Autophagy
Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.
Products for Autophagy
- Cat.No. Product Name Information
- GC60868 Gefitinib D8 Gefitinib D8 (ZD1839 D8) is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells.
-
GC16805
Gemcitabine
An inhibitor of DNA synthesis
- GC36130 Gemcitabine elaidate A prodrug form of gemcitabine
- GC14447 Gemcitabine HCl Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
- GN10116 Genipin
-
GC14102
Genistein
Genistein is an isoflavone belonging to the flavonoid group of compounds and is found in a number of plants.
- GN10782 Genistin
- GC31717 Ginkgetin A biflavonoid with diverse biological activities
- GC36136 Ginkgolide K Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway.
- GN10148 Ginsenoside F2
- GN10156 Ginsenoside Rb1
- GC32998 Ginsenoside Rh4
- GC33085 Glaucocalyxin B Glaucocalyxin B is an ent kaurane diterpenoid isolated from the Chinese traditional medicine Rabdosia japonica with anticancer and antitumor activity; decreases the growth of HL-60 cells with an IC50 of approximately 5.86 μM at 24 h.
- GC12356 Glibenclamide Insulin production modulator
- GC19169 GLPG1837 GLPG1837 is a potent and reversible CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
- GC36149 GLPG2451 GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM.
- GC30263 Glucosamine (D-Glucosamine) Glucosamine (D-Glucosamine) (D-Glucosamine (D-Glucosamine)) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement.
- GN10669 Glucosamine sulfate
- GC40911 Glycine-β-muricholic Acid Glycine-β-muricholic Acid, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders.
- GC47408 Glycochenodeoxycholic Acid-d4 A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
- GC36163 Glycycoumarin Glycycoumarin is a potent antispasmodic agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases.
- GC17804 GlyH-101 CFTR Inhibitor II
-
GC60882
Glyphosate
An herbicide
- GC41308 GPP 78 Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase.
- GC10715 GSK 4112 Rev-Erbα agonist
- GC15072 GSK2126458 GSK2126458 (GSK2126458) is an orally active and highly selective inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively. GSK2126458 has anti-cancer activity.
- GC18049 GSK2578215A LRRK2 inhibitor
-
GC17450
GSK2606414
A selective PERK inhibitor
- GC11068 GSK2656157 PERK inhibitor
- GC17534 GSK343 A selective, cell-permeable EZH2 inhibitor
-
GC13696
GSK690693
GSK690693 is an ATP-competitive, low nanomolar inhibitor of Akt kinases with IC50 values of 2, 13, and 9 nM for Akt1, 2, and 3, respectively.
- GC17658 Guggulsterone Broad spectrum steroid receptor ligand
- GC60891 GW406108X GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK.
-
GC10975
GW4064
GW4064, as a synthetic FXR agonist, was used for treatment of cholestatic liver diseases, metabolic syndrome and alcoholic liver disease.
- GC15318 GW501516 A selective PPARδ-agonist with anti-obesity activity
- GC45719 Gymnemic Acid I A triterpene glycoside
-
GC19396
H 89
A potent inhibitor of cyclic AMP-dependent protein kinase
- GC10074 H 89 2HCl H 89 2HCl is a potent and selective inhibitor of protein kinase A (PKA) with an IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase.
- GA10942 H-D-Gln-OH
- GC19188 HA15 HA15 is a molecule that targets specifically BiP/GRP78/HSPA5.
- GC14591 Hemin chloride Hemin chloride is an iron-containing porphyrin.
-
GC10829
Heparin
injectable anticoagulant
- GC36215 Heparin Lithium salt Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII).
-
GC19766
Heparin sodium salt (MW 15kDa)
A polymer of Heparin with the molecular weight of 15kD
- GC17196 Hesperadin A multi-kinase inhibitor
- GN10613 Hesperidin
- GN10248 Hesperitin
-
GC63515
Hoechst 33342
The nucleic acid stain Hoechst 33342 (Ex/Em: 350/461 nm) is frequently utilized as a cell-permeable nuclear counterstain that emits a blue fluorescence upon binding to dsDNA.
-
GC10939
Hoechst 33342 trihydrochloride
The nucleic acid stain Hoechst 33342 trihydrochloride (Ex/Em: 350/461 nm) is frequently utilized as a cell-permeable nuclear counterstain that emits a blue fluorescence upon binding to dsDNA.
