SK 609 |
Catalog No.GC50644 |
Dopamine D3 receptor biased agonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1092797-77-7
Sample solution is provided at 25 µL, 10mM.
Dopamine D3 receptor biased agonist. Preferentially signals via the G protein-dependent pathway (EC50 values for G protein and β-arrestin-dependent signaling are 1.1 and 50.2 μM, respectively). Exhibits selectivity for D3 over D2 receptors. Improves motor deficits in rodent Parkinson's disease models and ameliorates L-DOPA induced abnormal involuntary movements.
Xu et al (2017) Functional characterization of a novel series of biased signaling dopamine D3 receptor agonists. ACS Chem.Neurosci. 8 486 PMID:27801563 |Simms et al (2016) In vivo characterization of a novel dopamine D3 receptor agonist to treat motor symptoms of Parkinson's disease. Neuropharmacology 100 106 PMID:25896768
Average Rating: 5
(Based on Reviews and 19 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *