Rhein-13C6 (Synonyms: Rheic Acid-13C6) |
| Catalog No.GC91920 |
Rhein-13C6 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Rhein-13C6 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anthraquinone derivative that has been found in R. rhabarbarum and is an active metabolite of diacerein that has diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities.1,2,3,4 It induces cell cycle arrest at the S phase and inhibits the proliferation of HepG2 cells when used at concentrations of 40 and 100 ?M, respectively.1 Rhein (100 and 200 ?M) also inhibits the proliferation of MCF-7 and MDA-MB-435s breast cancer cells under normoxic and hypoxic conditions.2 It reduces controlled cortical impact-induced decreases in catalase and superoxide dismutase (SOD) activity and malondialdehyde (MDA), glutathione, and glutathione disulfide levels in the brain in a rat model of traumatic brain injury when administered at a dose of 12 mg/kg.3 Rhein (50 mg/kg per day) reduces cerulein-induced increases in serum TNF-α, IL-1β, and amylase levels, as well as reduces pancreatic glandular atrophy and fibrosis, in a mouse model of chronic pancreatitis.4
References:
[1]. Liu, S., Wang, J., Shao, T., et al.The natural agent rhein induces β-catenin degradation and tumour growth arrestJ. Cell. Mol. Med.22(1)589-599(2018).
[2]. Fernand, V.E., Losso, J.N., Traux, R.E., et al.Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitroChem. Biol. Interact.192(3)220-232(2011).
[3]. Xu, X., Lv, H., Xia, Z., et al.Rhein exhibits antioxidative effects similar to Rhubarb in a rat model of traumatic brain injuryBMC Complement. Altern. Med.17(1)140(2017).
[4]. Tsang, S.W., Zhang, H., Lin, C., et al.Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitisPLoS One8(12)e82201(2013).
| Cas No. | SDF | ||
| Synonyms | Rheic Acid-13C6 | ||
| Chemical Name | 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid-1,2,3,4,4a,9a-13C6 | ||
| Canonical SMILES | O=C1[13C]2=[13C](O)[13CH]=[13C](C(O)=O)[13CH]=[13C]2C(C3=C1C(O)=CC=C3)=O | ||
| Formula | C9[13C]6H8O6 | M.Wt | 290.2 |
| Solubility | DMSO: Soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.4459 mL | 17.2295 mL | 34.459 mL |
| 5 mM | 0.6892 mL | 3.4459 mL | 6.8918 mL |
| 10 mM | 0.3446 mL | 1.7229 mL | 3.4459 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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