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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. Product Name Information
  2. GC38528 Dehydropachymic acid Dehydropachymic acid is one of the major triterpenes isolated from Poria cocos. Dehydropachymic acid Chemical Structure
  3. GN10529 Demethoxycurcumin Demethoxycurcumin Chemical Structure
  4. GC38564 Deoxypodophyllotoxin Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from rhizomes of Sinopodophullumhexandrum (Berberidaceae). Deoxypodophyllotoxin Chemical Structure
  5. GC39372 Desethyl chloroquine diphosphate Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Desethyl chloroquine diphosphate Chemical Structure
  6. GC47193 Desethyl Hydroxychloroquine-d4 An internal standard for the quantification of desethyl hydroxychloroquine Desethyl Hydroxychloroquine-d4 Chemical Structure
  7. GC47194 Desethylchloroquine An active metabolite of chloroquine Desethylchloroquine Chemical Structure
  8. GC47195 Desethylchloroquine-d4 An internal standard for the quantification of desethylchloroquine Desethylchloroquine-d4 Chemical Structure
  9. GC64136 Desmethyl Naproxen-d3 Desmethyl Naproxen-d3 is deuterium labeled Desmethyl Naproxen. Desmethyl Naproxen-d3 Chemical Structure
  10. GC40775 Dexamethasone

    Dexamethasone, as one member of the glucocorticoid family, can protect against arthritis-related changes in cartilage structure and function, including matrix loss, inflammation and cartilage viability.

     Dexamethasone Chemical Structure
  11. GC14667 Dexamethasone (DHAP) Glucocorticoidan;anti-inflammatory Dexamethasone (DHAP) Chemical Structure
  12. GC11237 Dexamethasone acetate

    IL Receptor modulator

     Dexamethasone acetate Chemical Structure
  13. GC10750 Dexmedetomidine HCl Dexmedetomidine HCl ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine HCl Chemical Structure
  14. GC11598 Diazoxide

    positive allosteric modulator of the AMPA and kainate receptors

     Diazoxide Chemical Structure
  15. GC15578 Dienogest Orally active synthetic progesterone Dienogest Chemical Structure
  16. GN10056 Dihydroartemisinin Dihydroartemisinin Chemical Structure
  17. GN10583 Dihydromyricetin Dihydromyricetin Chemical Structure
  18. GC31697 Dilmapimod (SB-681323) Dilmapimod (SB-681323) (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease. Dilmapimod (SB-681323) Chemical Structure
  19. GC49016 Dimethyl 2-ketoglutarate An esterified form of α-ketoglutarate Dimethyl 2-ketoglutarate Chemical Structure
  20. GN10284 Dioscin Dioscin Chemical Structure
  21. GC38408 Diosgenin glucoside Diosgenin glucoside Chemical Structure
  22. GC15212 Divalproex Sodium Valproic acid (VPA) sodium (2:1) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Divalproex Sodium Chemical Structure
  23. GC14298 DMH-1 Selective BMP ALK2 receptor DMH-1 Chemical Structure
  24. GC16973 DMOG

    An HIF-PH inhibitor

     DMOG Chemical Structure
  25. GC17243 Dorsomorphin (Compound C) Dorsomorphin (Compound C) (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (Compound C) (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin (Compound C) induces autophagy. Dorsomorphin (Compound C) Chemical Structure
  26. GC12560 Dorsomorphin (Compound C) 2HCl Dorsomorphin (Compound C) 2HCl (BML-275 dihydrochloride; Compound C dihydrochloride) is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin (Compound C) 2HCl inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin (Compound C) 2HCl induces autophagy. Dorsomorphin (Compound C) 2HCl Chemical Structure
  27. GC13443 Doxazosin Mesylate α1-adrenergic receptor antagonist Doxazosin Mesylate Chemical Structure
  28. GC17567 Doxorubicin (Adriamycin) HCl Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin (Adriamycin) HCl Chemical Structure
  29. GC16073 Dronedarone An antiarrhythmic agent Dronedarone Chemical Structure
  30. GC12234 Dronedarone HCl Dronedarone HCl is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents. Dronedarone HCl Chemical Structure
  31. GC10395 Dynasore Dynasore, as a GTPase inhibitor, can rapidly and reversibly inhibit dynamin activity, which prevents endocytosis. Dynasore Chemical Structure
  32. GC13787 E 64d

