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Home >> Signaling Pathways >> Microbiology & Virology >> Fungal

Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

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Products for  Fungal

  1. Cat.No. Product Name Information
  2. GC41501 α-Terpinene

    p-Mentha-1,3-diene

     α-Terpinene is a terpenoid that has been found in Cannabis and has diverse biological activities, including acaricidal, antiprotozoal, and antioxidant properties. α-Terpinene Chemical Structure
  3. GC71998 β-Amyrin acetate β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate Chemical Structure
  4. GC66340 β-Amyrone

    β-Amyron

     β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity. β-Amyrone Chemical Structure
  5. GC41503 γ-Terpinene

    NSC 21448

     γ-Terpinene is a monoterpene that has been found in various plants, including C. γ-Terpinene Chemical Structure
  6. GC12404 (+)-Ketoconazole

    R 41400

     Potent inhibitor of cytochrome P450c17 (+)-Ketoconazole Chemical Structure
  7. GC34950 (-)-Ketoconazole

    R 41400

     (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. (-)-Ketoconazole Chemical Structure
  8. GC34946 (-​)​-Maackiain (-)-Maackiain is a pterocarpan phytoalexin produced from Red clover (Trifolium pretense L. (-​)​-Maackiain Chemical Structure
  9. GC70605 (2R,4S)-Hydroxy Itraconazole-d5 (2R,4S)-Hydroxy Itraconazole-d5 is the deuterium labeled (2R,4S)-Hydroxy Itraconazole. (2R,4S)-Hydroxy Itraconazole-d5 Chemical Structure
  10. GC62733 (E)-Coniferin (E)-Coniferin is the isomer of Coniferin. (E)-Coniferin Chemical Structure
  11. GC38725 (S,S)-Valifenalate

    (S,S)-IR5885; (S,S)-Valiphenal

     (S,S)-Valifenalate ((S,S)-IR5885) is an acylamino acid fungicide and is used to control a wide range of fungi belonging to the class of Oomycetes. (S,S)-Valifenalate Chemical Structure
  12. GC60428 (Z)-Lanoconazole (Z)-Lanoconazole is the Z configuration of Lanoconazole. (Z)-Lanoconazole Chemical Structure
  13. GC62760 1-Dodecylimidazole 1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity. 1-Dodecylimidazole Chemical Structure
  14. GC35068 1-Monomyristin

    MG(14:0/0:0/0:0), 1-Monomyristin

     A monoacylglycerol 1-Monomyristin Chemical Structure
  15. GC30216 10-Undecenoic acid (Undecylenic acid) 10-Undecenoic acid (Undecylenic acid) was used as a starting reagent in the syntheses of Pheromone (11Z)-hexadecenal. 10-Undecenoic acid (Undecylenic acid) Chemical Structure
  16. GC30800 10-Undecenoic acid zinc salt (Zinc undecylenate) 10-Undecenoic acid zinc salt (Zinc undecylenate) is a natural or synthetic fungistatic fatty acid, is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions. 10-Undecenoic acid zinc salt (Zinc undecylenate) Chemical Structure
  17. GC32375 2,3-Dimethoxybenzaldehyde (o-Veratraldehyde) 2,3-Dimethoxybenzaldehyde (o-Veratraldehyde) (o-Veratraldehyde) is a benzaldehyde analog, with high antifungal activity (MIC=2.5 mM) 2,3-Dimethoxybenzaldehyde (o-Veratraldehyde) (o-Veratraldehyde) could be used for the synthesis of berberine. 2,3-Dimethoxybenzaldehyde (o-Veratraldehyde) Chemical Structure
  18. GC32389 2,4,6-Tribromophenyl caproate 2,4,6-Tribromophenyl caproate (2,4,6-tribromophenyl caproic acid ester) is an anti-fungal agent. 2,4,6-Tribromophenyl caproate Chemical Structure
  19. GC61899 2-Methoxybenzaldehyde 2-Methoxybenzaldehyde (o-Anisaldehyde), isolated from cinnamon essential oil (CEO), exists antibacterial and antifungal activity. 2-Methoxybenzaldehyde Chemical Structure
  20. GC71551 2-Phenylethyl isothiocyanate-d5 2-Phenylethyl isothiocyanate-d5 isothiocyanate-d5 is the deuterium labeled 2-Phenylethyl isothiocyanate. 2-Phenylethyl isothiocyanate-d5 Chemical Structure
  21. GC61673 3,5-Di-tert-butylphenol 3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities. 3,5-Di-tert-butylphenol Chemical Structure
  22. GC39687 3,5-Dimethoxybenzoic acid 3,5-Dimethoxybenzoic acid, isolated from Melia azedarach L. 3,5-Dimethoxybenzoic acid Chemical Structure
  23. GC32943 3-(Methylthio)propionic acid (3-Methylsulfanylpropionic acid) 3-(Methylthio)propionic acid (3-Methylsulfanylpropionic acid) is an intermediate in the methionine metabolism. 3-(Methylthio)propionic acid (3-Methylsulfanylpropionic acid) Chemical Structure
  24. GC48518 3-Oxobetulin

