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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome

Products for  Ubiquitination/ Proteasome

  1. Cat.No. Product Name Information
  2. GC13223 Aliskiren Hemifumarate

    CGP 60536, SPP 100

     renin inhibitor Aliskiren Hemifumarate Chemical Structure
  3. GN10407 Alisol A Alisol A Chemical Structure
  4. GC14749 ALLO-1 ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. ALLO-1 Chemical Structure
  5. GN10516 Aloeemodin

    3-Hydroxymethylchrysazine, NSC 38628, Rhabarberone

     Aloeemodin Chemical Structure
  6. GC14314 Aloperine An alkaloid Aloperine Chemical Structure
  7. GC13789 AM 114

    PS-IX; AM114

     AM 114 Chemical Structure
  8. GC13664 AM580

    CD336, NSC 608001, Ro 406055

     Selective RARα agonist AM580 Chemical Structure
  9. GC72896 AMDE-1 AMDE-1 is a potent autophagy inducer. AMDE-1 Chemical Structure
  10. GC35322 Amiodarone Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM. Amiodarone Chemical Structure
  11. GC11432 Amiodarone HCl Amiodarone HCl, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ~45 nM. Amiodarone HCl Chemical Structure
  12. GC63316 Ammonium chloride Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride Chemical Structure
  13. GC12326 Amsacrine Topoisomerase 2 inhibitor Amsacrine Chemical Structure
  14. GC11747 Amsacrine hydrochloride

    AMSA, m-AMSA, NSC 141549

     Topoisomerase 2 inhibitor Amsacrine hydrochloride Chemical Structure
  15. GN10718 Andrographolide Andrographolide Chemical Structure
  16. GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

    Androkinin, NSC 9898

    An androgenic steroid

     Androsterone (5α-Androstan-3α-ol-17-one) Chemical Structure
  17. GC91040 AP-1

    A PROTAC that drives ALK degradation

     AP-1 Chemical Structure
  18. GC14292 Apatinib Mesylate

    YN968D1

     Apatinib Mesylate blocks the downstream signal transduction of VEGF pathway to inhibit neovascularization. Apatinib Mesylate Chemical Structure
  19. GN10150 Apigenin

    Chamomile, Flavone, NSC 83244, Versulin

     Apigenin (API), or 4′,5,7-trihydroxyflavone, is a bioactive flavonoid present in many plants, known for its anti-inflammatory, antioxidant, and anticancer properties. Apigenin Chemical Structure
  20. GC16237 Apocynin

    Acetoguaiacone, Acetovanillone, NSC 2146, NSC 209524

     Selective NADPH-oxidase inhibitor Apocynin Chemical Structure
  21. GC65004 Apostatin-1

    Apt-1

     Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 Chemical Structure
  22. GC14590 AR-42 (OSU-HDAC42)

    HDAC inhibitor,novel and potent

     AR-42 (OSU-HDAC42) Chemical Structure
  23. GC19035 AR7 A retinoic acid receptor α (RARα) antagonist AR7 Chemical Structure
  24. GN10063 Arctigenin Arctigenin,a natural lignan compound,has demonstrated anticancer activities in cancer. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin Chemical Structure
  25. GC73863 ARI-3144 ARI-3144 is an excellent substrate for fibroblast activation protein (FAP). ARI-3144 Chemical Structure
  26. GC12784 Artemether (SM-224)

    (+)-Artemether, SM-224

     An antiparasitic compound Artemether (SM-224) Chemical Structure
  27. GC12474 AS-605240 Potent and selective PI 3-Kγ inhibitor AS-605240 Chemical Structure
  28. GC62309 AS1708727 AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively. AS1708727 Chemical Structure
  29. GC19040 AS1842856