    A protease inhibitor

     E 64d Chemical Structure
  33. GC13418 E-64 A fungal metabolite with diverse biological activities E-64 Chemical Structure
  34. GC39305 EACC EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC Chemical Structure
  35. GC10331 Ebselen A peroxynitrite scavenger Ebselen Chemical Structure
  36. GN10564 Ecdysterone Ecdysterone Chemical Structure
  37. GC12389 Efavirenz Reverse transcriptase inhibitor Efavirenz Chemical Structure
  38. GC35969 eIF4A3-IN-1 eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD. eIF4A3-IN-1 Chemical Structure
  39. GC65540 eIF4A3-IN-2 eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM. eIF4A3-IN-2 Chemical Structure
  40. GC12846 Elaiophylin Macrodiolide antibiotic Elaiophylin Chemical Structure
  41. GC10466 EMD-1214063 EMD-1214063 (Tepotinib, MSC2156119J) is a novel potent and highly selective reversible, ATP-competitive small molecule c-Met inhibitor . EMD-1214063 Chemical Structure
  42. GC43599 Emetine (hydrochloride) An anti-protozoal drug used for intestinal and tissue amoebiasis Emetine (hydrochloride) Chemical Structure
  43. GC32048 Emetine dihydrochloride hydrate

    An alkaloid with diverse biological activities

     Emetine dihydrochloride hydrate Chemical Structure
  44. GC16044 Emodin Natural CK2 inhibitor and ER agonist Emodin Chemical Structure
  45. GC35982 EN6 An activator of autophagy EN6 Chemical Structure
  46. GC15493 Enalaprilat Dihydrate angiotensin-converting enzyme (ACE) inhibitor Enalaprilat Dihydrate Chemical Structure
  47. GC11625 Entinostat (MS-275,SNDX-275) A histone deacetylase inhibitor Entinostat (MS-275,SNDX-275) Chemical Structure
  48. GC14476 Entrectinib Orally active inhibitor of ALK kinase Entrectinib Chemical Structure
  49. GC11499 Enzastaurin (LY317615) Enzastaurin (LY317615) (LY317615) is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε. Enzastaurin (LY317615) Chemical Structure
  50. GC35998 Episilvestrol Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol Chemical Structure
  51. GC10627 Erlotinib An EGFR tyrosine kinase inhibitor Erlotinib Chemical Structure
  52. GC36003 Erlotinib mesylate EGFR inhibitor Erlotinib mesylate Chemical Structure
  53. GC47303 Erlotinib-d6 (hydrochloride) An internal standard for the quantification of erlotinib Erlotinib-d6 (hydrochloride) Chemical Structure
  54. GC10326 Erythromycin Ethylsuccinate Macrolide antibiotic Erythromycin Ethylsuccinate Chemical Structure
  55. GC14968 Esmolol HCl Esmolol HCl is a beta adrenergic receptor blocker. Esmolol HCl Chemical Structure
  56. GC13022 Esomeprazole Magnesium trihydrate An H+/K+-ATPase inhibitor Esomeprazole Magnesium trihydrate Chemical Structure
  57. GC61669 Ethyl 3,4-dihydroxybenzoate Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate Chemical Structure
  58. GC15617 Etoposide

    Topo II inhibitor

     Etoposide Chemical Structure
  59. GC60826 Etoposide phosphate Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor?to prevent re-ligation of DNA strands. Etoposide phosphate Chemical Structure
  60. GN10511 Eupatilin Eupatilin Chemical Structure
  61. GC13601 Everolimus (RAD001) A rapamycin derivative Everolimus (RAD001) Chemical Structure
  62. GC15605 Ezetimibe Cholesterol transport inhibitor Ezetimibe Chemical Structure
  63. GC60159 Ezetimibe ketone Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe ketone Chemical Structure
  64. GC36023 FAAH inhibitor 1 FAAH inhibitor 1 (Benzothiazole analog 3) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 18±8 nM. FAAH inhibitor 1 Chemical Structure
  65. GC30751 FAAH-IN-1 FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively. FAAH-IN-1 Chemical Structure
  66. GC30366 FAAH-IN-2 FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent FAAH(fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2. FAAH-IN-2 Chemical Structure
  67. GC62203 Falcarindiol Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol Chemical Structure
  68. GC38437 Fangchinoline An alkaloid with diverse biological activities Fangchinoline Chemical Structure
  69. GC13869 Fasudil Calcium antagonist Fasudil Chemical Structure
  70. GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil (HA-1077) HCl is also a potent Ca2+ channel antagonist and vasodilator. Fasudil (HA-1077) HCl Chemical Structure
  71. GC17173 Felodipine Selective L-type Ca2+ channel blocker Felodipine Chemical Structure
  72. GC12250 Fenofibrate