    Betulone

     A pentacyclic triterpenoid with diverse biological activities 3-Oxobetulin Chemical Structure
  25. GC33976 4',7-Dimethoxyisoflavone (Dimethoxydaidzein) 4',7-Dimethoxyisoflavone (Dimethoxydaidzein) is isolated from the leaves of Albizzia lebbeck, which shows antifungal activity. 4',7-Dimethoxyisoflavone (Dimethoxydaidzein) Chemical Structure
  26. GC33949 4-Chlorosalicylic acid 4-Chlorosalicylic acid is a pharmaceutical intermediate. 4-Chlorosalicylic acid Chemical Structure
  27. GC61686 4-Isopropylbenzoic acid 4-Isopropylbenzoic acid, an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid Chemical Structure
  28. GC61678 4-Methylcinnamic acid 4-Methylcinnamic acid, a Cinnamic acid analog, can be used as a intervention catalyst for overcoming antifungal tolerance. 4-Methylcinnamic acid Chemical Structure
  29. GC42484 5,6-dihydroxy Indole

    Dopamine lutine

     5,6-dihydroxy Indole is an intermediate in melanogenesis. 5,6-dihydroxy Indole Chemical Structure
  30. GC35153 5,7,3',4'-Tetramethoxyflavone 5,7,3',4'-Tetramethoxyflavone, one of the major polymethoxyflavones (PMFs) isolated from M. 5,7,3',4'-Tetramethoxyflavone Chemical Structure
  31. GC42492 5-bromo-5-nitro-1,3-Dioxane

    Bronidox

     5-bromo-5-nitro-1,3-Dioxane is an antimicrobial compound that is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast. 5-bromo-5-nitro-1,3-Dioxane Chemical Structure
  32. GC39589 5-Dehydroepisterol 5-Dehydroepisterol is an episterol derivative and an?intermediate?in?steroid biosynthesis. 5-Dehydroepisterol Chemical Structure
  33. GC72057 5-Geranoxy-7-methoxycoumarin 5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and antibacterialactivities. 5-Geranoxy-7-methoxycoumarin Chemical Structure
  34. GN10111 5-hydroxymethyl-2-furaldehyde

    NSC 40738

     5-hydroxymethyl-2-furaldehyde Chemical Structure
  35. GC62533 6-Chloro-7-deazapurine-β-D-riboside Chloro-7-deazapurine-β-D-riboside is a nucleoside derivative and has antifungal activity. 6-Chloro-7-deazapurine-β-D-riboside Chemical Structure
  36. GC60034 7-O-Demethyl rapamycin

    7-O-Demethyl rapamycin, a derivative of Rapamycin, has antifungal activity and immunosuppressant properties.

     7-O-Demethyl rapamycin Chemical Structure
  37. GC35196 7-Prenyloxycoumarin 7-Prenyloxycoumarin (7-O-Prenylumbelliferone) is a secondary metabolite from the endophytic fungus of Annulohypoxylon ilanense. 7-Prenyloxycoumarin Chemical Structure
  38. GC35232 Acetyllovastatin Acetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against the enzyme acetylcholinesterase with an IC50 of 79 μg/mL. Acetyllovastatin Chemical Structure
  39. GC60566 Aegeline Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline Chemical Structure
  40. GC32379 Aliconazole Aliconazole is an antifungal imidazole derivative. Aliconazole Chemical Structure
  41. GC35300 Aloin(mixture of A&B) Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin(mixture of A&B) Chemical Structure
  42. GC35306 alpha-Mangostin alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. alpha-Mangostin Chemical Structure
  43. GC74707 Alternariol, methyl ether Alternariol, metl ether is a common mycotoxin found in spoiled grains and is mutagenic and carcinogenic in vitro. Alternariol, methyl ether Chemical Structure
  44. GN10484 Amentoflavone

    Didemethyl Ginkgetin, NSC 295677

     Amentoflavone Chemical Structure
  45. GC18131 Aminothiazole Thyroid inhibitor Aminothiazole Chemical Structure
  46. GC15052 Amorolfine HCl

