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Autophagy

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. Product Name Information
  2. GC60868 Gefitinib D8 Gefitinib D8 (ZD1839 D8) is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8  Chemical Structure
  3. GC16805 Gemcitabine

    An inhibitor of DNA synthesis

    Gemcitabine  Chemical Structure
  4. GC36130 Gemcitabine elaidate A prodrug form of gemcitabine Gemcitabine elaidate  Chemical Structure
  5. GC14447 Gemcitabine HCl Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. Gemcitabine HCl  Chemical Structure
  6. GN10116 Genipin Genipin  Chemical Structure
  7. GC14102 Genistein

    Genistein is an isoflavone belonging to the flavonoid group of compounds and is found in a number of plants.

    Genistein  Chemical Structure
  8. GN10782 Genistin Genistin  Chemical Structure
  9. GC31717 Ginkgetin A biflavonoid with diverse biological activities Ginkgetin  Chemical Structure
  10. GC36136 Ginkgolide K Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K  Chemical Structure
  11. GN10148 Ginsenoside F2 Ginsenoside F2  Chemical Structure
  12. GN10156 Ginsenoside Rb1 Ginsenoside Rb1  Chemical Structure
  13. GC32998 Ginsenoside Rh4 Ginsenoside Rh4  Chemical Structure
  14. GC33085 Glaucocalyxin B Glaucocalyxin B is an ent kaurane diterpenoid isolated from the Chinese traditional medicine Rabdosia japonica with anticancer and antitumor activity; decreases the growth of HL-60 cells with an IC50 of approximately 5.86 μM at 24 h. Glaucocalyxin B  Chemical Structure
  15. GC12356 Glibenclamide Insulin production modulator Glibenclamide  Chemical Structure
  16. GC19169 GLPG1837 GLPG1837 is a potent and reversible CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. GLPG1837  Chemical Structure
  17. GC36149 GLPG2451 GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM. GLPG2451  Chemical Structure
  18. GC30263 Glucosamine (D-Glucosamine) Glucosamine (D-Glucosamine) (D-Glucosamine (D-Glucosamine)) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine (D-Glucosamine)  Chemical Structure
  19. GN10669 Glucosamine sulfate Glucosamine sulfate  Chemical Structure
  20. GC40911 Glycine-β-muricholic Acid Glycine-β-muricholic Acid, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders. Glycine-β-muricholic Acid  Chemical Structure
  21. GC47408 Glycochenodeoxycholic Acid-d4 A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Glycochenodeoxycholic Acid-d4  Chemical Structure
  22. GC36163 Glycycoumarin Glycycoumarin is a potent antispasmodic agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases. Glycycoumarin  Chemical Structure
  23. GC17804 GlyH-101 CFTR Inhibitor II GlyH-101  Chemical Structure
  24. GC60882 Glyphosate

    An herbicide

    Glyphosate  Chemical Structure
  25. GC41308 GPP 78 Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. GPP 78  Chemical Structure
  26. GC10715 GSK 4112 Rev-Erbα agonist GSK 4112  Chemical Structure
  27. GC15072 GSK2126458 GSK2126458 (GSK2126458) is an orally active and highly selective inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively. GSK2126458 has anti-cancer activity. GSK2126458  Chemical Structure
  28. GC18049 GSK2578215A LRRK2 inhibitor GSK2578215A  Chemical Structure
  29. GC17450 GSK2606414

    A selective PERK inhibitor

    GSK2606414  Chemical Structure
  30. GC11068 GSK2656157 PERK inhibitor GSK2656157  Chemical Structure
  31. GC17534 GSK343 A selective, cell-permeable EZH2 inhibitor GSK343  Chemical Structure
  32. GC13696 GSK690693

    GSK690693 is an ATP-competitive, low nanomolar inhibitor of Akt kinases with IC50 values of 2, 13, and 9 nM for Akt1, 2, and 3, respectively.

    GSK690693  Chemical Structure
  33. GC17658 Guggulsterone Broad spectrum steroid receptor ligand Guggulsterone  Chemical Structure
  34. GC60891 GW406108X GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK. GW406108X  Chemical Structure
  35. GC10975 GW4064

    GW4064, as a synthetic FXR agonist, was used for treatment of cholestatic liver diseases, metabolic syndrome and alcoholic liver disease.

