Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
Targets for Fungal
Products for Fungal
- Cat.No. Product Name Information
- GC41501 α-Terpinene α-Terpinene is a terpenoid that has been found in Cannabis and has diverse biological activities, including acaricidal, antiprotozoal, and antioxidant properties.
- GC66340 β-Amyrone β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity.
- GC41503 γ-Terpinene γ-Terpinene is a monoterpene that has been found in various plants, including C.
- GC12404 (+)-Ketoconazole Potent inhibitor of cytochrome P450c17
- GC34950 (-)-Ketoconazole (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole.
- GC34946 (-)-Maackiain (-)-Maackiain is a pterocarpan phytoalexin produced from Red clover (Trifolium pretense L.
- GC62733 (E)-Coniferin (E)-Coniferin is the isomer of Coniferin.
- GC38725 (S,S)-Valifenalate (S,S)-Valifenalate ((S,S)-IR5885) is an acylamino acid fungicide and is used to control a wide range of fungi belonging to the class of Oomycetes.
- GC60428 (Z)-Lanoconazole (Z)-Lanoconazole is the Z configuration of Lanoconazole.
- GC62760 1-Dodecylimidazole 1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity.
- GC35068 1-Monomyristin A monoacylglycerol
- GC30216 10-Undecenoic acid (Undecylenic acid) 10-Undecenoic acid (Undecylenic acid) was used as a starting reagent in the syntheses of Pheromone (11Z)-hexadecenal.
- GC30800 10-Undecenoic acid zinc salt (Zinc undecylenate) 10-Undecenoic acid zinc salt (Zinc undecylenate) is a natural or synthetic fungistatic fatty acid, is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.
- GC32375 2,3-Dimethoxybenzaldehyde (o-Veratraldehyde) 2,3-Dimethoxybenzaldehyde (o-Veratraldehyde) (o-Veratraldehyde) is a benzaldehyde analog, with high antifungal activity (MIC=2.5 mM) 2,3-Dimethoxybenzaldehyde (o-Veratraldehyde) (o-Veratraldehyde) could be used for the synthesis of berberine.
- GC32389 2,4,6-Tribromophenyl caproate 2,4,6-Tribromophenyl caproate (2,4,6-tribromophenyl caproic acid ester) is an anti-fungal agent.
- GC61899 2-Methoxybenzaldehyde 2-Methoxybenzaldehyde (o-Anisaldehyde), isolated from cinnamon essential oil (CEO), exists antibacterial and antifungal activity.
- GC61673 3,5-Di-tert-butylphenol 3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities.
- GC39687 3,5-Dimethoxybenzoic acid 3,5-Dimethoxybenzoic acid, isolated from Melia azedarach L.
- GC32943 3-(Methylthio)propionic acid (3-Methylsulfanylpropionic acid) 3-(Methylthio)propionic acid (3-Methylsulfanylpropionic acid) is an intermediate in the methionine metabolism.
- GC48518 3-Oxobetulin A pentacyclic triterpenoid with diverse biological activities
- GC33976 4',7-Dimethoxyisoflavone (Dimethoxydaidzein) 4',7-Dimethoxyisoflavone (Dimethoxydaidzein) is isolated from the leaves of Albizzia lebbeck, which shows antifungal activity.
- GC33949 4-Chlorosalicylic acid 4-Chlorosalicylic acid is a pharmaceutical intermediate.
- GC61686 4-Isopropylbenzoic acid 4-Isopropylbenzoic acid, an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa.
- GC61678 4-Methylcinnamic acid 4-Methylcinnamic acid, a Cinnamic acid analog, can be used as a intervention catalyst for overcoming antifungal tolerance.
- GC42484 5,6-dihydroxy Indole 5,6-dihydroxy Indole is an intermediate in melanogenesis.
- GC35153 5,7,3',4'-Tetramethoxyflavone 5,7,3',4'-Tetramethoxyflavone, one of the major polymethoxyflavones (PMFs) isolated from M.
- GC42492 5-bromo-5-nitro-1,3-Dioxane 5-bromo-5-nitro-1,3-Dioxane is an antimicrobial compound that is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast.
- GC39589 5-Dehydroepisterol 5-Dehydroepisterol is an episterol derivative and an?intermediate?in?steroid biosynthesis.
- GN10111 5-hydroxymethyl-2-furaldehyde
- GC62533 6-Chloro-7-deazapurine-β-D-riboside Chloro-7-deazapurine-β-D-riboside is a nucleoside derivative and has antifungal activity.
-
GC60034
7-O-Demethyl rapamycin
7-O-Demethyl rapamycin, a derivative of Rapamycin, has antifungal activity and immunosuppressant properties.
- GC35196 7-Prenyloxycoumarin 7-Prenyloxycoumarin (7-O-Prenylumbelliferone) is a secondary metabolite from the endophytic fungus of Annulohypoxylon ilanense.
- GC35232 Acetyllovastatin Acetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against the enzyme acetylcholinesterase with an IC50 of 79 μg/mL.
- GC60566 Aegeline Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast.
- GC32379 Aliconazole Aliconazole is an antifungal imidazole derivative.
- GC35300 Aloin(mixture of A&B) Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera.
- GC35306 alpha-Mangostin alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
- GN10484 Amentoflavone
- GC18131 Aminothiazole Thyroid inhibitor
- GC15052 Amorolfine HCl Amorolfine (Ro 14-4767/002) hydrochloride is a potent anti-fungal agent.