    Ro 14-4767/002

     Amorolfine (Ro 14-4767/002) hydrochloride is a potent anti-fungal agent. Amorolfine HCl Chemical Structure
  47. GC14092 Amphotericin B

    LNSAmB, NSC 527017

     Amphipathic polyene antibiotic Amphotericin B Chemical Structure
  48. GC60047 Amphotericin B methyl ester

    LNS-AmB methyl ester

     Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester Chemical Structure
  49. GC15026 AN-2690

    Tavaborole

     A broad spectrum antifungal agent AN-2690 Chemical Structure
  50. GC32324 AN2718 A broad-spectrum antifungal AN2718 Chemical Structure
  51. GC12754 Anidulafungin

    LY303366, VER-002

    Antifungal drug

     Anidulafungin Chemical Structure
  52. GC68660 Anisocoumarin H

    Anisocoumarin H is a coumarin compound with antifungal activity. Anisocoumarin H has shown activity against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MIC values of 62.5 µg/mL.

     Anisocoumarin H Chemical Structure
  53. GC71202 Antibacterial agent 131 Antibacterial agent 131 is a quinoline derivative. Antibacterial agent 131 Chemical Structure
  54. GC32219 Antifungal agent 1 Antifungal agent 1 is a potent antifungal agent. Antifungal agent 1 Chemical Structure
  55. GC71238 Antifungal agent 48 Antifungal agent 48 (Example 308) is an antifungal agent. Antifungal agent 48 Chemical Structure
  56. GC71239 Antifungal agent 49 Antifungal agent 49 (Example 112) is an antifungal agent. Antifungal agent 49 Chemical Structure
  57. GC64848 APX2039 APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 Chemical Structure
  58. GC62290 Ascr#18 Ascr#18, an ascaroside, is a hormone of nematodes. Ascr#18 Chemical Structure
  59. GC62854 Aureobasidin A Aureobasidin A is an orally active cyclic peptide antibiotic. Aureobasidin A is an inhibitor of inositol phosphorylating ceramide synthase AUR1. Aureobasidin A Chemical Structure
  60. GC46904 Azoxystrobin

    ICI-A 5504

     A broad-spectrum fungicide Azoxystrobin Chemical Structure
  61. GC32308 Bactenecin (Bactenecin, bovine) Bactenecin (Bactenecin, bovine) (Bactenecin (Bactenecin, bovine), bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin (Bactenecin, bovine) Chemical Structure
  62. GC18297 Bafilomycin B1

    Setamycin

     The bafilomycins are fungal plecomacrolide antibiotics with a 16-membered lactone ring. Bafilomycin B1 Chemical Structure
  63. GC39347 Benzimidazole Benzimidazole Chemical Structure
  64. GC12797 Benzoic Acid Organic aromatic monocarboxylic acid Benzoic Acid Chemical Structure
  65. GC65332 Benzoic acid-13C6 Benzoic acid-13C6 Chemical Structure
  66. GN10539 Bergenin

    (-)-Bergenin, Cuscutin, NSC 661749

     Bergenin Chemical Structure
  67. GC17752 Bifonazole

    BAY-h 4502, (±)-Bifonazole

     imidazole antifungal drug Bifonazole Chemical Structure
  68. GC45391 Bikaverin

    Lycopersin, NSC 215139

       Bikaverin Chemical Structure
  69. GC25181 Butenafine Butenafine is a synthetic benzylamine antifungal agent. Butenafine Chemical Structure
  70. GC13207 Butenafine HCl Butenafine HCl (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase. Butenafine HCl Chemical Structure
  71. GC25182 Butoconazole Butoconazole is an imidazole antifungal used in gynecology. Butoconazole Chemical Structure
  72. GC12984 Butoconazole nitrate

    (±)-Butoconazole, RS-35887

     Antifungal agent Butoconazole nitrate Chemical Structure
  73. GC30960 Caerulomycin A (Cerulomycin) Caerulomycin A (Cerulomycin) (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Caerulomycin A (Cerulomycin) Chemical Structure
  74. GC60668 Calcimycin hemimagnesium Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium Chemical Structure
  75. GC18922 Camalexin Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection. Camalexin Chemical Structure
  76. GC32147 Carbendazim

    A-118, NSC 109874, U-32104

     Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina. Carbendazim Chemical Structure
  77. GC32331 Carboxin (Carboxine) Carboxin (Carboxine) (Carboxin (Carboxine)e) is a systemic agricultural fungicide and seed protectant. Carboxin (Carboxine) Chemical Structure
  78. GC35612 Carvacrol