    GW4064  Chemical Structure
  36. GC15318 GW501516 A selective PPARδ-agonist with anti-obesity activity GW501516  Chemical Structure
  37. GC45719 Gymnemic Acid I A triterpene glycoside Gymnemic Acid I  Chemical Structure
  38. GC19396 H 89

    A potent inhibitor of cyclic AMP-dependent protein kinase

    H 89  Chemical Structure
  39. GC10074 H 89 2HCl H 89 2HCl is a potent and selective inhibitor of protein kinase A (PKA) with an IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase. H 89 2HCl  Chemical Structure
  40. GA10942 H-D-Gln-OH H-D-Gln-OH  Chemical Structure
  41. GC19188 HA15 HA15 is a molecule that targets specifically BiP/GRP78/HSPA5. HA15  Chemical Structure
  42. GC14591 Hemin chloride Hemin chloride is an iron-containing porphyrin. Hemin chloride  Chemical Structure
  43. GC10829 Heparin

    injectable anticoagulant

    Heparin  Chemical Structure
  44. GC36215 Heparin Lithium salt Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII). Heparin Lithium salt  Chemical Structure
  45. GC19766 Heparin sodium salt (MW 15kDa)

    A polymer of Heparin with the molecular weight of 15kD

    Heparin sodium salt (MW 15kDa)  Chemical Structure
  46. GC17196 Hesperadin A multi-kinase inhibitor Hesperadin  Chemical Structure
  47. GN10613 Hesperidin Hesperidin  Chemical Structure
  48. GN10248 Hesperitin Hesperitin  Chemical Structure
  49. GC63515 Hoechst 33342

    The nucleic acid stain Hoechst 33342 (Ex/Em: 350/461 nm) is frequently utilized as a cell-permeable nuclear counterstain that emits a blue fluorescence upon binding to dsDNA.

    Hoechst 33342  Chemical Structure
  50. GC10939 Hoechst 33342 trihydrochloride

    The nucleic acid stain Hoechst 33342 trihydrochloride (Ex/Em: 350/461 nm) is frequently utilized as a cell-permeable nuclear counterstain that emits a blue fluorescence upon binding to dsDNA.

    Hoechst 33342 trihydrochloride  Chemical Structure
  51. GN10664 Honokiol Honokiol  Chemical Structure
  52. GC47436 HT-2 Toxin-13C22 An internal standard for the quantification of HT-2 toxin HT-2 Toxin-13C22  Chemical Structure
  53. GC19569 Hydroquinone Hydroquinone  Chemical Structure
  54. GC12544 Hydroxychloroquine Sulfate

    Autophagy inhibitor

    Hydroxychloroquine Sulfate  Chemical Structure
  55. GC47445 Hydroxychloroquine-d4 (sulfate) An internal standard for the quantification of hydroxychloroquine Hydroxychloroquine-d4 (sulfate)  Chemical Structure
  56. GC16843 Hydroxyurea DNA synthesis inhibitor Hydroxyurea  Chemical Structure
  57. GN10278 Icariin

    Icariin is a flavonol glycoside.

    Icariin  Chemical Structure
  58. GC38096 Icaritin Icaritin is a prenylflavonoid derivative obtained from the Epimedium genus. Icaritin  Chemical Structure
  59. GC32762 Icaritin (Anhydroicaritin) Icaritin (Anhydroicaritin) (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium brevicornuMaxim. and potently inhibits proliferation of K562 cells (IC50 of 8 μM) and primary CML cells (IC50 of 13.4 μM for CML-CP and 18 μM for CML-BC). Icaritin (Anhydroicaritin) can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis[3. Icaritin (Anhydroicaritin)  Chemical Structure
  60. GC62626 ICCB-19 hydrochloride ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride  Chemical Structure
  61. GC14969 Idarubicin HCl Idarubicin HCl is an anthracycline antileukemic drug. Idarubicin HCl  Chemical Structure
  62. GC62465 Idelalisib D5 Idelalisib D5 is a deuterium labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor. Idelalisib D5  Chemical Structure
  63. GC19411 IITZ-01 IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. IITZ-01  Chemical Structure
  64. GC10314 Imatinib (STI571) Imatinib (STI571) (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib (STI571) also is an inhibitor of SARS-CoV and MERS-CoV. Imatinib (STI571)  Chemical Structure
  65. GC60930 Imatinib D4 Imatinib D4 (STI571 D4) is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib D4  Chemical Structure
  66. GC39612 Imatinib D8 Imatinib D8 (STI571 D8) is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib D8  Chemical Structure
  67. GC11759 Imatinib Mesylate (STI571) Imatinib Mesylate (STI571) (STI571 Mesylate) is a tyrosine kinases inhibitor that inhibits c-Kit, Bcr-Abl, and PDGFR (IC50=100 nM) tyrosine kinases. Imatinib Mesylate (STI571)  Chemical Structure
  68. GC10712 Imiquimod hydrochloride Toll-like receptor 7 agonist Imiquimod hydrochloride  Chemical Structure
  69. GC12645 Imiquimod maleate Immune response modifier Imiquimod maleate  Chemical Structure
  70. GC49670 Indium (III) thiosemicarbazone 5b An anticancer agent Indium (III) thiosemicarbazone 5b  Chemical Structure
  71. GC17556 Indomethacin

    Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively.

    Indomethacin  Chemical Structure
  72. GC60935 Indomethacin sodium hydrate Indomethacin (Indometacin) sodium hydrateis a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium hydrate  Chemical Structure
  73. GC40227 Indomethacin-d4 Indomethacin-d4 is intended for use as an internal standard for the quantification of indomethacin by GC- or LC-MS. Indomethacin-d4  Chemical Structure
  74. GC61565 Indophagolin Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7. Indophagolin  Chemical Structure
  75. GC10969 INK 128(MLN0128) INK 128 (MLN0128) (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase. INK 128(MLN0128)  Chemical Structure
  76. GC32742 INT-767 INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively. INT-767  Chemical Structure
  77. GC16105 Iohexol contrast agent Iohexol  Chemical Structure
  78. GC11229 IOWH-032 CFTR inhibitor IOWH-032  Chemical Structure
  79. GC30608 Ipsalazide

    Ipsalazide is a novel sulfasalazine analog designed to release 5-aminosalicylic acid and a nontoxic carrier molecule in the gastrointestinal tract.

    Ipsalazide  Chemical Structure
  80. GC11473 Irinotecan Topoisomerase I inhibitor Irinotecan  Chemical Structure
  81. GC11048 Irinotecan HCl Trihydrate Irinotecan HCl Trihydrate ((+)-Irinotecan HCl Trihydrate) is a topoisomerase I inhibitor with antitumor activity. Irinotecan HCl Trihydrate  Chemical Structure
  82. GC36329 Irinotecan hydrochloride Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer. Irinotecan hydrochloride  Chemical Structure
  83. GN10666 Isoalantolactone Isoalantolactone  Chemical Structure
  84. GC13795 Isobavachalcone A chalcone and flavonoid with diverse biological activities Isobavachalcone  Chemical Structure
  85. GC39109 Isodeoxyelephantopin Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer. Isodeoxyelephantopin  Chemical Structure
  86. GN10088 Isoliquiritigenin Isoliquiritigenin  Chemical Structure
  87. GC12017 Isoniazid antibiotic used for the treatment of tuberculosis Isoniazid  Chemical Structure
  88. GC64098 Isoniazid-d4 Isoniazid-d4  Chemical Structure
  89. GC36339 Isorhapontigenin Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin  Chemical Structure
  90. GC15826 Isosorbide Diuretic Isosorbide  Chemical Structure
  91. GC36346 Isosorbide mononitrate A nitric oxide donor with cardioprotective activity Isosorbide mononitrate  Chemical Structure
  92. GC15382 Isotretinoin A retinoid Isotretinoin  Chemical Structure
  93. GC43922 Isovaleryl-L-carnitine (chloride) Isovaleryl-L-carnitine (chloride), a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils. Isovaleryl-L-carnitine (chloride)  Chemical Structure
  94. GC10447 Isradipine (Dynacirc) Isradipine (Dynacirc) (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine (Dynacirc)  Chemical Structure
  95. GC11056 Itraconazole antifungal agent Itraconazole  Chemical Structure
  96. GC32209 ITX5061 ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). ITX5061  Chemical Structure
  97. GC14797 IU1 A deubiquitinating enzyme inhibitor IU1  Chemical Structure
  98. GC10296 Ivacaftor (VX-770) Ivacaftor (VX-770) (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively. Ivacaftor (VX-770)  Chemical Structure
  99. GC12489 Ivacaftor benzenesulfonate A CFTR potentiator Ivacaftor benzenesulfonate  Chemical Structure
  100. GC13316 Ivacaftor hydrate A CFTR potentiator Ivacaftor hydrate  Chemical Structure
  101. GC12339 Ivermectin NAChR/purinergic P2X4 receptor modulator Ivermectin  Chemical Structure

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