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Home >> Signaling Pathways >> Microbiology & Virology >> Fungal

Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Targets for  Fungal

Products for  Fungal

  1. Cat.No. Product Name Information
  2. GC43358 Cytochalasin A The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. Cytochalasin A Chemical Structure
  3. GC15211 Damnacanthal p56lck tyrosine kinase inhibitor Damnacanthal Chemical Structure
  4. GC33957 Dehydroacetic acid (Biocide 470F) Dehydroacetic acid (Biocide 470F) (Biocide 470F), a pyrone derivative acts as an antibacterial and antifungal agent. Dehydroacetic acid (Biocide 470F) Chemical Structure
  5. GC39371 Demethoxyencecalin Demethoxyencecalin is a chromene isolated from Helianthus annuus, has antifungal activities. Demethoxyencecalin Chemical Structure
  6. GC60130 Deoxylapachol Deoxylapachol is a major cytotoxic component of New Zealand brown alga, Landsburgia quercifolia. Deoxylapachol Chemical Structure
  7. GC32347 Dermaseptin Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against?bacteria,?fungi, and protozoa?at micromolar concentration. Dermaseptin Chemical Structure
  8. GC60131 Dermaseptin TFA Dermaseptin TFA, a peptide isolated from frog skin, exhibits potent antimicrobial activity against?bacteria,?fungi, and?protozoa?at micromolar concentration. Dermaseptin TFA Chemical Structure
  9. GC43439 Diallyl Trisulfide Hydrogen sulfide (H2S) is an endogenously-produced gaseous second messenger that can regulate many physiological processes. Diallyl Trisulfide Chemical Structure
  10. GN10751 Dictamnine Dictamnine Chemical Structure
  11. GC47217 Difenoconazole A triazole fungicide Difenoconazole Chemical Structure
  12. GC48491 Diflucortolone 21-valerate Diflucortolone 21-valerate is a powerful corticosteroid used topically for the research of various skin diseases. Diflucortolone 21-valerate Chemical Structure
  13. GC33941 Dihydrochelerythrine (12,13-Dihydrochelerythrine) Dihydrochelerythrine (12,13-Dihydrochelerythrine) is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal activity. Dihydrochelerythrine (12,13-Dihydrochelerythrine) Chemical Structure
  14. GC33965 Dihydrosanguinarine (13,14-Dihydrosanguinarine) Dihydrosanguinarine (13,14-Dihydrosanguinarine) is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal and anticancer activity. Dihydrosanguinarine (13,14-Dihydrosanguinarine) Chemical Structure
  15. GC60138 DIMBOA

    DIMBOA (2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one) is a benzoxazinoid (BX), is a secondary metabolite in grasses .

     DIMBOA Chemical Structure
  16. GC47231 Dimethomorph A morpholine fungicide Dimethomorph Chemical Structure
  17. GC17087 Dyclonine HCl Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine HCl Chemical Structure
  18. GC38908 E1210 E1210 is a first-in-class, broad-spectrum and orally active antifungal. E1210 Chemical Structure
  19. GC64327 Eberconazole nitrate Eberconazole nitrate is a dichlorinated imidazole derivative with antifungal activity. Eberconazole nitrate Chemical Structure
  20. GC32275 Econazole ((±)-Econazol) Econazole ((±)-Econazol) is an antifungal compound of the imidazole class. Econazole ((±)-Econazol) Chemical Structure
  21. GC13629 Econazole nitrate Calcium channel inhibitor Econazole nitrate Chemical Structure
  22. GC17554 Efinaconazole novel triazole antifungal drug Efinaconazole Chemical Structure
  23. GC60802 Eleutherol Eleutherol is a naphthalene isolated from E. Eleutherol Chemical Structure
  24. GC61518 Enfumafungin Enfumafungin, a triterpene glycoside, is isolated from extracts derived from an endophytic species of Hormonema. Enfumafungin Chemical Structure
  25. GC14825 Ethacridine lactate monohydrate Antiseptic agent Ethacridine lactate monohydrate Chemical Structure
  26. GC62151 Ethyl Vanillate Ethyl Vanillate is a fungicidal agent. Ethyl Vanillate Chemical Structure
  27. GC36018 Exalamide Exalamide (2-(Hexyloxy)benzamide), an arenecarboxamide, is a potent antifungal agent. Exalamide Chemical Structure
  28. GC34583 Faltan Faltan is a dicarboximide fungicide, widely used on vines and several vegetable crops, and is also cytotoxic effect on human bronchial epithelial cells. Faltan Chemical Structure
  29. GC61441 Famoxadone A fungicide Famoxadone Chemical Structure
  30. GC62503 Fengycin Fengycin is a cyclic lipopeptide used as an agricultural fungicide. Fengycin Chemical Structure
  31. GC10625 Fenticonazole Nitrate Antifungal drug Fenticonazole Nitrate Chemical Structure
  32. GC60841 Filastatin Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin Chemical Structure
  33. GC18406 Filipin Complex Filipin complex is a neutral polyene,it has antifungal activity. Filipin Complex Chemical Structure
  34. GC12048 Filipin III

