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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. Product Name Information
  2. GC11207 Carboplatin

    Antitumor agent that forms platinum-DNA adducts.

     Carboplatin Chemical Structure
  3. GC15089 Carfilzomib (PR-171) A proteasome inhibitor Carfilzomib (PR-171) Chemical Structure
  4. GC17341 Carprofen COX inhibitor Carprofen Chemical Structure
  5. GC14769 Carvedilol Potent β-adrenoceptor and α1-adrenoceptor antagonist Carvedilol Chemical Structure
  6. GC35613 Carvedilol phosphate hemihydrate Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker. Carvedilol phosphate hemihydrate Chemical Structure
  7. GC64003 Carvedilol-d4 Carvedilol-d4 Chemical Structure
  8. GC47065 CAY10773 A derivative of sorafenib CAY10773 Chemical Structure
  9. GC15227 CB-839 CB-839 (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. CB-839 selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. CB-839 inudces autophagy and has antitumor activity. CB-839 Chemical Structure
  10. GC33006 CCT020312 CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 Chemical Structure
  11. GC15864 CCT128930 AKT inhibitor CCT128930 Chemical Structure
  12. GC11464 CD 437 RARγ-selective agonist,potent and cell-permeable CD 437 Chemical Structure
  13. GC61865 Cearoin Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK. Cearoin Chemical Structure
  14. GC16421 Cediranib (AZD217) Cediranib (AZD217) (AZD2171) is a highly potent, orally available VEGFR tyrosine kinase inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively. Cediranib (AZD217) Chemical Structure
  15. GC33004 Cediranib maleate (AZD-2171 maleate) Cediranib maleate (AZD-2171 maleate) (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively. Cediranib maleate (AZD-2171 maleate) Chemical Structure
  16. GC15083 Celastrol A triterpenoid antioxidant Celastrol Chemical Structure
  17. GN10113 Cepharanthine Cepharanthine Chemical Structure
  18. GC35667 CFTR corrector 1 CFTR corrector 1 (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). CFTR corrector 1 Chemical Structure
  19. GC34532 CFTR corrector 2 CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933. CFTR corrector 2 Chemical Structure
  20. GC14421 CFTRinh-172 CFTR inhibitor, highly potent and selective CFTRinh-172 Chemical Structure
  21. GC35668 CG-200745 CG-200745 (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG-200745 inhibits deacetylation of histone H3 and tubulin. CG-200745 induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. CG-200745 enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil (5-FU; ). CG-200745 induces apoptosis and has anti-tumour effects. CG-200745 Chemical Structure
  22. GC13365 CGI-1746 A potent, selective BTK inhibitor CGI-1746 Chemical Structure
  23. GN10463 Chelerythrine Chelerythrine Chemical Structure
  24. GC13065 Chelerythrine Chloride Potent inhibitor of PKC and Bcl-xL Chelerythrine Chloride Chemical Structure
  25. GC17985 Chenodeoxycholic Acid nuclear receptors(FXR) activator Chenodeoxycholic Acid Chemical Structure
  26. GC48595 Chenodeoxycholic Acid MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Chenodeoxycholic Acid MaxSpec® Standard Chemical Structure
  27. GC15642 CHIR 99021 trihydrochloride Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR 99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR 99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR 99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR 99021 trihydrochloride induces autophagy. CHIR 99021 trihydrochloride Chemical Structure
  28. GC16702 CHIR-99021 (CT99021)

    A selective GSK3 inhibitor

     CHIR-99021 (CT99021) Chemical Structure
  29. GC32942 CHIR-99021 monohydrochloride (CT99021 monohydrochloride) CHIR-99021 monohydrochloride (CT99021 monohydrochloride) Chemical Structure
  30. GN10518 Chitosamine hydrochloride Chitosamine hydrochloride Chemical Structure
  31. GC60700 Chloroquine D5 Chloroquine D5 is deuterium labeled Chloroquine. Chloroquine D5 Chemical Structure
  32. GC10295 Chloroquine diphosphate Chloroquine diphosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine diphosphate Chemical Structure
  33. GC45885 Chloroquine-d5 (phosphate) An internal standard for the quantification of chloroquine Chloroquine-d5 (phosphate) Chemical Structure
  34. GC14216 Chlorpromazine HCl

