Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
Targets for Fungal
Products for Fungal
- Cat.No. Product Name Information
- GC61670 Methyl p-coumarate Methyl p-coumarate (Methyl 4-hydroxycinnamate), an esterified derivative of p-Coumaric acid (pCA), is isolated from the flower of Trixis michuacana var longifolia.
- GC32244 Micafungin (FK463) Micafungin (FK463) (Mycamine; FK463) is an echinocandin antifungal drug which can inhibit 1,3-beta-D-glucan synthase.
- GC17507 Micafungin sodium An echinocandin antifungal
- GC10541 Miconazole imidazole antifungal agent
- GC17493 Miconazole Nitrate Antifungal agent
- GC15592 Moniliformin (sodium salt) induces mitotic arrest at the metaphase stage
- GC38164 Multifungin
- GC30867 Myclobutanil An Analytical Reference Standard
- GC64165 N-Decyl-N,N-dimethyldecan-1-aminium chloride N-Decyl-N,N-dimethyldecan-1-aminium chloride (Didecyldimethylammonium chloride) is a dialkyl-quaternary ammonium compound that is used in numerous products for its bactericidal, virucidal and fungicidal properties.
- GC11363 Naftifine HCl Naftifine HCl is an antibiotic.
-
GC12381
Natamycin
Antifungal macrolide polyene
- GC40669 Nerol Nerol is a monoterpene and isomer of geraniol that has been found in a variety of plants, including Cannabis.
- GC41343 Nerolidol Nerolidol is a sesquiterpene found in a variety of plants, including C.
- GC39408 Neticonazole Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent.
- GC39409 Neticonazole hydrochloride Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent.
- GC13793 NH125 Selective eEF-2 kinase inhibitor
- GC62709 Nikkomycin Z Nikkomycin Z, a nucleoside-peptide, is a selective competitive chitin synthesis inhibitor.
- GC46185 Nimbin A limonoid with diverse biological activities
- GC13632 Nourseothricin (sulfate) broad-spectrum antibiotic
- GC10090 Nystatin (Fungicidin) Nystatin (Fungicidin) is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma.
- GC67746 o-Vanillin
- GC44485 Ochratoxin C Ochratoxin C is the ethyl ester analog of ochratoxin A, a mycotoxin produced by A.
- GC16221 Oligomycin C mitochondrial F1FO-ATP synthase inhibitor
- GC15233 Ophiobolin B calmodulin antagonist
- GC36822 Oteseconazole Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM), shows no obvious effect on human CYP51.
- GC17528 Oxiconazole (nitrate) antifungal imidazole
- GC47854 Paclobutrazol A plant growth retardant
- GC47871 Papyracillic Acid A fungal metabolite
- GC61453 Penconazole Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew.
- GC10120 Phenothiazine Dopamine-2 (D2) receptor antagonist
- GC62158 Picoxystrobin Picoxystrobin is a primary strobilurin fungicide that is widely applied for plant disease control.
- GC61185 Picropodophyllone Picropodophyllone, an aryltetralin lignan, is isolated from leaves of Podophyllum hexandrum, and has antifungal activities.
- GC32203 Piroctone olamine (Piroctone ethanolamine) Piroctone olamine (Piroctone ethanolamine) is a pyridine derivate.
- GC13964 Pneumocandin B0 potent antifungal and inhibitor of ?-(1,3)-D-glucan synthesis
- GC17614 Posaconazole Sterol C14ɑ demethylase inhibitor
-
GC11816
Posaconazole hydrate
C14ɑ demethylase inhibitor
- GC61204 Posaconazole-D4 Posaconazole-D4 is a deuterium-labeled form of Posaconazole.
- GC36950 Posaconazole-D5 Posaconazole-D5 is a deuterium-labeled form of Posaconazole.
- GC25778 Potassium 1-Naphthaleneacetate Potassium 1-Naphthaleneacetate (KANU, α-Naphthaleneacetic Acid Potassium Salt) is being studied as a synthetic growth factor that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viability of certain fungal plant pathogens.
- GC64737 Potassium sorbate Potassium sorbate (Sorbic acid potassium) is a highly efficient, and nonpoisonous?food preservatives.
- GC38218 Proanthocyanidins A polyphenol with antioxidant activity
- GC32676 Proanthocyanidins A polyphenol with antioxidant activity
- GC44686 Prochloraz Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.
- GC44690 Prodigiosin Prodigiosin is a natural red bacterial pigment that has antibiotic, antitumor, and immunosuppressant properties.
- GC65066 Prodigiosin hydrochloride Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite.
- GC47977 Propiconazole A broad-spectrum triazole fungicide
- GC32248 Propoxur A carbamate insecticide
-
GC69770
Protoneogracillin
Protoneogracillin is a furostanol glycoside with activity in inhibiting the plant pathogenic fungus P.oryzae (MMDC=94.0 μM) and cytotoxicity against K562 cancer cells (IC50=6.6 μM).
- GN10180 Pseudolaric acid A
- GN10361 Pseudolaric Acid B
- GN10322 Pseudolaric Acid C
- GC44777 Purpurin Purpurin is a naturally occurring reddish-yellow pigment found in madder root (R.
