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Ubiquitination/ Proteasome

Products for  Ubiquitination/ Proteasome

  1. Cat.No. Product Name Information
  2. GC12326 Amsacrine Topoisomerase 2 inhibitor Amsacrine  Chemical Structure
  3. GC11747 Amsacrine hydrochloride Topoisomerase 2 inhibitor Amsacrine hydrochloride  Chemical Structure
  4. GN10718 Andrographolide Andrographolide  Chemical Structure
  5. GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

    An androgenic steroid

    Androsterone (5α-Androstan-3α-ol-17-one)  Chemical Structure
  6. GC14292 Apatinib Mesylate

    Apatinib blocks the downstream signal transduction of VEGF pathway to inhibit neovascularization.

    Apatinib Mesylate  Chemical Structure
  7. GN10150 Apigenin

    Apigenin is a competitive CYP2C9 inhibitor with a Ki of 2 μM.

    Apigenin  Chemical Structure
  8. GC16237 Apocynin Selective NADPH-oxidase inhibitor Apocynin  Chemical Structure
  9. GC65004 Apostatin-1 Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1  Chemical Structure
  10. GC14590 AR-42 (OSU-HDAC42)

    HDAC inhibitor,novel and potent

    AR-42 (OSU-HDAC42)  Chemical Structure
  11. GC19035 AR7 A retinoic acid receptor α (RARα) antagonist AR7  Chemical Structure
  12. GN10063 Arctigenin Arctigenin  Chemical Structure
  13. GC12784 Artemether (SM-224) An antiparasitic compound Artemether (SM-224)  Chemical Structure
  14. GC12474 AS-605240 Potent and selective PI 3-Kγ inhibitor AS-605240  Chemical Structure
  15. GC62309 AS1708727 AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively. AS1708727  Chemical Structure
  16. GC19040 AS1842856

    AS1842856 is a cell permeable inhibitor that inhibits Foxo1 transcriptional activity with IC50=33 nM.

    AS1842856  Chemical Structure
  17. GC40769 Asperphenamate Asperphenamate is a fungal secondary metabolite originally isolated from A. Asperphenamate  Chemical Structure
  18. GC15706 Aspirin (Acetylsalicylic acid) A non-selective, irreversible COX inhibitor Aspirin (Acetylsalicylic acid)  Chemical Structure
  19. GC11106 AT-101 AT-101  Chemical Structure
  20. GC10638 AT9283 A broad spectrum kinase inhibitor AT9283  Chemical Structure
  21. GC35419 Atorvastatin Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1]. Atorvastatin  Chemical Structure
  22. GC14038 Atorvastatin Calcium An HMG-CoA reductase inhibitor Atorvastatin Calcium  Chemical Structure
  23. GC16526 Atropine MAChRs antagonist Atropine  Chemical Structure
  24. GC63827 Atropine sulfate monohydrate Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect. Atropine sulfate monohydrate  Chemical Structure
  25. GC62853 Aumitin Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin  Chemical Structure
  26. GC46897 AUTEN-99 AUTEN-99 (hydrobromide) is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14). AUTEN-99  Chemical Structure
  27. GC33683 Autocamtide 2 (Autocamtide II) Autocamtide 2 (Autocamtide II) is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 (Autocamtide II)  Chemical Structure
  28. GC34390 Autocamtide 2, amide Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays. Autocamtide 2, amide  Chemical Structure
  29. GC35432 Autocamtide-2-related inhibitory peptide (TFA) Autocamtide-2-related inhibitory peptide (TFA)  Chemical Structure
  30. GC50305 Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide Autocamtide-2-related inhibitory peptide, myristoylated  Chemical Structure
  31. GC35433 Autogramin-1 Autogramin-1 potently inhibits autophagy induced by either starvation (IC50=0.17 μM) or mTORC1 inhibition (Rapamycin; IC50=0.44 μM). Autogramin-1  Chemical Structure
  32. GC35434 Autogramin-2 Autogramin-2 potently inhibits autophagy induced by either starvation (IC50=0.27 μM) or mTORC1 inhibition (Rapamycin; IC50=0.14 μM). Autogramin-2  Chemical Structure
  33. GC19453 Autophinib

