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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome

Products for  Ubiquitination/ Proteasome

  1. Cat.No. Product Name Information
  2. GC11497 BIRB 796 (Doramapimod)

    BIRB796

     BIRB 796 (Doramapimod) (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. BIRB 796 (Doramapimod) Chemical Structure
  3. GN10037 Bisdemethoxycurcumin

    BDMC

     Bisdemethoxycurcumin Chemical Structure
  4. GC12171 BIX 01294 An inhibitor of G9a histone methyltransferase BIX 01294 Chemical Structure
  5. GC39481 BL-918 An ULK1 activator BL-918 Chemical Structure
  6. GC10593 BMS-582949 hydrochloride p38 MAPK inhibitor BMS-582949 hydrochloride Chemical Structure
  7. GC42958 Boc-LRR-AMC

    Boc-Leu-Arg-Arg-AMC, Boc-Leu-Arg-Arg-7-amido-4-Methylcoumarin

     Boc-LRR-AMC is a fluorescent substrate for Trypsin, similar to the 20S proteasome. Boc-LRR-AMC Chemical Structure
  8. GC90276 Boc-LRR-AMC (trifluoroacetate salt)

    A fluorogenic substrate for trypsin-like activity of the 26S proteasome or 20S proteolytic core

     Boc-LRR-AMC (trifluoroacetate salt) Chemical Structure
  9. GC65318 BOLD-100

    NKP-1339 free base; IT-139 free base; KP-1339 free base

     BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 Chemical Structure
  10. GC17644 Bortezomib (PS-341)

    LDP-341, MG-341, MLN341, NSC 681239, PS-341

    Bortezomib (PS-341), as a dipeptide boronic acid proteasome inhibitor with antitumor activity, can potently inhibiit 20S proteasome with Ki of 0.6 nM by targeting a threonine residue.

     Bortezomib (PS-341) Chemical Structure
  11. GC46942 Bortezomib-d15

    LDP-341-d15, MG-341-d15, PS-341-d15

     A neuropeptide with diverse biological activities Bortezomib-d15 Chemical Structure
  12. GC65010 Bortezomib-d8

    PS-341-d8; LDP-341-d8; NSC 681239-d8

     Bortezomib-d8 (PS-341-d8) is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity. Bortezomib-d8 Chemical Structure
  13. GC13343 Bosutinib (SKI-606)

    SKI 606

     Bosutinib (SKI-606) is an oral Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively. Bosutinib (SKI-606) Chemical Structure
  14. GC40080 Bosutinib-d8

    SKI-606 D8

     Bosutinib-d8 is intended for use as an internal standard for the quantification of bosutinib by GC- or LC-MS. Bosutinib-d8 Chemical Structure
  15. GC30537 BPO-27 racemate BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. BPO-27 racemate Chemical Structure
  16. GN10802 Brazilin

    (+)Brazilin, NSC 56652

     Brazilin Chemical Structure
  17. GC17683 Brefeldin A

    Ascotoxin, BFA, Cyanein, Decumbin, Nectrolide, NSC 56310, NSC 89671, NSC 107456, NSC 244390, Synergisidin

     Brefeldin A (BFA) is a fungal macrocyclic lactone and a potent, reversible inhibitor of intracellular vesicle formation and protein trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus. Brefeldin A Chemical Structure
  18. GC35554 Brevilin A

    6-O-Angeloylprenolin, Brevelin A

     A sesquiterpene lactone with anticancer activity Brevilin A Chemical Structure
  19. GC19083 Briciclib

    ON-014185

     Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers. Briciclib Chemical Structure
  20. GC35555 Britannin Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone. Britannin Chemical Structure
  21. GC11692 Brivanib (BMS-540215)

    BMS 540215

     Brivanib (BMS-540215) (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM, and has moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Brivanib (BMS-540215) Chemical Structure
  22. GC14238 Brivanib Alaninate (BMS-582664)

    BMS 582664

     Brivanib alaninate (BMS-582664) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ. Brivanib Alaninate (BMS-582664) Chemical Structure
  23. GC16921 Bromhexine HCl Bromhexine HCl is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine HCl Chemical Structure
  24. GC13931 Bromocriptine mesylate

