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SARS-CoV-IN-3

Catalog No.GC39563

SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication.

Products are for research use only. Not for human use. We do not sell to patients.

SARS-CoV-IN-3 Chemical Structure

Cas No.: 888958-27-8

Size Price Stock Qty
10mM (in 1mL DMSO)
$652.00
In stock
5mg
$630.00
In stock
10mg
$927.00
In stock
50mg
$2,596.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 11.7 and 20.4 nM; and IC90s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC50 of 10 μM in MT-4 cells[1].

[1]. Biot C, et al. Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities. J Med Chem. 2006 May 4;49(9):2845-9.

Chemical Properties

Cas No. 888958-27-8 SDF
Canonical SMILES CCN(CCO)CC12=C3[Fe+2]1456789([C-]%10C6=C7C8=C9%10)[C-]2(CNC%11=CC=NC%12=C%11C=CC(Cl)=C%12)C4=C53
Formula C25H20ClFeN3O M.Wt 469.74
Solubility DMSO: 7.81 mg/mL (16.63 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.1288 mL 10.6442 mL 21.2884 mL
5 mM 0.4258 mL 2.1288 mL 4.2577 mL
10 mM 0.2129 mL 1.0644 mL 2.1288 mL
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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for SARS-CoV-IN-3

Average Rating: 5 ★★★★★ (Based on Reviews and 13 reference(s) in Google Scholar.)

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