical Structure
  28. GC40007 Malformin A Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. Malformin A Chemical Structure
  29. GC30676 MAPK13-IN-1 MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM. MAPK13-IN-1 Chemical Structure
  30. GC12376 Maprotiline HCl Maprotiline HCl is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant. Maprotiline HCl Chemical Structure
  31. GC17874 Matrine An alkaloid with diverse biological activities Matrine Chemical Structure
  32. GC10200 Mdivi 1

    A mitochondrial division inhibitor

     Mdivi 1 Chemical Structure
  33. GC11640 MDL 28170 A cell permeable, selective calpain inhibitor MDL 28170 Chemical Structure
  34. GC12385 MDV3100 (Enzalutamide)

    A non-steroidal androgen receptor antagonist

     MDV3100 (Enzalutamide) Chemical Structure
  35. GC13252 Meclizine 2HCl Histamine H1 receptor antagonist Meclizine 2HCl Chemical Structure
  36. GC15854 Mefloquine hydrochloride An antimalarial compound Mefloquine hydrochloride Chemical Structure
  37. GC11688 Megestrol Acetate Anti-estrogen agent Megestrol Acetate Chemical Structure
  38. GC34035 Meglutol (Dicrotalic acid) Meglutol (Dicrotalic acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol. Meglutol (Dicrotalic acid) Chemical Structure
  39. GC12843 MEK162 (ARRY-162, ARRY-438162) MEK162 (ARRY-162, ARRY-438162) (MEK162) is an oral and selective MEK1/2 inhibitor. MEK162 (ARRY-162, ARRY-438162) (MEK162) inhibits MEK with an IC50 of 12 nM. MEK162 (ARRY-162, ARRY-438162) Chemical Structure
  40. GC15618 Melatonin Melatonin receptors agonist Melatonin Chemical Structure
  41. GC60241 Melatonin D5 An internal standard for the quantification of melatonin Melatonin D5 Chemical Structure
  42. GC11762 Meloxicam (Mobic) Meloxicam (Mobic) is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively. Meloxicam (Mobic) Chemical Structure
  43. GC40065 Meloxicam-d3 Meloxicam-d3 is intended for use as an internal standard for the quantification of meloxicam by GC- or LC-MS. Meloxicam-d3 Chemical Structure
  44. GC10198 Memantine hydrochloride NMDA receptor antagonist Memantine hydrochloride Chemical Structure
  45. GC15668 Meprednisone Glucocorticoid receptor (GR) agonist Meprednisone Chemical Structure
  46. GC13704 Mercaptopurine (6-MP) Mercaptopurine (6-MP) is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug. Mercaptopurine (6-MP) Chemical Structure
  47. GC61045 Metformin D6 hydrochloride An internal standard for the quantification of metformin Metformin D6 hydrochloride Chemical Structure
  48. GC17443 Metformin HCl Metformin HCl (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin HCl Chemical Structure
  49. GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram Methyl Diethyldithiocarbamate Chemical Structure
  50. GC15505 Methylprednisolone A synthetic glucocorticoid Methylprednisolone Chemical Structure
  51. GC30356 Metofenazate (Methophenazine) Metofenazate (Methophenazine) is a selective calmodulin inhibitor. Metofenazate (Methophenazine) Chemical Structure
  52. GC17411 Metyrapone 11-β hydroxylase (CYP11B1) inhibitor Metyrapone Chemical Structure
  53. GC11895 Mevastatin HMG-CoA reductase inhibitor Mevastatin Chemical Structure
  54. GC10178 MG-115 A potent, reversible proteasome inhibitor MG-115 Chemical Structure
  55. GC10383 MG-132

    A potent proteasome inhibitor

     MG-132 Chemical Structure
  56. GC15517 MG-262 A proteasome inhibitor with diverse biological activities MG-262 Chemical Structure
  57. GC13790 MHY1485

    MHY1485 is a potent activator of mTOR, which inhibits autophagy and the fusion between autophagosomes and lysosomes.

     MHY1485 Chemical Structure
  58. GC11637 Mifepristone Progesterone receptor antagonist Mifepristone Chemical Structure
  59. GC62564 Mito-LND Mito-LND (Mito-Lonidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS). Mito-LND inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species, and induces autophagic cell death in lung cancer cells. Mito-LND Chemical Structure
  60. GC16304 MK-2206 dihydrochloride

    An allosteric Akt inhibitor

     MK-2206 dihydrochloride Chemical Structure
  61. GC17162 MK-5108 (VX-689) A potent inhibitor of Aurora kinases MK-5108 (VX-689) Chemical Structure
  62. GC14059 ML 240 ATP-competitive inhibitor of p97 ATPase ML 240 Chemical Structure
  63. GC50067 ML 3403

    p38 inhibitor

     ML 3403 Chemical Structure
  64. GC17635 ML-323 USP1-UAF1 inhibitor ML-323 Chemical Structure
  65. GC11749 ML241 p97 ATPase inhibitor ML241 Chemical Structure
  66. GC13656 ML241 hydrochloride p97 ATPase inhibitor ML241 hydrochloride Chemical Structure
  67. GC32785 ML327 ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT). ML327 Chemical Structure
  68. GC17329 MLCK inhibitor peptide 18 Selective competitive inhibitor of myosin light chain kinase MLCK inhibitor peptide 18 Chemical Structure
  69. GC16146 MLN2238 A 20S proteasome inhibitor and an active metabolite of MLN9708 MLN2238 Chemical Structure
  70. GC12690 MLN8237 (Alisertib)