    dopamine receptor antagonist

     Chlorpromazine HCl Chemical Structure
  35. GC43265 Chromomycin A2 Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. Chromomycin A2 Chemical Structure
  36. GC10132 Ciclopirox broad-spectrum antifungal agent Ciclopirox Chemical Structure
  37. GC13559 Cilengitide Integrin inhibitor for αvβ3 and αvβ5 Cilengitide Chemical Structure
  38. GC61520 Cilengitide TFA Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively. Cilengitide TFA Chemical Structure
  39. GC18212 Cilofexor Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay). Cilofexor Chemical Structure
  40. GC15890 Cilostazol A PDE3A inhibitor Cilostazol Chemical Structure
  41. GN10189 Cinobufagin Cinobufagin Chemical Structure
  42. GC12226 Cisatracurium Besylate Neuromuscular-blocking drug Cisatracurium Besylate Chemical Structure
  43. GC14035 Citalopram hydrobromide 5-HT uptake inhibitor Citalopram hydrobromide Chemical Structure
  44. GC16754 Clarithromycin A macrolide antibiotic Clarithromycin Chemical Structure
  45. GC14892 Clemastine Fumarate Selective histamine H1 receptor antagonist Clemastine Fumarate Chemical Structure
  46. GC64524 Clematichinenoside AR Clematichinenoside AR is a major active ingredient that could be extracted from the traditional Chinese herb Clematis chinensis and has potent pharmacological effects on various diseases, including atherosclerosis (AS). Clematichinenoside AR Chemical Structure
  47. GC15810 Clinofibrate HMGCR inhibitor Clinofibrate Chemical Structure
  48. GC32078 Clioquinol (Iodochlorhydroxyquin) Clioquinol (Iodochlorhydroxyquin) (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol (Iodochlorhydroxyquin) Chemical Structure
  49. GC15219 Clofarabine Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase Clofarabine Chemical Structure
  50. GC16804 Clotrimazole antifungal compound Clotrimazole Chemical Structure
  51. GC13261 Colchicine

    An inhibitor of microtubule polymerization

     Colchicine Chemical Structure
  52. GC16332 Colistin Sulfate Cationic polypeptide antibiotic Colistin Sulfate Chemical Structure
  53. GC17519 Concanamycin A

    V-type (vacuolar) H+-ATPase inhibitor

     Concanamycin A Chemical Structure
  54. GN10810 Cordycepin Cordycepin Chemical Structure
  55. GN10015 Corosolic Acid Corosolic Acid Chemical Structure
  56. GC32959 Corynoxine An indole alkaloid Corynoxine Chemical Structure
  57. GC52477 Corynoxine (hydrochloride) An indole alkaloid Corynoxine (hydrochloride) Chemical Structure
  58. GC32826 Corynoxine B Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer. Corynoxine B Chemical Structure
  59. GC14906 Crenolanib (CP-868596) Crenolanib (CP-868596) is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with Kds of 0.74 nM and 2.1 nM/3.2 nM, respectively. Crenolanib (CP-868596) Chemical Structure
  60. GC30360 Cresol (Cresol mixture of isomers) Cresol (Cresol mixture of isomers) Chemical Structure
  61. GC12616 Crizotinib hydrochloride

