SAH-EZH2 |
| Catalog No.GC50553 |
EZH2/EDD interaction inhibitor; suppresses PCR2 complex function
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1453222-26-8
Sample solution is provided at 25 µL, 10mM.
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EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.
Kim et al (2013) Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat.Chem.Biol. 9 643 PMID:23974116 |Kim et al (2015) SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nat.Med. 21 1491 PMID:26552009
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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