Arenavirus

An arenavirus is a virus which is a member of the family Arenaviridae. These viruses infect rodents and occasionally humans.

Arenaviruses are a diverse family of small, enveloped, single-stranded RNA viruses which are generally propagated through asymptomatic, chronic infection of specific rodent hosts. Several arenaviruses are significant human pathogens, including five distinct hemorrhagic fever viruses designated category A by the CDC and NIAID, which is indicative of the level of highest threat to civilian populations. Several arenaviruses, including Lassa virus (LASV), are causative agents of hemorrhagic fever, for which effective therapeutic options are lacking.

The convergence of sensitivity to diverse small-molecule inhibitors thus identifies a robust new target for arenavirus antiviral discovery within the viral entry phase.

Targets for Arenavirus

Products for Arenavirus

Cat.No. Product Name Information
GN10629 5,7-dihydroxychromone
GC34252 GP(33-41)
GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2Db molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM.
GC65488 GP(33-41) TFA GP(33-41) TFA, a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus.
GC69363 LCMV GP (61-80)
LCMV GP (61-80) is a peptide fragment derived from the glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), corresponding to amino acid sequence 61-80. LCMV GP (61-80) is a specific antigenic determinant that can induce CD4+ T cell responses.
GC65001 LHF-535 LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
GC18485 Retro-2

RN 1-001
Retro-2 (RN 1-001) is a dihydroquinazolinone (DHQZ) inhibitor of retrograde trafficking.
GC37681 ST-193 ST-193 is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
GC34375 ST-193 hydrochloride ST-193 hydrochloride is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
GC37751 Tecovirimat