    FOXO1 Inhibitor

     AS1842856 is a cell permeable inhibitor that inhibits Foxo1 transcriptional activity with IC50=33 nM. AS1842856 Chemical Structure
  30. GC74029 ASCT2-IN-1 ASCT2-IN-1 (compound 20k) is an ASCT2 inhibitor with IC50 values of 5.6 μM and 3.5 μM in cells A549 and HEK293, respectively. ASCT2-IN-1 Chemical Structure
  31. GC74030 ASCT2-IN-2 ASCT2-IN-2 (compound 25e) is an ASCT2 inhibitor with IC50 of 5.14 μM. ASCT2-IN-2 Chemical Structure
  32. GC40769 Asperphenamate

    Anabellamide, Auranamide, NSC 306231

     Asperphenamate is a fungal secondary metabolite originally isolated from A. Asperphenamate Chemical Structure
  33. GC15706 Aspirin (Acetylsalicylic acid)

    Acetylsalicylic Acid, NSC 27223, NSC 406186

     A non-selective, irreversible COX inhibitor Aspirin (Acetylsalicylic acid) Chemical Structure
  34. GC11106 AT-101 AT-101 Chemical Structure
  35. GC10638 AT9283 A broad spectrum kinase inhibitor AT9283 Chemical Structure
  36. GC73718 ATG12-ATG3 inhibitor 1 ATG12-ATG3 inhibitor 1 (compound 189) is a potent inhibitor of autophage. ATG12-ATG3 inhibitor 1 Chemical Structure
  37. GC68705 ATG7-IN-2

    ATG7-IN-2 (Compound 1) is an effective inhibitor of ATG7 with an IC50 value of 0.089 μM. ATG7-IN-2 can inhibit the autophagy marker LC3B.

     ATG7-IN-2 Chemical Structure
  38. GC35419 Atorvastatin

    Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.

     Atorvastatin Chemical Structure
  39. GC14038 Atorvastatin Calcium

    CI-981; Atorvastatin hemicalcium

     An HMG-CoA reductase inhibitor Atorvastatin Calcium Chemical Structure
  40. GC16526 Atropine

    Tropine

     MAChRs antagonist Atropine Chemical Structure
  41. GC63827 Atropine sulfate monohydrate Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect. Atropine sulfate monohydrate Chemical Structure
  42. GC71423 ATTECs Degrader 1 ATTECs Degrader 1 (Compound MT1) is an ATTECs compound. ATTECs Degrader 1 Chemical Structure
  43. GC62853 Aumitin Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin Chemical Structure
  44. GC70702 AUTAC1 AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTAC1 Chemical Structure
  45. GC70703 AUTAC2 AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 Chemical Structure
  46. GC74023 AUTAC2-2G AUTAC2-2G is a second-generation AUTAC with a 100-fold increase in activity. AUTAC2-2G Chemical Structure
  47. GC70444 AUTEN-67 AUTEN-67 (Autophagy enhancer-67) is an orally active autophagy enhancer and MTMR14 inhibitor. AUTEN-67 Chemical Structure
  48. GC46897 AUTEN-99

    Autophagy Enhancer-99

     AUTEN-99 (hydrobromide) is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14). AUTEN-99 Chemical Structure
  49. GC33683 Autocamtide 2 (Autocamtide II)

    Autocamtide II

     Autocamtide 2 (Autocamtide II) is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 (Autocamtide II) Chemical Structure
  50. GC34390 Autocamtide 2, amide Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays. Autocamtide 2, amide Chemical Structure
  51. GC35432 Autocamtide-2-related inhibitory peptide (TFA) Autocamtide-2-related inhibitory peptide (TFA) Chemical Structure
  52. GC50305 Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide Autocamtide-2-related inhibitory peptide, myristoylated Chemical Structure
  53. GC35433 Autogramin-1 Autogramin-1 potently inhibits autophagy induced by either starvation (IC50=0.17 μM) or mTORC1 inhibition (Rapamycin; IC50=0.44 μM). Autogramin-1 Chemical Structure
  54. GC35434 Autogramin-2 Autogramin-2 potently inhibits autophagy induced by either starvation (IC50=0.27 μM) or mTORC1 inhibition (Rapamycin; IC50=0.14 μM). Autogramin-2 Chemical Structure
  55. GC19453 Autophinib

