Home>>(S)-(+)-Eicosapentaenyl-2'-Hydroxy-1'-Propylamide

(S)-(+)-Eicosapentaenyl-2'-Hydroxy-1'-Propylamide

Catalog No.GC41729

N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group.

Products are for research use only. Not for human use. We do not sell to patients.

(S)-(+)-Eicosapentaenyl-2'-Hydroxy-1'-Propylamide Chemical Structure

Size Price Stock
1mg
$111.00
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5mg
$502.00
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10mg
$891.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Eicosapentaenoyl ethanolamide (EPEA) has potential signaling roles in aging, cancer, inflammation, and neurological development. At least some of EPEA's effects are mediated through cannabinoid (CB) receptors, while some NAEs also act as vanilloid receptor agonists. S-(+)-Eicosapentaenyl-2'-hydroxy-1'-propylamide is a homolog of EPEA, characterized by the addition of an (S)-β-methyl group at the terminal ethanolamine carbon. A similar modification of arachidonoyl ethanolamide to produce S-2 methanandamide imparts higher affinity for the CB receptor. The physiological actions of this compound have not been evaluated.

Chemical Properties

Cas No. SDF
Canonical SMILES CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(NC[C@H](C)O)=O
Formula C23H37NO2 M.Wt 359.6
Solubility DMF: 11 mg/ml,DMSO: 10 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.7809 mL 13.9043 mL 27.8087 mL
5 mM 0.5562 mL 2.7809 mL 5.5617 mL
10 mM 0.2781 mL 1.3904 mL 2.7809 mL
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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for (S)-(+)-Eicosapentaenyl-2'-Hydroxy-1'-Propylamide

Average Rating: 5 ★★★★★ (Based on Reviews and 33 reference(s) in Google Scholar.)

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