    Autophinib is a potent autophagy inhibitor

    Autophinib  Chemical Structure
  34. GC15295 AUY922 (NVP-AUY922) An Hsp90 inhibitor AUY922 (NVP-AUY922)  Chemical Structure
  35. GC11081 Avermectin B1 An insecticide and anthelmintic Avermectin B1  Chemical Structure
  36. GC19479 AZ304

    A dual inhibitor

    AZ304  Chemical Structure
  37. GC35445 Azathramycin Azathramycin (Azaerythromycin A) is an antibiotic and targets ribosome. Azathramycin  Chemical Structure
  38. GC14189 AZD-3463 ALK/IGF1R inhibitor AZD-3463  Chemical Structure
  39. GC12660 AZD1208 A pan-Pim kinase inhibitor AZD1208  Chemical Structure
  40. GC13029 AZD2014 AZD2014 (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes. AZD2014  Chemical Structure
  41. GC11752 AZD5363 AZD5363 (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively. AZD5363  Chemical Structure
  42. GC16851 AZD6482

    PI3Kβ inhibitor,potent and selective

    AZD6482  Chemical Structure
  43. GC31924 AZD7624 AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624  Chemical Structure
  44. GC16380 AZD8055 MTOR inhibitor AZD8055  Chemical Structure
  45. GC14507 Azithromycin Antibiotic by inhibiting protein synthesis Azithromycin  Chemical Structure
  46. GC11304 Azithromycin Dihydrate Azithromycin Dihydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections. Azithromycin Dihydrate  Chemical Structure
  47. GC35462 Bafetinib

    Bcr-Abl/Lyn tyrosine kinase inhibitor

    Bafetinib  Chemical Structure
  48. GC17597 Bafilomycin A1

    Bafilomycin A1, a macrolide antibiotic isolated from the Streptomyces species, is an inhibitor of vacuolar H ATPase (V-ATPase).

    Bafilomycin A1  Chemical Structure
  49. GN10018 Baicalin

    A flavonoid with diverse biological activities

    Baicalin  Chemical Structure
  50. GN10590 Bakuchiol Bakuchiol  Chemical Structure
  51. GC30565 BAR502 A dual agonist of GP-BAR1 and FXR BAR502  Chemical Structure
  52. GC11572 Bardoxolone methyl A synthetic triterpenoid with potent anticancer and antidiabetic activity Bardoxolone methyl  Chemical Structure
  53. GC13035 Bay 11-7821

    A selective and irreversible NF-κB inhibitor

    Bay 11-7821  Chemical Structure
  54. GC18487 BC-1215 BC-1215 is an inhibitor of F-box protein 3 (FBXO3; IC50 = 0.9 μg/mL for Il-1β release). BC-1215  Chemical Structure
  55. GC62135 BC1618 BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618  Chemical Structure
  56. GN10443 Berbamine Berbamine  Chemical Structure
  57. GN10358 Berbamine hydrochloride Berbamine hydrochloride  Chemical Structure
  58. GN10221 Berberine

    Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase.

    Berberine  Chemical Structure
  59. GC35497 Berberine chloride hydrate Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties. Berberine chloride hydrate  Chemical Structure
  60. GN10208 Berberine hydrochloride

    Berberine hydrochloride is an isoquinoline alkaloid derived from the Ranunculaceae medicinal plant Coptis chinensis. It has various pharmacological activities such as anti-tumor, anti-inflammatory, and hypoglycemic activities.

