Salvinorin B Mesylate (Synonyms: Mesyl Sal B) |
| Catalog No.GC44871 |
Salvinorin B mesylate (Mesyl Sal B) is a selective κ-opioid receptor agonist that is more potent than salvinorin A in CHO cells transfected with the human κ-opioid receptor (EC50s = 30 and 40 nM, respectively).
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Cas No.: 862073-79-8
Sample solution is provided at 25 µL, 10mM.
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Salvinorin B mesylate (Mesyl Sal B) is a selective κ-opioid receptor agonist that is more potent than salvinorin A in CHO cells transfected with the human κ-opioid receptor (EC50s = 30 and 40 nM, respectively). It is a mesylated version of salvinorin B and is highly selective for κ-opioid receptors over µ- and δ-opioid receptors. In vitro, it increases dopamine uptake via the dopamine transporter (DAT) in an ERK1/2-dependent manner but does not alter expression of DAT on the cell membrane. In rats, it increases the pain threshold and blocks reinstatement of cocaine drug-seeking.
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