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Saquinavir-d9

Catalog No.GC45974

An internal standard for the quantification of saquinavir

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Saquinavir-d9 Chemical Structure

Cas No.: 1356355-11-7

Size Price Stock Qty
1mg
$506.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Sauinavir-d9 is intended for use as an internal standard for the quantification of saquinavir by GC- or LC-MS. Saquinavir is an HIV protease inhibitor (Kis = 0.12 and <0.1 nM for HIV-1 and HIV-2 protease, respectively) that exhibits antiviral activity with low cytotoxicity.1,2 When co-administered with ritonavir , the bioavailability of saquinavir (20 mg/kg) has been shown to increase 325-fold in mice through a mechanism that inhibits its metabolism by CYP3A.3

|1. Roberts, N.A., Martin, J.A., Kinchington, D., et al. Rational design of peptide-based HIV proteinase inhibitors. Science 248(4953), 358-361 (1990).|2. Tucker, T.J., Lumma, W.C., Jr., Payne, L.S., et al. A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: Synthesis, enzyme inhibition, and antiviral activity. J. Med. Chem. 35(14), 2525-2533 (1992).|3. Tomaru, A., Takeda-Morishita, M., Banba, H., et al. Analysis of the pharmacokinetic boosting effects of ritonavir on oral bioavailability of drugs in mice. Drug Metab. Pharmacokinet. 28(2), 144-152 (2013).

Chemical Properties

Cas No. 1356355-11-7 SDF
Canonical SMILES O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN2C[C@](CCCC3)([H])[C@]3([H])C[C@H]2C(NC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=O)C4=NC(C=CC=C5)=C5C=C4
Formula C38H41D9N6O5 M.Wt 679.9
Solubility Chloroform: soluble,Methanol: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.4708 mL 7.354 mL 14.708 mL
5 mM 0.2942 mL 1.4708 mL 2.9416 mL
10 mM 0.1471 mL 0.7354 mL 1.4708 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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