    inhibitor of the c-Met kinase and the NPM-ALK

     Crizotinib hydrochloride Chemical Structure
  62. GN10501 Cryptotanshinone Cryptotanshinone Chemical Structure
  63. GN10535 Cucurbitacin B Cucurbitacin B Chemical Structure
  64. GN10526 Cucurbitacin E Cucurbitacin E Chemical Structure
  65. GC14787 Curcumin A yellow pigment with diverse biological activities Curcumin Chemical Structure
  66. GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS. Curcumin-d6 Chemical Structure
  67. GC14495 CX 546 AMPA receptor potentiator CX 546 Chemical Structure
  68. GC13037 CX-4945 (Silmitasertib) CX-4945 (Silmitasertib) (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. CX-4945 (Silmitasertib) Chemical Structure
  69. GC11325 CX-4945 sodium salt CX-4945 sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. CX-4945 sodium salt Chemical Structure
  70. GC17795 Cyclocytidine HCl Ancitabine (hydrochloride) is an important antileukemia drugs. Cyclocytidine HCl Chemical Structure
  71. GC38419 Cyclovirobuxine D An alkaloid with diverse biological activities Cyclovirobuxine D Chemical Structure
  72. GC43354 Cysmethynil Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. Cysmethynil Chemical Structure
  73. GC33779 Cysteamine (β-Mercaptoethylamine) Cysteamine (β-Mercaptoethylamine) Chemical Structure
  74. GC13502 Cysteamine HCl Cysteamine HCl (2-Aminoethanethiol hydrochloride) is an orally active agent for the treatment of nephropathic cystinosis and an antioxidant. Cysteamine HCl Chemical Structure
  75. GC17050 CYT387 A potent inhibitor of JAK1 and JAK2 CYT387 Chemical Structure
  76. GC16468 CYT387 sulfate salt A potent inhibitor of JAK1 and JAK2 CYT387 sulfate salt Chemical Structure
  77. GC13070 Cytarabine Cytotoxic agent, blocks DNA synthesis Cytarabine Chemical Structure
  78. GC14961 Cytarabine hydrochloride DNA synthsis inhibitor Cytarabine hydrochloride Chemical Structure
  79. GC43359 Cytochalasin E The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. Cytochalasin E Chemical Structure
  80. GC40792 D-threo Sphinganine (d18:0) D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0). D-threo Sphinganine (d18:0) Chemical Structure
  81. GC13202 D4476 Inhibitor of CK1 and ALK5 D4476 Chemical Structure
  82. GN10318 Danshensu Danshensu Chemical Structure
  83. GC34010 Danshensu (Dan shen suan A)

    Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.

     Danshensu (Dan shen suan A) Chemical Structure
  84. GC30072 Dansylcadaverine (Monodansyl cadaverine) Dansylcadaverine (Monodansyl cadaverine) (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine (Monodansyl cadaverine) Chemical Structure
  85. GC30056 Danthron (Dantron) Danthron (Dantron) is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron (Dantron) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron (Dantron) Chemical Structure
  86. GC30054 Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate) Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate) is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate) Chemical Structure
  87. GC15217 Danusertib (PHA-739358) A pan-Aurora kinase and Abl inhibitor Danusertib (PHA-739358) Chemical Structure
  88. GN10336 Daphnetin Daphnetin Chemical Structure
  89. GC12942 DAPT (GSI-IX)

    Inhibitor of γ-secretase

     DAPT (GSI-IX) Chemical Structure
  90. GC15568 Dasatinib (BMS-354825) An inhibitor of Abl and Src Dasatinib (BMS-354825) Chemical Structure
  91. GC35812 Dasatinib hydrochloride A potent and dual AblWT/Src inhibitor Dasatinib hydrochloride Chemical Structure
  92. GC12828 Daunorubicin

    DNA topoisomerase II inhibitor

     Daunorubicin Chemical Structure
  93. GC10354 Daunorubicin HCl Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin HCl Chemical Structure
  94. GC33003 Daurisoline ((R,R)-Daurisoline) Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor and also an autophagy blocker. Daurisoline ((R,R)-Daurisoline) Chemical Structure
  95. GC10824 DBeQ P97 ATPase inhibitor DBeQ Chemical Structure
  96. GC65191 DC-LC3in-D5 DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 Chemical Structure
  97. GC19485 DC661

    A potent PPT1 inhibitor

     DC661 Chemical Structure
  98. GC35820 DDD107498 succinate DDD107498 succinate (DDD-498 succinate) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. DDD107498 succinate Chemical Structure
  99. GC13554 Deferoxamine mesylate

    Deferoxamine mesylate is a drug that chelates iron by forming a stable complex that prevents the iron from entering into further chemical reactions, and is used for the treatment of chronic iron overload in patients with transfusion-dependent anemias.

     Deferoxamine mesylate Chemical Structure
  100. GC15484 Deguelin A potent antiproliferative rotenoid compound Deguelin Chemical Structure
  101. GC35832 Dehydrocorydaline chloride An alkaloid with diverse biological activities Dehydrocorydaline chloride Chemical Structure

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