Ro 41-0960 |
| Catalog No.GC46213 |
A COMT inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 125628-97-9
Sample solution is provided at 25 µL, 10mM.
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Ro 41-0960 is a catechol-O-methyltransferase (COMT) inhibitor.1 It prevents dopaminergic neuron loss induced by L-DOPA in primary rat rostral mesencephalic tegmentum cultures (EC50 = 0.1 μM). Ro 41-0960 (30 mg/kg) potentiates L-DOPA and carbidopa-induced reversal of reserpine-induced akinesias in rats and reserpine-induced catalepsy and hypothermia in mice.2 It reduces striatal 3-methyl-DOPA levels and increases striatal dopamine and 3,4-dihydroxyphenylacetic acid levels in rats. Ro 41-0960 (150 mg/kg) also reduces fibroid volume in the Eker rat model of uterine fibroids.3
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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