DUB
Deubiquitinating enzymes (DUBs), belonging to the superfamily of proteases, are a group of enzymes that catalyze the cleavage of ubiquitin from ubiquitin-linked molecules after the terminal carbonyl of the last residue of ubiquitin (Gly76). Based on the mechanism of catalysis, DUBs is divided into two classes, cysteine proteases, which interact with substrates through the thiol group of a cysteine in the active site, and metalloproteases, which form a noncovalent intermediate with the substrate through a Zn2+ bound polarized water molecule. The cysteine protease DUBs have different Ub-protease domains and hence are further divided into four subclasses, ubiquitin-specific protease (USP), ubiquitin C-terminal hydrolase (UCH), Otubain protease (OTU) and Machado-Joseph disease protease (MJD); while all metalloprotease DUBs have one Ub protease domain called JAMM (JAB1/MPN/Mov34 metalloenzyme).
Products for DUB
- Cat.No. Product Name Information
- GC13892 C527 Inhibitor of USP1/USF1 complex
-
GC17912
C598-0466
USP7 inhibitor
- GC17125 DUBs-IN-2 DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8.
- GC10356 DUBs-IN-3 DUBs-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8.
- GC12622 HBX 41108 Ubiquitin-specific protease (USP) 7 inhibitor
- GC14797 IU1 A deubiquitinating enzyme inhibitor
- GC10510 LDN 57444 An inhibitor of UCH-L1
- GC17635 ML-323 USP1-UAF1 inhibitor
- GC12475 NSC 632839 hydrochloride A deubiquitylase and deSUMOylase inhibitor
- GC10379 P 22077
- GC12067 P005091 A selective inhibitor of ubiquitin-specific protease 7
- GC17698 SJB2-043 An inhibitor of the USP1-UAF1 complex and SARS-CoV-2 PLpro
- GC13401 SJB3-019A Usp1 inhibitor
- GC10601 Ubiquitin Isopeptidase Inhibitor I Ubiquitin Isopeptidase Inhibitor I (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.
-
GC17269
Vialinin A
A natural immunosuppressant from fungi
- GC10970 WP1130 WP1130 (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. WP1130 has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.