Home>>Reversin 121
Reversin 121 Catalog No.GC44821

A hydrophobic peptide chemosensitizer

Size Price Stock Qty
500μg
$35.00
In stock
1mg
$60.00
In stock
5mg
$210.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 174630-04-7 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C(OCC1=CC=CC=C1)NCCCC[C@H](NC([C@H](CC(OCC2=CC=CC=C2)=O)NC(OC(C)(C)C)=O)=O)C(OC(C)(C)C)=O
Formula C34H47N3O9 M.Wt 641.8
Solubility DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 12 mg/ml Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a Kd value of 77 nM. Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma membrane vesicles from multidrug-resistant cells, and reconstituted proteoliposomes as well as in a variety of MDR1-expressing intact tumor cells.