    Fluorescing antibiotic used for the detection of lipoproteins

     Filipin III Chemical Structure
  35. GC32346 Fluazinam Fluazinam is a broad spectrum pyridinamine fungal inhibitor. Fluazinam Chemical Structure
  36. GC11512 Fluconazole Triazole antifungal agent Fluconazole Chemical Structure
  37. GC17883 Fluconazole hydrate Triazole antifungal drug Fluconazole hydrate Chemical Structure
  38. GC36057 Fluconazole mesylate Fluconazole (mesylate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. Fluconazole mesylate Chemical Structure
  39. GC13753 Flucytosine Antifungal drug Flucytosine Chemical Structure
  40. GC32386 Fludazonium chloride (R23633) Fludazonium chloride (R23633) (R23633) is an anti-fungal agent, which can be used in the treatment and prevention of superficial and systemic fungal infections. Fludazonium chloride (R23633) Chemical Structure
  41. GC36059 Flumorph Flumorph(SYP-L190) is a carboxylic acid amide (CAA) fungicide. Flumorph Chemical Structure
  42. GC34587 Fluopyram Fluopyram is a succinate dehydrogenase inhibitor fungicide, inhibits the growth of F. Fluopyram Chemical Structure
  43. GC63668 Flusilazole Flusilazole (DPX-H6573), an organosilane fungicide, has broad-spectrum antifungal effect. Flusilazole Chemical Structure
  44. GC63907 Flutrimazole Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole Chemical Structure
  45. GC66003 Fluxapyroxad Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. It works by inhibiting succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species. Fluxapyroxad Chemical Structure
  46. GC39711 Fosetyl-aluminum Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum Chemical Structure
  47. GC33924 Fosfluconazole Fosfluconazole is a prodrug of Fluconazole that is widely used as an antifungal agent. Fosfluconazole Chemical Structure
  48. GC33996 Fosravuconazole (BMS-379224) Fosravuconazole (BMS-379224) (BMS-379224), a prodrug of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole (BMS-379224) Chemical Structure
  49. GC62323 Fosravuconazole L-lysine ethanolate Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate), a prodrug of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole L-lysine ethanolate Chemical Structure
  50. GC64321 FR179642 FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin. FR179642 Chemical Structure
  51. GC38685 Geraniol A terpene alcohol with diverse biological activities Geraniol Chemical Structure
  52. GC40261 Germacrene D

    Germacrene D is a major volatile component of Bursera species and a precursor in sesquiterpene biosynthesis in a variety of plants, including Solidago species.

     Germacrene D Chemical Structure
  53. GC13484 Griseofulvin Microtubule associated inhibitor Griseofulvin Chemical Structure
  54. GC38428 Hecogenin A steroid sapogenin with diverse biological activities Hecogenin Chemical Structure
  55. GC61680 Heneicosane Heneicosane is an aroma component isolated from Streptomyces philanthi RL-1-178 or Serapias cordigera. Heneicosane Chemical Structure
  56. GC33479 Hexaconazole ((-)-Hexaconazol) Hexaconazole ((-)-Hexaconazol) is a systemic fungicide used for the control of many fungi particularly Ascomycetes and Basidiomycetes. Hexaconazole ((-)-Hexaconazol) Chemical Structure
  57. GC33958 Hexetidine (NSC-17764) Hexetidine (NSC-17764)is an orally active antiseptic with broad antibacterial and antifungal activity. Hexetidine (NSC-17764) Chemical Structure
  58. GC33438 Hydroxy Itraconazole Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent. Hydroxy Itraconazole Chemical Structure
  59. GC36276 Hydroxy Itraconazole D8 Hydroxy Itraconazole D8 Chemical Structure
  60. GC33991 Hydroxyphenyllactic acid Hydroxyphenyllactic acid is an antifungal metabolite. Hydroxyphenyllactic acid Chemical Structure
  61. GC43882 Hygrolidin Hygrolidin is a macrocyclic lactone originally isolated from S. Hygrolidin Chemical Structure
  62. GC15496 Hygromycin B

    Hygromycin B is an aminoglycoside antibiotic produced by Streptomyces hygroscopicus. 