    Cymophenol, Isopropyl o-cresol, NSC 6188, p-Cymen-2-ol

     Carvacrol is a monoterpenoid phenol isolated from Thymus mongolicus Ronn. Carvacrol Chemical Structure
  79. GC10303 Caspofungin Acetate

    L743,872, MK 0991

     Caspofungin Acetate, a member of echinocandins, is a lipopeptide anti-fungal compound targeting Aspergillus and Candida by inhibiting β(1,3)-D-Glucan synthase of the fungal cell wall Caspofungin Acetate Chemical Structure
  80. GC64117 Caulilexin C Caulilexin C is a phytoalexin from crucifers with antifungal activity. Caulilexin C Chemical Structure
  81. GC60100 Cauloside A Cauloside A (Leontoside A) is a saponin isolated from Dipsacus asper roots. Cauloside A Chemical Structure
  82. GC38681 Cedrol

    α-Cedrol

     A sesquiterpene alcohol Cedrol Chemical Structure
  83. GC15391 Cercosporamide

    (-)-Cercosporamide

    A potent inhibitor of fungal Pkc1 and mammalian Mnk isoforms

     Cercosporamide Chemical Structure
  84. GC65430 Cerebroside B Cerebroside B, a sphingolipid compound, is a non-racespecific elicitor, which elicits defense responses in rice. Cerebroside B Chemical Structure
  85. GC68860 Chitin synthase inhibitor 4

    Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase (CHS) inhibitor with fungicidal properties. Chitin synthase inhibitor 4 is a potential CHS-based agricultural fungicide.

     Chitin synthase inhibitor 4 Chemical Structure
  86. GC32394 Chlordantoin (Clodantoin) Chlordantoin (Clodantoin) is an antifungal agent and has the potential for vaginal candidiasis treatment. Chlordantoin (Clodantoin) Chemical Structure
  87. GC39601 Chlormidazole hydrochloride

    Clomidazole hydrochloride

     Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci. Chlormidazole hydrochloride Chemical Structure
  88. GC39358 Chlorobutanol Chlorobutanol is a pharmaceutical preservative. Chlorobutanol Chemical Structure
  89. GC62358 Chlorobutanol hemihydrate Chlorobutanol hemihydrate is a pharmaceutical preservative. Chlorobutanol hemihydrate Chemical Structure
  90. GC47082 Chlorothalonil

    2,4,5,6-Tetrachloroisophthalonitrile

     A broad-spectrum organochlorine fungicide Chlorothalonil Chemical Structure
  91. GC60701 Chlorphenesin

    (±)-p-Chlorphenesin, NSC 6401

     Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin Chemical Structure
  92. GC17540 Chlorquinaldol Antifungal and antibacterial Chlorquinaldol Chemical Structure
  93. GC10132 Ciclopirox

    HOE 296b

     broad-spectrum antifungal agent Ciclopirox Chemical Structure
  94. GC11120 Ciclopirox ethanolamine Ciclopirox ethanolamine (Ciclopirox ethanolamine) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox ethanolamine Chemical Structure
  95. GC16661 Citrinin

    NSC 186

     Citrinin is a mycotoxin with multiple biological activities produced by several fungal strains of the genera Penicillium, Aspergillus, and Monascus. Citrinin Chemical Structure
  96. GC65557 Cladosporin Cladosporin is a fungal metabolite produced in good yield in the mycelium of Cladosporium cladosporioid. Cladosporin Chemical Structure
  97. GC11460 Climbazole

    BAY-e 6975

     Broad-spectrum imidazole antifungal agent Climbazole Chemical Structure
  98. GC32078 Clioquinol (Iodochlorhydroxyquin)

    Iodochlorohydroxyquin, NSC 3531, NSC 74938

     Clioquinol (Iodochlorhydroxyquin) (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol (Iodochlorhydroxyquin) Chemical Structure
  99. GC16804 Clotrimazole

    BAYB5087, NSC 257473

     antifungal compound Clotrimazole Chemical Structure
  100. GC32184 Cloxiquine (5-Chloro-8-quinolinol) Cloxiquine (5-Chloro-8-quinolinol) (5-Chloro-8-quinolinol) is an antibacterial, antifungal and antiamoebic agent. Cloxiquine (5-Chloro-8-quinolinol) Chemical Structure
  101. GC63892 Colutehydroquinone Colutehydroquinone is an isoflavonoid that can be found in the root bark of Colutea arborescens. Colutehydroquinone Chemical Structure

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