    An Aurora A kinase inhibitor

     MLN8237 (Alisertib) Chemical Structure
  71. GC13718 MLN9708 A prodrug form of MLN2238 MLN9708 Chemical Structure
  72. GC10048 MNS Inhibitor of Src/Syk tyrosine kinases MNS Chemical Structure
  73. GC13055 Mocetinostat (MGCD0103, MG0103) An orally available HDAC inhibitor Mocetinostat (MGCD0103, MG0103) Chemical Structure
  74. GC36646 Momelotinib Mesylate Momelotinib Mesylate (CYT387 Mesylate) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, appr 10-fold selectivity versus JAK3. Momelotinib Mesylate Chemical Structure
  75. GC31586 Monacolin J (Antibiotic MB 530A) Monacolin J (Antibiotic MB 530A) is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase. Monacolin J (Antibiotic MB 530A) Chemical Structure
  76. GC48676 Monascuspiloin A fungal metabolite with anticancer activity Monascuspiloin Chemical Structure
  77. GC11006 Montelukast Sodium Leukotriene receptor antagonist Montelukast Sodium Chemical Structure
  78. GC17136 MRT67307 A kinase inhibitor MRT67307 Chemical Structure
  79. GC25650 MRT67307 HCl MRT67307 is a potent and dual IKKε and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy. MRT67307 HCl Chemical Structure
  80. GC14086 MRT68921 A dual autophagy kinase ULK1/2 inhibitor MRT68921 Chemical Structure
  81. GC36654 MRT68921 dihydrochloride MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride Chemical Structure
  82. GC25651 MRT68921 HCl MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. MRT68921 HCl Chemical Structure
  83. GC60257 MSC1094308 MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively. MSC1094308 inhibits the D2 ATPase activity by binding to a drugable hotspot of p97. MSC1094308 can be used in study of cancer. MSC1094308 Chemical Structure
  84. GC65115 mTOR inhibitor-1 mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy. mTOR inhibitor-1 Chemical Structure
  85. GC62339 mTOR inhibitor-8 mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells. mTOR inhibitor-8 Chemical Structure
  86. GC65297 MW-150 MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 Chemical Structure
  87. GC34918 MW-150 dihydrochloride dihydrate MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 dihydrochloride dihydrate Chemical Structure
  88. GC34094 Mycro 3 Mycro 3 is a potent and selective inhibitor of Myc-associated factor X (MAX) dimerization. Mycro 3 also inhibit DNA binding of c-Myc. Mycro 3 could be used for the research of pancreatic cancer. Mycro 3 Chemical Structure
  89. GN10634 Myricetin Myricetin Chemical Structure
  90. GC47735 N-acetyl Desethylchloroquine-d4 An internal standard for the quantification of N-acetyl desethylchloroquine N-acetyl Desethylchloroquine-d4 Chemical Structure
  91. GC36671 N-Benzyllinolenamide N-Benzyllinolenamide is a natural macamide isolated from Lepidium meyenii, acts as an inhibitor of fatty acid amide hydrolase (FAAH) with an IC50 of 41.8 μM. N-Benzyllinolenamide Chemical Structure
  92. GC36703 N-Benzyloleamide N-Benzyloleamide is a maccamide isolated from Lepidium meyenii (Maca). N-Benzyloleamide Chemical Structure
  93. GC13063 N-Benzylpalmitamide inhibitor of fatty acid amide hydrolase (FAAH) N-Benzylpalmitamide Chemical Structure
  94. GC44346 N-Desethylamiodarone (hydrochloride) N-Desethylamiodarone (hydrochloride) (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. N-Desethylamiodarone (hydrochloride) Chemical Structure
  95. GC50234 N106 Activator of SUMO-activating enzyme, E1 ligase N106 Chemical Structure
  96. GC44290 NAADP (sodium salt)

    Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization.

     NAADP (sodium salt) Chemical Structure
  97. GC44291 NAB 2 NAB 2 is an inhibitor of α-synuclein-induced toxicity. NAB 2 Chemical Structure
  98. GC36690 Nampt-IN-3 Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death. Nampt-IN-3 Chemical Structure
  99. GC17975 Naproxen Sodium cyclooxygenase inhibitor Naproxen Sodium Chemical Structure
  100. GN10257 Naringin Naringin Chemical Structure
  101. GC11008 Necrostatin-1

    A RIP1 kinase inhibitor

     Necrostatin-1 Chemical Structure

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