    PPARα agonist

     Fenofibrate Chemical Structure
  73. GC17143 Fenretinide A synthetic retinoic acid derivative Fenretinide Chemical Structure
  74. GC40484 Ferulic Acid methyl ester Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. Ferulic Acid methyl ester Chemical Structure
  75. GC10755 Fexaramine farnesoid X receptor agonist Fexaramine Chemical Structure
  76. GC13620 FIPI

    phosholipase D (PLD) inhibitor

     FIPI Chemical Structure
  77. GC15609 FK 866 hydrochloride NMPRTase inhibitor FK 866 hydrochloride Chemical Structure
  78. GC14308 FK866 (APO866) Inhibitor of nicotinamide phosphoribosyltransferase FK866 (APO866) Chemical Structure
  79. GC16063 Flavopiridol An inhibitor of cyclin-dependent kinases Flavopiridol Chemical Structure
  80. GC16425 Flavopiridol hydrochloride CDK inhibitor, potent and selective Flavopiridol hydrochloride Chemical Structure
  81. GC33848 Fludrocortisone acetate (9α-Fludrocortisone acetate) Fludrocortisone acetate (9α-Fludrocortisone acetate) (9α-Fludrocortisone acetate (9α-Fludrocortisone acetate)) is a synthetic mineralocorticoid, used to control the amount of sodium and fluids in your body. Fludrocortisone acetate (9α-Fludrocortisone acetate) Chemical Structure
  82. GC33715 Fluoxetine (LY-110140)

    Fluoxetine (LY-110140) is an orally active selective serotonin reuptake inhibitor (SSRI). Fluoxetine is a potent inhibitor of the saturated [3H]-5-HT uptake process in rat and human platelets, with IC50 values of 0.10 and 0.05 μM, respectively.

     Fluoxetine (LY-110140) Chemical Structure
  83. GC11709 Fluoxetine HCl Serotonin reuptake inhibitor,selective Fluoxetine HCl Chemical Structure
  84. GC10064 Flurizan A COX-inactive enantiomer of flurbiprofen Flurizan Chemical Structure
  85. GC13535 Fluvastatin An HMG-CoA reductase inhibitor Fluvastatin Chemical Structure
  86. GC36061 Fluvastatin D6 sodium Fluvastatin D6 sodium (XU 62-320 D6) is deuterium labeled Fluvastatin sodium. Fluvastatin D6 sodium Chemical Structure
  87. GC15541 Fluvastatin Sodium An HMG-CoA reductase inhibitor Fluvastatin Sodium Chemical Structure
  88. GC36063 FMK 9a FMK 9a is an autophagin-1 inhibitor with IC50 values of 80 and 73 μM in FRET and LRA assay. FMK 9a Chemical Structure
  89. GC11920 Forskolin Forskolin is a potent adenylyl cyclase activator with IC50 of 41 nM for type I adenylyl cyclase. Forskolin Chemical Structure
  90. GC32411 FR 167653 (FR 167653 sulfate) FR 167653 (FR 167653 sulfate) (FR 167653 (FR 167653 sulfate) sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) Chemical Structure
  91. GC31058 FR 167653 free base FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base Chemical Structure
  92. GC18000 Fulvestrant (ICI 182,780)

    Fulvestrant is a selective estrogen receptor (ER) antagonist. It binds, blocks and degrades ER, then inhibits ER-mediated transcriptional activity with an IC50 of 9.4 nM.

     Fulvestrant (ICI 182,780) Chemical Structure
  93. GN10137 Galangin Galangin Chemical Structure
  94. GC12139 Gambogic Acid A xanthonoid with anticancer activity Gambogic Acid Chemical Structure
  95. GN10109 Ganoderic Acid A Ganoderic Acid A Chemical Structure
  96. GC10359 GANT61 GANT61 was able to efficiently block GLI1 as well as GLI2-induced transcription, IC50 is 5 µM. GANT61 Chemical Structure
  97. GC32739 GCN2iB GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM. GCN2iB Chemical Structure
  98. GC12021 GDC-0349 MTOR inhibitor GDC-0349 Chemical Structure
  99. GC10493 GDC-0449 (Vismodegib) GDC-0449 (Vismodegib) Chemical Structure
  100. GC10816 GDC-0941 A pan inhibitor of class I PI3K isoforms GDC-0941 Chemical Structure
  101. GC16154 GDC-0941 dimethanesulfonate A pan inhibitor of class I PI3K isoforms GDC-0941 dimethanesulfonate Chemical Structure

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