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Home >> Signaling Pathways >> Microbiology & Virology >> Filovirus

Filovirus

Filoviruses is amongst the most lethal of primate pathogens. Filoviruses cause lethal hemorrhagic fever in humans and nonhuman primates. The family Filoviridae includes two genera: Marburgvirus, comprising various strains of the Lake Victoria marburgvirus (MARV); and Ebolavirus (EBOVs), comprising four species including Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Ivory Coast ebolavirus (CIEBOV), and Reston ebolavirus (REBOV); and a tentative species Bundibugyo ebolavirus (BEBOV).

The infections typically affect multiple organs in the body and are often accompanied by hemorrhage (bleeding). Once the virus has been transmitted from an animal host to a human, it can then spread through person-to-person contact.

Targets for  Filovirus

Products for  Filovirus

  1. Cat.No. Product Name Information
  2. GC67627 2'-Deoxy-5'-O-DMT-2'-fluorouridine 2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5'-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity. 2'-Deoxy-5'-O-DMT-2'-fluorouridine Chemical Structure
  3. GC14314 Aloperine An alkaloid Aloperine Chemical Structure
  4. GC72368 Ansuvimab Ansuvimab (Ansuvimab-zyk) is a recombinant human monoclonal IgG1 antibody that exhibits antiviral activity against Zaire ebolavirus. Ansuvimab Chemical Structure
  5. GC72370 Atoltivimab Atoltivimab (REGN3470), or maftivimab/odesivimab (Inmazeb) is the first Food and agent Administration (FDA)-approved monoclonal antibody to target Zaire ebolavirus (EBOVs) infection. Atoltivimab Chemical Structure
  6. GC43228 Cephaeline

    (-)-Cephaeline

     Cephaeline is an alkaloid originally isolated from C. Cephaeline Chemical Structure
  7. GC72446 Cosfroviximab Cosfroviximab (c13C6-FR1) is a mouse/human chimeric monoclonal antibody against Ebola virus glycoprotein (EBOV-GP). Cosfroviximab Chemical Structure
  8. GC72667 EBOV-IN-1 EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 Chemical Structure
  9. GC32092 Galidesivir (BCX 4430) Galidesivir (BCX 4430) (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir (BCX 4430) Chemical Structure
  10. GC32089 Galidesivir hydrochloride (BCX 4430 (hydrochloride)) Galidesivir (BCX4430) hydrochloride, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir hydrochloride (BCX 4430 (hydrochloride)) Chemical Structure
  11. GC72421 Larcaviximab Larcaviximab (c4G7-N) is an IgG1 kappa anti-Ebola virus glycoprotein chimeric monoclonal antibody. Larcaviximab Chemical Structure
  12. GC72425 Maftivimab Maftivimab (REGN3470-3471-3479), the inhibitor of Filovirus, is an Food and agent Administration (FDA)-approved agent. Maftivimab Chemical Structure
  13. GC72434 Odesivimab Odesivimab is a human monoclonal antibody, targeting Ebola virus glycoprotein with a KD value of 7.74 nM for recombinant histidine-tagged Makona strain Ebola virus glycoprotein ectodomain protein. Odesivimab Chemical Structure
  14. GC72436 Porgaviximab Porgaviximab is a monoclonal antibody that can be used Ebola infection research. Porgaviximab Chemical Structure

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