- GN10664 Honokiol
- GC47436 HT-2 Toxin-13C22 An internal standard for the quantification of HT-2 toxin
- GC19569 Hydroquinone
-
GC12544
Hydroxychloroquine Sulfate
Autophagy inhibitor
- GC47445 Hydroxychloroquine-d4 (sulfate) An internal standard for the quantification of hydroxychloroquine
- GC16843 Hydroxyurea DNA synthesis inhibitor
-
GN10278
Icariin
Icariin is a flavonol glycoside.
- GC38096 Icaritin Icaritin is a prenylflavonoid derivative obtained from the Epimedium genus.
- GC32762 Icaritin (Anhydroicaritin) Icaritin (Anhydroicaritin) (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium brevicornuMaxim. and potently inhibits proliferation of K562 cells (IC50 of 8 μM) and primary CML cells (IC50 of 13.4 μM for CML-CP and 18 μM for CML-BC). Icaritin (Anhydroicaritin) can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis[3.
- GC62626 ICCB-19 hydrochloride ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor.
- GC14969 Idarubicin HCl Idarubicin HCl is an anthracycline antileukemic drug.
- GC62465 Idelalisib D5 Idelalisib D5 is a deuterium labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor.
- GC19411 IITZ-01 IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ.
- GC10314 Imatinib (STI571) Imatinib (STI571) (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib (STI571) also is an inhibitor of SARS-CoV and MERS-CoV.
- GC60930 Imatinib D4 Imatinib D4 (STI571 D4) is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity.
- GC39612 Imatinib D8 Imatinib D8 (STI571 D8) is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity.
- GC11759 Imatinib Mesylate (STI571) Imatinib Mesylate (STI571) (STI571 Mesylate) is a tyrosine kinases inhibitor that inhibits c-Kit, Bcr-Abl, and PDGFR (IC50=100 nM) tyrosine kinases.
- GC10712 Imiquimod hydrochloride Toll-like receptor 7 agonist
- GC12645 Imiquimod maleate Immune response modifier
- GC49670 Indium (III) thiosemicarbazone 5b An anticancer agent
-
GC17556
Indomethacin
Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively.
- GC60935 Indomethacin sodium hydrate Indomethacin (Indometacin) sodium hydrateis a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively.
- GC40227 Indomethacin-d4 Indomethacin-d4 is intended for use as an internal standard for the quantification of indomethacin by GC- or LC-MS.
- GC61565 Indophagolin Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7.
- GC10969 INK 128(MLN0128) INK 128 (MLN0128) (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase.
- GC32742 INT-767 INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively.
- GC16105 Iohexol contrast agent
- GC11229 IOWH-032 CFTR inhibitor
-
GC30608
Ipsalazide
Ipsalazide is a novel sulfasalazine analog designed to release 5-aminosalicylic acid and a nontoxic carrier molecule in the gastrointestinal tract.
- GC11473 Irinotecan Topoisomerase I inhibitor
- GC11048 Irinotecan HCl Trihydrate Irinotecan HCl Trihydrate ((+)-Irinotecan HCl Trihydrate) is a topoisomerase I inhibitor with antitumor activity.
- GC36329 Irinotecan hydrochloride Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer.
- GN10666 Isoalantolactone
- GC13795 Isobavachalcone A chalcone and flavonoid with diverse biological activities
- GC39109 Isodeoxyelephantopin Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer.
- GN10088 Isoliquiritigenin
- GC12017 Isoniazid antibiotic used for the treatment of tuberculosis
- GC64098 Isoniazid-d4
- GC36339 Isorhapontigenin Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects.
- GC15826 Isosorbide Diuretic
- GC36346 Isosorbide mononitrate A nitric oxide donor with cardioprotective activity
- GC15382 Isotretinoin A retinoid
- GC43922 Isovaleryl-L-carnitine (chloride) Isovaleryl-L-carnitine (chloride), a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils.
- GC10447 Isradipine (Dynacirc) Isradipine (Dynacirc) (PN 200-110) is an orally active L-type calcium channel blocker.
- GC11056 Itraconazole antifungal agent
- GC32209 ITX5061 ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).
- GC14797 IU1 A deubiquitinating enzyme inhibitor
- GC10296 Ivacaftor (VX-770) Ivacaftor (VX-770) (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.
- GC12489 Ivacaftor benzenesulfonate A CFTR potentiator
- GC13316 Ivacaftor hydrate A CFTR potentiator
- GC12339 Ivermectin NAChR/purinergic P2X4 receptor modulator