    CB-154

    D2-like dopamine receptor agonist

     Bromocriptine mesylate Chemical Structure
  25. GC16531 Bromodomain Inhibitor, (+)-JQ1 A selective inhibitor of BET bromodomains Bromodomain Inhibitor, (+)-JQ1 Chemical Structure
  26. GC10944 Butein

    2’,3,4,4’tetrahydroxy Chalcone

     Protein kinase inhibitor Butein Chemical Structure
  27. GC43048 C18 dihydro Ceramide (d18:0/18:0)

    Cer(d18:0/18:0)

    A bioactive sphingolipid

     C18 dihydro Ceramide (d18:0/18:0) Chemical Structure
  28. GC46989 C18 dihydro Ceramide-d3 (d18:0/18:0-d3)

    N-octadecanoyl-D-erythro-Dihydrosphingosine-d3, Cer(d18:0/18:0)-d3, Ceramide-d3 (d18:0/18:0-d3)

     C18 dihydro Ceramide-d3 (d18:0/18:0-d3) Chemical Structure
  29. GC13892 C527 Inhibitor of USP1/USF1 complex C527 Chemical Structure
  30. GC17912 C598-0466

    USP7 inhibitor

     C598-0466 Chemical Structure
  31. GC45616 C6 Urea Ceramide

    C6 Ceramide (d18:1/6:0) Urea, Cer(d18:1/6:0) Urea, D-erythro-Urea-C6-Ceramide

     An inhibitor of neutral ceramidase C6 Urea Ceramide Chemical Structure
  32. GC12733 C646 C646, a potent and selective p300/CBP histone acetyltransferase inhibitor (Ki 400 nM), has been shown to have pleiotropic activity, including neuroprotective, anti-cancer and anti-epithelial-mesenchymal transition (anti-EMT) effects. C646 Chemical Structure
  33. GC43105 C8 Ceramide (d18:1.8:0)

    N-octanoyl-D-erythro-Sphingosine

     C8 Ceramide (d18:1.8:0) (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8 Ceramide (d18:1.8:0) Chemical Structure
  34. GC33218 CA-5f A potent late-stage macroautophagy/autophagy inhibitor CA-5f Chemical Structure
  35. GC62881 CA77.1 CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 Chemical Structure
  36. GC11765 Cabazitaxel

    TXD 258, XRP 6258

     Microtubule associated inhibitor Cabazitaxel Chemical Structure
  37. GC65575 Cabazitaxel-d6 Cabazitaxel-d6 (XRP6258-d6) is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel-d6 Chemical Structure
  38. GC10441 Cabergoline

    FCE 21336

     potent dopamine receptor agonist Cabergoline Chemical Structure
  39. GC71212 Cabergoline-d5 Cabergoline-d5 is the deuterium labeled Cabergoline. Cabergoline-d5 Chemical Structure
  40. GC47016 Cabergoline-d6

    FCE-21336-d6

     A neuropeptide with diverse biological activities Cabergoline-d6 Chemical Structure
  41. GC13396 CAL-101 (Idelalisib, GS-1101)

    GS1101, Idelalisib

     A selective PI3K p110δ inhibitor CAL-101 (Idelalisib, GS-1101) Chemical Structure
  42. GC60668 Calcimycin hemimagnesium Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium Chemical Structure
  43. GC30990 Calcineurin substrate Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. Calcineurin substrate Chemical Structure
  44. GC38629 Calcineurin substrate (TFA) Calcineurin substrate (TFA) Chemical Structure
  45. GC14326 Calmidazolium chloride

    R 24571

    Calmodulin antagonist

     Calmidazolium chloride Chemical Structure
  46. GC31170 Calmodulin-Dependent Protein Kinase II 290-309 Calmodulin-Dependent Protein Kinase II 290-309 is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Calmodulin-Dependent Protein Kinase II 290-309 Chemical Structure
  47. GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Calmodulin-Dependent Protein Kinase II(290-309) acetate Chemical Structure
  48. GC12527 Calpain Inhibitor I, ALLN

    AcLeuLeuNleAldehyde, ALLN, MG 101

     A non-selective cysteine protease inhibitor Calpain Inhibitor I, ALLN Chemical Structure
  49. GC40694 Calpain Inhibitor II

    AcLeuLeuMetH, ALLM

     Calpain Inhibitor II (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. Calpain Inhibitor II Chemical Structure
  50. GC67908 Calpain-2-IN-1 Calpain-2-IN-1 Chemical Structure
  51. GC10342 Calpeptin