    Autophinib is a potent autophagy inhibitor

     Autophinib Chemical Structure
  56. GC15295 AUY922 (NVP-AUY922)

    VER-52296, AUY-922, AUY 922, Luminespib

     AUY922 (NVP-AUY922) is a potent and selective inhibitor of HSP90, effectively inhibiting both HSP90α and HSP90β with similar IC50 values of 13nM and 21nM, respectively. AUY922 (NVP-AUY922) Chemical Structure
  57. GC11081 Avermectin B1

    Avermectin B1, Avermectin B1a (~80%) and Avermectin B1b (~20%) Mixture, MK-936, Rustomectin

     An insecticide and anthelmintic Avermectin B1 Chemical Structure
  58. GC19479 AZ304

    A dual inhibitor

     AZ304 Chemical Structure
  59. GC35445 Azathramycin Azathramycin (Azaerythromycin A) is an antibiotic and targets ribosome. Azathramycin Chemical Structure
  60. GC14189 AZD-3463

    ALK/IGF1R inhibitor

     ALK/IGF1R inhibitor AZD-3463 Chemical Structure
  61. GC12660 AZD1208

    AZD 1208;AZD-1208

     AZD1208 is a potent, highly selective, and orally available Pim kinase inhibitor, with IC50 values of 0.4, 5, and 1.9nM for PIM1, PIM2, and PIM3, respectively. AZD1208 Chemical Structure
  62. GC13029 AZD2014

    AZD 2014; AZD-2014

     AZD2014 (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes. AZD2014 Chemical Structure
  63. GC11752 AZD5363 AZD5363 (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively. AZD5363 Chemical Structure
  64. GC16851 AZD6482

    KIN-193

    PI3Kβ inhibitor,potent and selective

     AZD6482 Chemical Structure
  65. GC31924 AZD7624 AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 Chemical Structure
  66. GC16380 AZD8055

    CCG-168

    AZD8055 is a new ATP-competitive mTOR inhibitor with an IC50 of 0.8 nmol/L and a Ki of 1.3 nmol/L.

     AZD8055 Chemical Structure
  67. GC14507 Azithromycin

    CP 62,993

     Antibiotic by inhibiting protein synthesis Azithromycin Chemical Structure
  68. GC11304 Azithromycin Dihydrate Azithromycin Dihydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections. Azithromycin Dihydrate Chemical Structure
  69. GC35462 Bafetinib

    INNO-406

    Bcr-Abl/Lyn tyrosine kinase inhibitor

     Bafetinib Chemical Structure
  70. GC17597 Bafilomycin A1

    NSC 381866

    Bafilomycin A1, a macrolide antibiotic isolated from the Streptomyces species, is an inhibitor of vacuolar H ATPase (V-ATPase).

     Bafilomycin A1 Chemical Structure
  71. GN10018 Baicalin

    Baicalein 7-glucuronide

     Baicalin is a flavonoid glycoside and an allosteric carnitine palmitoyltransferase 1 (CPT1) activator. Baicalin Chemical Structure
  72. GN10590 Bakuchiol

    (S)-(+)-Bakuchiol

     Bakuchiol Chemical Structure
  73. GC30565 BAR502 A dual agonist of GP-BAR1 and FXR BAR502 Chemical Structure
  74. GC11572 Bardoxolone methyl

    Bardoxolone methyl, NSC 713200, RTA 402, TP155

     A synthetic triterpenoid with potent anticancer and antidiabetic activity Bardoxolone methyl Chemical Structure
  75. GC13035 Bay 11-7821

    BAY 11-7082

     Bay 11-7821(BAY 11-7082) is an inhibitor of IκBα phosphorylation and NF-κB, selectively and irreversibly inhibits TNF-α-induced IκB-α phosphorylation (IC50 value is approximately 10μM), and reduces the expression of NF-κB and adhesion molecules. Bay 11-7821 inhibits ubiquitin-specific proteases USP7 and USP21 with IC50 values of 0.19 and 0.96μM, respectively . Bay 11-7821 Chemical Structure
  76. GC18487 BC-1215 BC-1215 is an inhibitor of F-box protein 3 (FBXO3; IC50 = 0.9 μg/mL for Il-1β release). BC-1215 Chemical Structure
  77. GC72901 BC-23

