SAH-SOS1A |
| Catalog No.GC50609 |
KRas/SOS1 interaction inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1652561-87-9
Sample solution is provided at 25 µL, 10mM.
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KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.
Leshchiner et al (2015) Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices. Proc.Natl.Acad.Sci.USA. 112 1761 PMID:25624485
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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