    Berberine hydrochloride  Chemical Structure
  61. GN10523 Berberine Sulfate Berberine Sulfate  Chemical Structure
  62. GN10539 Bergenin Bergenin  Chemical Structure
  63. GC10734 Beta-Lapachone Beta-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression. Beta-Lapachone  Chemical Structure
  64. GC10480 Betulinic acid A plant triterpenoid similar to bile acids Betulinic acid  Chemical Structure
  65. GC10037 Bexarotene Retinoid Receptor agonist Bexarotene  Chemical Structure
  66. GC46923 Bexarotene-d4 A neuropeptide with diverse biological activities Bexarotene-d4  Chemical Structure
  67. GC10060 BEZ235 (NVP-BEZ235) A dual inhibitor of class I PI3Ks and mTOR BEZ235 (NVP-BEZ235)  Chemical Structure
  68. GC13271 BEZ235 Tosylate BEZ235 Tosylate  Chemical Structure
  69. GC35509 BGT226 BGT226 (NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells. BGT226  Chemical Structure
  70. GC13468 BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable BI-D1870  Chemical Structure
  71. GC18174 BIA 10-2474 BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme). BIA 10-2474  Chemical Structure
  72. GC12271 Bicalutamide Androgen receptor antagonist Bicalutamide  Chemical Structure
  73. GC18304 Bicyclol Bicyclol is a hepatoprotective agent. Bicyclol  Chemical Structure
  74. GC60076 Bigelovin Bigelovin, a sesquiterpene lactone isolated from Inula helianthus-aquatica, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation. Bigelovin  Chemical Structure
  75. GC12218 BIIB021 A potent, orally-available Hsp90 inhibitor BIIB021  Chemical Structure
  76. GC12541 Bilobalide A neuroprotective natural product Bilobalide  Chemical Structure
  77. GN10618 Biochanin A Biochanin A  Chemical Structure
  78. GC11497 BIRB 796 (Doramapimod) BIRB 796 (Doramapimod) (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. BIRB 796 (Doramapimod)  Chemical Structure
  79. GN10037 Bisdemethoxycurcumin Bisdemethoxycurcumin  Chemical Structure
  80. GC12171 BIX 01294 An inhibitor of G9a histone methyltransferase BIX 01294  Chemical Structure
  81. GC39481 BL-918 An ULK1 activator BL-918  Chemical Structure
  82. GC10593 BMS-582949 hydrochloride p38 MAPK inhibitor BMS-582949 hydrochloride  Chemical Structure
  83. GC42958 Boc-LRR-AMC Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Boc-LRR-AMC  Chemical Structure
  84. GC65318 BOLD-100 BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution. BOLD-100  Chemical Structure
  85. GC17644 Bortezomib (PS-341) Bortezomib (PS-341), as a dipeptide boronic acid proteasome inhibitor with antitumor activity, can potently inhibiit 20S proteasome with Ki of 0.6 nM by targeting a threonine residue.. Bortezomib (PS-341)  Chemical Structure
  86. GC65010 Bortezomib-d8 Bortezomib-d8 (PS-341-d8) is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity. Bortezomib-d8  Chemical Structure
  87. GC13343 Bosutinib (SKI-606) Bosutinib (SKI-606) is an oral Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively. Bosutinib (SKI-606)  Chemical Structure
  88. GC40080 Bosutinib-d8 Bosutinib-d8 is intended for use as an internal standard for the quantification of bosutinib by GC- or LC-MS. Bosutinib-d8  Chemical Structure
  89. GC30537 BPO-27 racemate BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. BPO-27 racemate  Chemical Structure
  90. GN10802 Brazilin Brazilin  Chemical Structure
  91. GC17683 Brefeldin A

    Brefeldin A (BFA) is a fungal macrocyclic lactone and a potent, reversible inhibitor of intracellular vesicle formation and protein trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus.

    Brefeldin A  Chemical Structure
  92. GC35554 Brevilin A A sesquiterpene lactone with anticancer activity Brevilin A  Chemical Structure
  93. GC19083 Briciclib Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers. Briciclib  Chemical Structure
  94. GC35555 Britannin Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone. Britannin  Chemical Structure
  95. GC11692 Brivanib (BMS-540215) Brivanib (BMS-540215) (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM, and has moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Brivanib (BMS-540215)  Chemical Structure
  96. GC14238 Brivanib Alaninate (BMS-582664) Brivanib alaninate (BMS-582664) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ. Brivanib Alaninate (BMS-582664)  Chemical Structure
  97. GC16921 Bromhexine HCl Bromhexine HCl is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine HCl  Chemical Structure
  98. GC13931 Bromocriptine mesylate

    D2-like dopamine receptor agonist

    Bromocriptine mesylate  Chemical Structure
  99. GC16531 Bromodomain Inhibitor, (+)-JQ1 A selective inhibitor of BET bromodomains Bromodomain Inhibitor, (+)-JQ1  Chemical Structure
  100. GC10944 Butein Protein kinase inhibitor Butein  Chemical Structure
  101. GC43048 C18 dihydro Ceramide (d18:0/18:0)

    A bioactive sphingolipid

    C18 dihydro Ceramide (d18:0/18:0)  Chemical Structure

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