    NSC 45382

     BC-23 (NSC 45382) is a proteasome inhibitor. BC-23 Chemical Structure
  78. GC62135 BC1618 BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618 Chemical Structure
  79. GC71374 Beclin1-ATG14L interaction inhibitor 1 Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. Beclin1-ATG14L interaction inhibitor 1 Chemical Structure
  80. GN10443 Berbamine Berbamine Chemical Structure
  81. GN10358 Berbamine hydrochloride Berbamine hydrochloride Chemical Structure
  82. GN10221 Berberine

    Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase.

     Berberine Chemical Structure
  83. GC35497 Berberine chloride hydrate Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties. Berberine chloride hydrate Chemical Structure
  84. GN10208 Berberine hydrochloride

    BBR, Umbellatine, NSC 163088, NSC 646666

     Berberine hydrochloride is a bioactive alkaloid of the isoquinoline class derived from the medicinal plant Coptis chinensis of the Ranunculaceae family, possessing a wide range of pharmacological functions with applications in cancer, inflammation, diabetes, depression, hypertension, and various infections. Berberine hydrochloride Chemical Structure
  85. GN10523 Berberine Sulfate Berberine Sulfate Chemical Structure
  86. GN10539 Bergenin

    (-)-Bergenin, Cuscutin, NSC 661749

     Bergenin Chemical Structure
  87. GC10734 Beta-Lapachone

    ARQ 501, NSC 26326, NSC 629749, SL 11001

     Beta-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression. Beta-Lapachone Chemical Structure
  88. GC10480 Betulinic acid

    Lupatic Acid, NSC 113090

     Betulinic acid is a natural pentacyclic triterpenoid compound and an inhibitor of eukaryotic topoisomerase I with an IC50 value of 5 μM. Betulinic acid Chemical Structure
  89. GC10037 Bexarotene

    LG 100069, LGD 1069, Ro 264455, SR 11247

     Retinoid Receptor agonist Bexarotene Chemical Structure
  90. GC46923 Bexarotene-d4

    LGD1069 D4

     A neuropeptide with diverse biological activities Bexarotene-d4 Chemical Structure
  91. GC10060 BEZ235 (NVP-BEZ235)

    Dactolisib

     NVP-BEZ235 is a novel therapeutic agent that targets 2 molecules in thePI3K/Akt/mTOR (phosphatidylinositol 3-kinase) pathway, PI3K and mTOR. BEZ235 (NVP-BEZ235) Chemical Structure
  92. GC13271 BEZ235 Tosylate BEZ235 Tosylate Chemical Structure
  93. GC35509 BGT226

    NVP-BGT226

     BGT226 (NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells. BGT226 Chemical Structure
  94. GC13468 BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable BI-D1870 Chemical Structure
  95. GC18174 BIA 10-2474 BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme). BIA 10-2474 Chemical Structure
  96. GC12271 Bicalutamide

    ICI 176334, ZD 176334

     Androgen receptor antagonist Bicalutamide Chemical Structure
  97. GC18304 Bicyclol Bicyclol is a hepatoprotective agent. Bicyclol Chemical Structure
  98. GC60076 Bigelovin Bigelovin, a sesquiterpene lactone isolated from Inula helianthus-aquatica, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation. Bigelovin Chemical Structure
  99. GC12218 BIIB021

    CNF2024

     A potent, orally-available Hsp90 inhibitor BIIB021 Chemical Structure
  100. GC12541 Bilobalide A neuroprotective natural product Bilobalide Chemical Structure
  101. GN10618 Biochanin A

    4’-methyl Genistein, 5,7-dihydroxy-4'-Methoxyisoflavone, NSC 123538

     Biochanin A Chemical Structure

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