- GC60314 Pyraclostrobin Pyraclostrobin is a strobilurin fungicide that inhibits mitochondrial complex III of fungal and mammalian cells.
- GC61818 Pyribencarb Pyribencarb is a benzylcarbamate-type fungicide, which is active against a wide range of plant pathogenic fungi.
- GC61755 Pyrimethanil Pyrimethanil is an?anilinopyrimidine?and broad-spectrum?contact fungicide for the control of Botrytis spp.
- GC32391 Pyrogallol A natural oxidant
- GC37061 Quilseconazole Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes.
- GC61666 Quinizarin Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM).
- GC32116 Ravuconazole (BMS-207147) Ravuconazole (BMS-207147) (BMS-207147;ER-30346) is an orally available triazoleantifungle agent that potently inhibits a wide range of fungi.
- GC41466 Reveromycin A Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp.
- GC60321 Rezafungin acetate Rezafungin acetate (Biafungin acetate) is a next-generation, broad-spectrum, and long-lasting echinocandin.
- GC61576 Robinetin Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity.
-
GC69829
Rolusafine
Rolusafine is an antifungal agent.
- GC39839 S.pombe lumazine synthase-IN-1 S.pombe lumazine synthase-IN-1 is an inhibitor of?lumazine synthases?with?Ki?values of 243 μM and 9.6 μM for?Schizosaccharomyces pombe?and?Mycobacterium tuberculosis?lumazine synthases, respectively.
-
GC34773
Sakuranetin
A flavonoid with diverse biological activities
- GC32374 Saperconazole (R66905) Saperconazole (R66905) (R66905) is a broad-spectrum antifungal triazole and has potent activity against Aspergillus with an MIC90 of 0.19 mg/L.
- GC68465 SDH-IN-1
- GC61465 SDZ285428 SDZ285428 is a CYP51 inhibitor.
- GC16757 Sertaconazole nitrate Broad-spectrum antifungal
- GC30646 Skatole(3-Methylindole) Skatole(3-Methylindole) is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
- GC38958 Sorbic acid Sorbic acid is a highly efficient, and nonpoisonous?food preservative.
- GC18644 Sordarin (sodium salt) Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties.
- GC32268 Stilbamidine (Ba 2652) Stilbamidine (Ba 2652) is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.
- GC32221 Sulbentine (Dibenzthione) Sulbentine (Dibenzthione) (Dibenzthione) is an azole antifungal agent that has fungistatic and fungicidal activities.
- GC11909 Sulconazole Nitrate Sulconazole Nitrate ((±)-Sulconazole Nitrate), an imidazole derivative, is a broad-spectrum fungicide.
- GC63675 T-2307 T-2307, an arylamidine, has antifungal activities in vitro and in vivo.
- GC32160 Tebuconazole A triazole fungicide
- GC17066 Terbinafine Allylamine antifungal agent
- GC14576 Terbinafine HCl Terbinafine HCl (TDT 067 hydrochloride) is an orally active and potent antifungal agent.
- GC32131 Terconazole (R42470) Terconazole (R42470) is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.
- GC65431 Tetradehydropodophyllotoxin Tetradehydropodophyllotoxin possesses antifungal activity.
- GC39098 Tetrahydroepiberberine Tetrahydroepiberberine is a isoquinoline alkaloid isolated from Corydalis impatiens (Pall).
- GC32150 Thifluzamide Thifluzamide, a broad-spectrum succinate dehydrogenase inhibitor (SDHI) fungicide, has been widely used in the controlling of a variety of fungal diseases in rice fields.
-
GC34839
Thiophanate-Methyl
Thiophanate-Methyl is a systematic fungicide.
- GC38951 Thymol iodide Thymol iodide is a compound of Iodide and Thymol.
- GC68144 Ticlatone
- GC14617 Tioconazole antifungal medication
- GC10337 Tolnaftate anti-fungal agent
- GC61896 trans-Chalcone trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor.
- GC33538 Triacetin (Glyceryl triacetate) Triacetin (Glyceryl triacetate) is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
- GC45078 Triadimefon Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees.
- GC45079 Triadimenol Triadimenol is a metabolite of triadimefon, a broad-spectrum chiral triazole fungicide, that is formed by reduction of a carbonyl group to the corresponding alcohol.
- GC13311 Triclosan broad-spectrum antibacterial agent
-
GC34845
Trifloxystrobin
A fungicide
- GC32041 Triphala Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica.
- GC45091 Triticonazole Triticonazole is a triazole fungicide used for the control of common soil and seed-borne diseases on cereals and other crops.
-
GC18414
Tyrothricin
Tyrothricin is a polypeptide antibiotic mixture produced by B.
- GC38246 Undecanoic acid Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T.
-
GC70093
Undecanoic acid-d21
Undecanoic acid-d21 is the deuterated form of Undecanoic acid. Undecanoic acid (Undecanoate) is a monocarboxylic acid with antifungal properties that can inhibit the production of keratinase and lipase in Trichophyton rubrum cells, as well as the biosynthesis of various phospholipids.
- GC45135 Validamycin A Validamycin A is an antifungal agent used to protect rice plants against sheath blight caused by the pathogenic fungus, R.