    A calpain inhibitor

     Calpeptin Chemical Structure
  52. GC35601 CaMKII-IN-1 CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC. CaMKII-IN-1 Chemical Structure
  53. GC14065 Capsaicin Capsaicin is a highly selective agonist for the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), a ligand-gated, nonselective cation channel, preferentially expressed on small-diameter sensory neurons. Capsaicin Chemical Structure
  54. GC32815 Capzimin Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor. Capzimin Chemical Structure
  55. GC17340 Carbamazepine Inhibitor of neuronal voltage-gated Na+ channels Carbamazepine Chemical Structure
  56. GC11207 Carboplatin

    CBDCA, CDDCA, cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), NSC 201345, NSC 241240

     Carboplatin (NSC 241240) is a non-specific DNA cross-linking agent that inhibits DNA synthesis and transcription. Its main target is DNA rather than specific proteins . Carboplatin Chemical Structure
  57. GC15089 Carfilzomib (PR-171)

    PR-171

     A proteasome inhibitor Carfilzomib (PR-171) Chemical Structure
  58. GC43144 Carfilzomib Impurity 13 (hydrochloride) Carfilzomib impurity 13 (hydrochloride) is a potential impurity found in commercial carfilzomib preparations. Carfilzomib Impurity 13 (hydrochloride) Chemical Structure
  59. GC47042 Carfilzomib-d8 An internal standard for the quantification of carfilzomib Carfilzomib-d8 Chemical Structure
  60. GC17341 Carprofen

    Carprodyl, NSC 297935

     COX inhibitor Carprofen Chemical Structure
  61. GC14769 Carvedilol

    BM 14190

     Potent β-adrenoceptor and α1-adrenoceptor antagonist Carvedilol Chemical Structure
  62. GC35613 Carvedilol phosphate hemihydrate Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker. Carvedilol phosphate hemihydrate Chemical Structure
  63. GC64003 Carvedilol-d4

    BM 14190-d4

     Carvedilol-d4 Chemical Structure
  64. GC43189 CAY10681 Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer. CAY10681 Chemical Structure
  65. GC47065 CAY10773 A derivative of sorafenib CAY10773 Chemical Structure
  66. GC16351 CB-5083

    p97 inhibitor

     CB-5083 Chemical Structure
  67. GC20117 CB-5339

    CB-5339 is a second generation, potent and selective, orally bioavailable, ATP-competitive, small molecule inhibitor of valosin containing protein (VCP)/p97 [1,2].

     CB-5339 Chemical Structure
  68. GC15227 CB-839

    Telaglenastat

     Telaglenastat (CB-839) is a first-in-class, reversible and orally bioavailable glutaminase 1 (GLS1) inhibitor. CB-839 Chemical Structure
  69. GC33006 CCT020312 CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 Chemical Structure
  70. GC15864 CCT128930 AKT inhibitor CCT128930 Chemical Structure
  71. GC11464 CD 437

    CD437

     RARγ-selective agonist,potent and cell-permeable CD 437 Chemical Structure
  72. GC61865 Cearoin Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK. Cearoin Chemical Structure
  73. GC16421 Cediranib (AZD217)

    AZD 2171, ZD 2171

     Cediranib (AZD217) (AZD2171) is a highly potent, orally available VEGFR tyrosine kinase inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively. Cediranib (AZD217) Chemical Structure
  74. GC33004 Cediranib maleate (AZD-2171 maleate) Cediranib maleate (AZD-2171 maleate) (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively. Cediranib maleate (AZD-2171 maleate) Chemical Structure
  75. GC15083 Celastrol Celastrol is a proteasome inhibitor with a potent and preferred inhibition of purified 20S proteasome with an IC50 of 2.5 μM. Celastrol Chemical Structure
  76. GC92062 CellFluor™ GST

    Cell Fluor™ Glutathione S-Transferase; DNs-Rh; bis-DNs-Rh

     CellFluor GST is a cell-permeable quenched fluorescent probe for the detection of pan-glutathione S-transferase activity in adherent or suspension cells, cell or tissue lysates, or purified enzyme preparations. CellFluor™ GST Chemical Structure
  77. GC12272 CEP-18770

