SIKVAV (acetate) (Synonyms: Hexapeptide-10, Ser-Ile-Lys-Val-Ala-Val) |
| Catalog No.GC49713 |
A laminin α1-derived peptide
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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SIKVAV is a laminin α1-derived peptide.1 It binds to α3, α6, and β1 integrins and induces adhesion of CAC2 adenoid cystic carcinoma cells when used at a concentration of 1 µg/ml. SIKVAV (100 µg/ml) stimulates the proliferation and migration of primary mouse fibroblasts, as well as induces the secretion of EGF, VEGF, TGF-β, and FGF in the same cells.2 Topical administration of a chitosan hydrogel containing SIKVAV promotes wound healing and angiogenesis in mice.
1.Freitas, V.M., Vilas-Boas, V.F., Pimenta, D.C., et al.SIKVAV, a laminin α1-derived peptide, interacts with integrins and increases protease activity of a human salivary gland adenoid cystic carcinoma cell line through the ERK 1/2 signaling pathwayAm. J. Pathol.171(1)124-138(2007) 2.Chen, X., Zhang, M., Chen, S., et al.Peptide-modified chitosan hydrogels accelerate skin wound healing by promoting fibroblast proliferation, migration, and secretionCell Transplant.26(8)1331-1340(2017)
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