Rose Bengal (Synonyms: Acid Red 94, Japan Red 105-1, Red No. 105-1) |
| Catalog No.GC15691 |
Rose Bengal, a synthetic fluorescein derivative, and is a crimson-coloured dye with the principal component being 4,5,6,7-tetrachloro-2,4,5,7-tetraiodo fluorescein.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 632-69-9
Sample solution is provided at 25 µL, 10mM.
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Ki: 19 and 64 nM for VGlut andVMAT, respectively
Rose Bengal is a potent VGlut and vesicular monoamine transporter (VMAT) inhibitor.
The common biochemical l-glutamate (Glu) is widely recognized as the major excitatory neurotransmitter in the vertebrate CNS. Proper Glu transmission plays a critical role in physiological brain functions, such as learning and memory formation as well as basic neural communication.
In vitro: Rose Bengal was a quite potent membrane-permeant inhibitor of glutamate uptake into isolated synaptic vesicles. Such vesicular Glu uptake inhibition was achieved without affecting H1-pump ATPase. It was found that various degrees of reduction elicited by Rose Bengal in [3H]Glu in synaptic vesicles inside the synaptosome [1].
In vivo: The distribution of i.v. administered rose bengal was found to depend on its dose. At a low dose, rose bengal could be found almost solely in the liver and plasma. However, at higher doses, the amount of rose bengal found in extra-hepatic tissues gradually increased. The hepatic transfer maximum of rose bengal amounted to 146 micrograms/kg/min. By increasing the dose from 10 to 200 mg/kg, the hepatic concentration of rose bengal also approached a maximum. The storage capacity of the liver, however, did not limit the transfer maximum of rose bengal [1].
Clinical trial: N/A
References:
[1] Ogita K,Hirata K,Bole DG,Yoshida S,Tamura Y,Leckenby AM,Ueda T. Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal. J Neurochem.2001 Apr;77(1):34-42.
[2] Fischer E,Varga F. Hepatic storage and biliary excretion of rose bengal in the rat. Acta Physiol Acad Sci Hung.1979;54(1):89-94.
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