    CEP-18770

     An inhibitor of chymotrypsin-like proteasome activity CEP-18770 Chemical Structure
  78. GN10113 Cepharanthine

    O-Methylcepharanoline, NSC 623442

     Cepharanthine Chemical Structure
  79. GC73469 Cereblon inhibitor 2 Cereblon inhibitor 2 (compound 8) is a Cereblon inhibitor useful in solid tumor research, especially breast cancer. Cereblon inhibitor 2 Chemical Structure
  80. GC60688 Cereblon modulator 1

    CC-90009

     Cereblon modulator 1 (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Cereblon modulator 1 Chemical Structure
  81. GC35667 CFTR corrector 1

    VX-445

     CFTR corrector 1 (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). CFTR corrector 1 Chemical Structure
  82. GC34532 CFTR corrector 2 CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933. CFTR corrector 2 Chemical Structure
  83. GC14421 CFTRinh-172

    CFTR(inh)172, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor 172

     CFTR inhibitor, highly potent and selective CFTRinh-172 Chemical Structure
  84. GC35668 CG-200745

    CG-200745

     CG-200745 (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG-200745 inhibits deacetylation of histone H3 and tubulin. CG-200745 induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. CG-200745 enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil (5-FU; ). CG-200745 induces apoptosis and has anti-tumour effects. CG-200745 Chemical Structure
  85. GC13365 CGI-1746 A potent, selective BTK inhibitor CGI-1746 Chemical Structure
  86. GN10463 Chelerythrine Chelerythrine Chemical Structure
  87. GC13065 Chelerythrine Chloride

    Broussonpapyrine chloride, NSC 646662

     Potent inhibitor of PKC and Bcl-xL Chelerythrine Chloride Chemical Structure
  88. GC17985 Chenodeoxycholic Acid

    CDCA

     nuclear receptors(FXR) activator Chenodeoxycholic Acid Chemical Structure
  89. GC15642 CHIR 99021 trihydrochloride

    CHIR-99021 trihydrochloride; CT99021 trihydrochloride

     Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR 99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR 99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR 99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR 99021 trihydrochloride induces autophagy. CHIR 99021 trihydrochloride Chemical Structure
  90. GC16702 CHIR-99021 (CT99021)

    CHIR99021, CHIR-99021, CHIR 99021, CT99021,GSK-3 Inhibitor XVI

     CHIR-99021 is the most commonly used GSK-3β inhibitor and is considered the standard small-molecule Wnt agonist. CHIR-99021 (CT99021) Chemical Structure
  91. GC32942 CHIR-99021 monohydrochloride (CT99021 monohydrochloride) CHIR-99021 monohydrochloride (CT99021 monohydrochloride) Chemical Structure
  92. GN10518 Chitosamine hydrochloride

    D-(+)-Glucosamine, GlcN, NSC 234443, NSC 758

     Chitosamine hydrochloride Chemical Structure
  93. GC60700 Chloroquine D5 Chloroquine D5 is deuterium labeled Chloroquine. Chloroquine D5 Chemical Structure
  94. GC10295 Chloroquine diphosphate

    DL-Chloroquine, NSC 14050

     Chloroquine diphosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine diphosphate Chemical Structure
  95. GC45885 Chloroquine-d5 (phosphate)

    DL-Chloroquine-d5

     An internal standard for the quantification of chloroquine Chloroquine-d5 (phosphate) Chemical Structure
  96. GC14216 Chlorpromazine HCl

    CPZ

     Chlorpromazine HCl is an orally effective, blood-brain-permeable phenothiazine antipsychotic that can effectively antagonize D2 dopamine receptors and 5-HT2A and has a strong sedative effect. Chlorpromazine HCl Chemical Structure
  97. GC43265 Chromomycin A2

    Aburamycin A, CMA2, NSC 131187

     Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. Chromomycin A2 Chemical Structure
  98. GC10132 Ciclopirox

    HOE 296b

     broad-spectrum antifungal agent Ciclopirox Chemical Structure
  99. GC13559 Cilengitide

    EMD 121974

     Integrin inhibitor for αvβ3 and αvβ5 Cilengitide Chemical Structure
  100. GC61520 Cilengitide TFA

    EMD 121974 TFA

     Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively. Cilengitide TFA Chemical Structure
  101. GC18212 Cilofexor

    GS-9674

     Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay). Cilofexor Chemical Structure

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