     Hygromycin B Chemical Structure
  63. GC38430 Hyperoside Hyperoside Chemical Structure
  64. GC32111 Imazalil (Enilconazole) Imazalil (Enilconazole) (Enilconazole) is a fungicide, widely used in agriculture, particularly in the growing of citrus fruits, also used in veterinary medicine as a topical antimycotic. Imazalil (Enilconazole) Chemical Structure
  65. GC60202 Inz-1 Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 Chemical Structure
  66. GC60936 Inz-5 Inz-5 is a fungal-selective mitochondrial cytochrome bc1 inhibitor. Inz-5 Chemical Structure
  67. GC61440 Iprodione Iprodione, a dicarboximide fungicide, has a highly specific action, with a capacity to cause oxidative damage through production of free oxygen radicals (ROS). Iprodione Chemical Structure
  68. GC16707 Isavuconazole triazole antifungal drug Isavuconazole Chemical Structure
  69. GC43911 Isavuconazonium (sulfate) Isavuconazonium is a water-soluble prodrug form of the azole antifungal isavuconazole (ISA). Isavuconazonium (sulfate) Chemical Structure
  70. GC16685 Isoconazole nitrate azole antifungal reagent Isoconazole nitrate Chemical Structure
  71. GC60944 Isoeleutherin Isoeleutherin is a naphthopyran derivative isolated from E. Isoeleutherin Chemical Structure
  72. GN10495 Isoliquiritin Isoliquiritin Chemical Structure
  73. GC63025 Isoprothiolane Isoprothiolane is a systemic fungicide. Isoprothiolane Chemical Structure
  74. GC11056 Itraconazole antifungal agent Itraconazole Chemical Structure
  75. GC65075 Iturin A IturinA exhibits strong antifungal activity against pathogenic yeast and fungi. Iturin A Chemical Structure
  76. GC39001 Kakuol Kakuol is a natural compound with antifungal activity. Kakuol Chemical Structure
  77. GC14432 Kanosamine (hydrochloride) antibiotic Kanosamine (hydrochloride) Chemical Structure
  78. GC36384 Kanzonol C Kanzonol C, a flavonoid isolated from the twigs of Dorstenia barteri (Moraceae), has potential to treat bacterial and fungal infections. Kanzonol C Chemical Structure
  79. GC17337 Ketoconazole A triazole antifungal agent Ketoconazole Chemical Structure
  80. GC47531 Kresoxim-methyl A fungicide Kresoxim-methyl Chemical Structure
  81. GC32355 L-4-Oxalysine hydrochloride L-4-Oxalysine hydrochloride is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China which has shown antitumor activities. L-4-Oxalysine hydrochloride Chemical Structure
  82. GC60980 L-Diguluronic acid L-Diguluronic acid is a linear polysaccharide?copolymer composed of two L-guluronic acid (G) and can be used to from Alginate. L-Diguluronic acid Chemical Structure
  83. GC61011 L-Triguluronic acid L-Triguluronic acid is a linear polysaccharide?copolymer composed of three L-guluronic acid (G) and can be used to from Alginate. L-Triguluronic acid Chemical Structure
  84. GC60221 Lactoferrin (17-41) (acetate) Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin (17-41) (acetate) Chemical Structure
  85. GC60974 Lanoconazole Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi?in vitro?and?in vivo. Lanoconazole Chemical Structure
  86. GC39123 Lapachol A naphthoquinone with diverse biological activities Lapachol Chemical Structure
  87. GC17006 Latrunculin B F-actin–destabilizing agent Latrunculin B Chemical Structure
  88. GC39027 Lawsone Lawsone is a naphthoquinone dye isolated from leaves of Lawsonia inermis that shows antimicrobial and antioxidant activity. Lawsone Chemical Structure
  89. GC63825 Lawsone methyl ether Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. Lawsone methyl ether Chemical Structure
  90. GC10954 Leptomycin B Leptomycin B (LMB) is an inhibitor of chromosome region maintenance 1 (CRM1) that is one of the nuclear protein exporters. Leptomycin B Chemical Structure
  91. GC60226 Lipoxamycin hemisulfate Lipoxamycin hemisulfate is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM. Lipoxamycin hemisulfate Chemical Structure
  92. GC16121 Liranaftate Squalene epoxidase inhibitor Liranaftate Chemical Structure
  93. GC69404 lsocryptomerin

    Isocryptomerin is a membrane-active antifungal compound that can be isolated from Selaginella tamariscina. Isocryptomerin can depolarize the fungal plasma membrane. It also has anticancer and antibacterial activities.

     lsocryptomerin Chemical Structure
  94. GC15397 Luliconazole An imidazole antifungal agent Luliconazole Chemical Structure
  95. GC32312 Magainin 1 Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 Chemical Structure
  96. GC30830 Magainin 2 Magainin 2 (Magainin II) is an?antimicrobial?peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 Chemical Structure
  97. GC64736 Magnesium silicate Magnesium silicate (Activated magnesium silicate) is a compound of magnesium oxide (MgO) and silicon dioxide (SiO2). Magnesium silicate Chemical Structure
  98. GC41370 Magnoflorine Magnoflorine is an alkaloid and a major constituent of S. Magnoflorine Chemical Structure
  99. GC34658 Mancozeb

    Mancozeb is an ethylene-bis-dithiocarbamate fungicide.

     Mancozeb Chemical Structure
  100. GC62398 ME1111 ME1111 is an antifungal agent that is active against dermatophytes. ME1111 Chemical Structure
  101. GC47632 Metalaxyl A fungicide Metalaxyl Chemical Structure

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