- GC14092 Amphotericin B Amphipathic polyene antibiotic
- GC60047 Amphotericin B methyl ester Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250).
- GC15026 AN-2690 A broad spectrum antifungal agent
- GC32324 AN2718 A broad-spectrum antifungal
-
GC12754
Anidulafungin
Antifungal drug
- GC32219 Antifungal agent 1 Antifungal agent 1 is a potent antifungal agent.
- GC64848 APX2039 APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme.
- GC62290 Ascr#18 Ascr#18, an ascaroside, is a hormone of nematodes.
- GC62854 Aureobasidin A Aureobasidin A (Basifungin), a cyclic depsipetide, is an antifungal antibiotic.
- GC46904 Azoxystrobin A broad-spectrum fungicide
- GC32308 Bactenecin (Bactenecin, bovine) Bactenecin (Bactenecin, bovine) (Bactenecin (Bactenecin, bovine), bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils.
- GC18297 Bafilomycin B1 The bafilomycins are fungal plecomacrolide antibiotics with a 16-membered lactone ring.
- GC39347 Benzimidazole
- GC12797 Benzoic Acid Organic aromatic monocarboxylic acid
- GC65332 Benzoic acid-13C6
- GN10539 Bergenin
- GC17752 Bifonazole imidazole antifungal drug
- GC45391 Bikaverin
- GC25181 Butenafine Butenafine is a synthetic benzylamine antifungal agent.
- GC13207 Butenafine HCl Butenafine HCl (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.
- GC25182 Butoconazole Butoconazole is an imidazole antifungal used in gynecology.
- GC12984 Butoconazole nitrate Antifungal agent
- GC30960 Caerulomycin A (Cerulomycin) Caerulomycin A (Cerulomycin) (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling.
- GC60668 Calcimycin hemimagnesium Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium).
- GC18922 Camalexin Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection.
- GC32147 Carbendazim Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina.
- GC32331 Carboxin (Carboxine) Carboxin (Carboxine) (Carboxin (Carboxine)e) is a systemic agricultural fungicide and seed protectant.
- GC35612 Carvacrol Carvacrol is a monoterpenoid phenol isolated from Thymus mongolicus Ronn.
- GC10303 Caspofungin Acetate Caspofungin (MK-0991) diacetate is a potent antifungal agent.
- GC64117 Caulilexin C Caulilexin C is a phytoalexin from crucifers with antifungal activity.
- GC60100 Cauloside A Cauloside A (Leontoside A) is a saponin isolated from Dipsacus asper roots.
- GC38681 Cedrol A sesquiterpene alcohol
- GC15391 Cercosporamide A potent inhibitor of fungal Pkc1 and mammalian Mnk isoforms
- GC65430 Cerebroside B Cerebroside B, a sphingolipid compound, is a non-racespecific elicitor, which elicits defense responses in rice.
- GC32394 Chlordantoin (Clodantoin) Chlordantoin (Clodantoin) is an antifungal agent and has the potential for vaginal candidiasis treatment.
- GC39601 Chlormidazole hydrochloride Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci.
- GC39358 Chlorobutanol Chlorobutanol is a pharmaceutical preservative.
- GC62358 Chlorobutanol hemihydrate Chlorobutanol hemihydrate is a pharmaceutical preservative.
- GC47082 Chlorothalonil A broad-spectrum organochlorine fungicide
- GC60701 Chlorphenesin Chlorphenesin is a reversible antigen-associated immunosuppressant.
- GC17540 Chlorquinaldol Antifungal and antibacterial
- GC10132 Ciclopirox broad-spectrum antifungal agent
- GC11120 Ciclopirox ethanolamine Ciclopirox ethanolamine (Ciclopirox ethanolamine) is a synthetic antifungal agent that can be used for superficial mycoses reseaech.
- GC16661 Citrinin A mycotoxin inducing apoptosis
- GC65557 Cladosporin Cladosporin is a fungal metabolite produced in good yield in the mycelium of Cladosporium cladosporioid.
- GC11460 Climbazole Broad-spectrum imidazole antifungal agent
- GC32078 Clioquinol (Iodochlorhydroxyquin) Clioquinol (Iodochlorhydroxyquin) (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity.
- GC16804 Clotrimazole antifungal compound
- GC32184 Cloxiquine (5-Chloro-8-quinolinol) Cloxiquine (5-Chloro-8-quinolinol) (5-Chloro-8-quinolinol) is an antibacterial, antifungal and antiamoebic agent.
- GC63892 Colutehydroquinone Colutehydroquinone is an isoflavonoid that can be found in the root bark of Colutea arborescens.
- GC35725 Coniferin Coniferin (Laricin) is a glucoside of coniferyl alcohol.
- GC35726 Coniferyl alcohol A monolignol
- GC64090 Corydalmine Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi.
- GC35732 Corypalmine Corypalmine is an alkaloid from Corydalis chaerophylla.
- GC65545 Cyclo(L-Phe-L-Pro)
-
GC17198
Cycloheximide
Cycloheximide is an antibiotic that inhibits protein synthesis at the translation level, acting exclusively on cytoplasmic (80s) ribosomes of eukaryotes.
- GC45904 Cyclosporin C A fungal metabolite with diverse biological activities
- GC60736 Cymoxanil A cyanoacetamide fungicide
- GC47159 Cyprodinil An anilinopyrimidine fungicide
- GC43358 Cytochalasin A The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.