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Reuterin

Catalog No.: GC49790

Reuterin is a broad-spectrum antimicrobial agent active against Gram positive and Gram negative bacteria, as well as yeasts, moulds and protozoa.

Reuterin Chemical Structure

Size Price Stock Qty
25 mg
$82.60
In stock
50 mg
$148.40
In stock
100 mg
$264.60
In stock
250 mg
$537.60
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Reuterin is a glycerol metabolite originally isolated from L. reuteri, a bacteria found in the intestines of humans, that has antibacterial activity.1 It is produced by L. reuteri during exposure to live or UV-killed E. coli.2 Reuterin is active against E. coli and several species of Bacteroides, Bifidobacterium, and Eubacterium (MICs = 1.9-15 mM) as well as C. difficile and B. vulgatus (MICs = <1.9 mM for both).3 It enhances increases in the production of reactive oxygen species (ROS) and cell death induced by vancomycin or metronidazole in C. difficile when used at a concentration of 2.5 mM.4 Reuterin alters the bacterial composition of, and volatile organic compounds (VOCs) produced by, the mouse fecal microbiome.5

1.Talarico, T.L., Casas, I.A., Chung, T.C., et al.Production and isolation of reuterin, a growth inhibitor produced by Lactobacillus reuteriAntimicrob. Agents Chemother.32(12)1854-1858(1988) 2.Schaefer, L., Auchtung, T.A., Hermans, K.E., et al.The antimicrobial compound reuterin (3-hydroxypropionaldehyde) induces oxidative stress via interaction with thiol groupsMicrobiology (Reading)156(Pt 6)1589-1599(2010) 3.Cleusix, V., Lacroix, C., Vollenweider, S., et al.Inhibitory activity spectrum of reuterin produced by Lactobacillus reuteri against intestinal bacteriaBMC Microbiol.7101(2007) 4.Engevik, M.A., Danhof, H.A., Shrestha, R., et al.Reuterin disrupts Clostridioides difficile metabolism and pathogenicity through reactive oxygen species generationGut Microbes12(1)1788898(2020) 5.Castellani, C., ObermÜller, B., Kienesberger, B., et al.Production, storage stability, and susceptibility testing of reuterin and its impact on the murine fecal microbiome and volatile organic compound profileFront. Microbiol.12699858(2021)

Chemical Properties

Cas No. 2134-29-4 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=CCCO
Formula C3H6O2 M.Wt 74.1
Solubility DMF: 25 mg/mL,DMSO: 20 mg/mL,Ethanol: 16 mg/mL,PBS (pH 7.2): 5 mg/mL Storage -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 15 reference(s) in Google Scholar.)

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