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signal transducer and activator of transcription 6 fragment

Catalog No.GP10145

signal transducer and activator of transcription 6 fragment Chemical Structure

STAT6 transcription factor

Size Price Stock Qty
1mg
$33.00
In stock
5mg
$106.00
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10mg
$185.00
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25mg
$229.00
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Sample solution is provided at 25 µL, 10mM.

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Background

Signal transducer and activator of transcription 6 fragment, (C54H81N13O15), a peptide with the sequence H2N-Ser-Tyr-Trp-Ser-Asp-Arg-Leu-Ile-Ile-OH, MW= 1152.3. STAT6 is a member of the STAT family of transcription factors[1]. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators[2]. This protein plays a central role in exerting IL4 mediated biological responses[3]. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.


References:
1. Leek JP, Hamlin PJ, BellSM, LenchNJ(1997). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization". Cytogenet. Cell Genet. 79 (3–4): 208–9.
2. Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene 285 (1–2): 1–24.
3. Shimoda K, van Deursen J, Sangster MY, et al. (1996). "Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene". Nature 380 (6575): 630–3.

Chemical Properties

Cas No. N/A SDF
Synonyms H2N-Ser-Tyr-Trp-Ser-Asp-Arg-Leu-Ile-Ile-OH
Chemical Name N/A
Canonical SMILES OCC(N)C(NC(CC1=CC=C(O)C=C1)C(NC(CC2=CNC3=C2C=CC=C3)C(NC(CO)C(NC(CC(O)=O)C(NC(CCCNC(N)=N)C(NC(CC(C)C)C(NC(C(C)CC)C(NC(C(CC)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Formula C54H81N13O15 M.Wt 1152.3
Solubility ≥ 115.2mg/mL in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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