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SK1-IN-1 Catalog No.GC33836

Size Price Stock Qty
10mM*1mLinDMSO
$282.00
In stock
1mg
$138.00
In stock
5mg
$321.00
In stock
10mg
$552.00
In stock
25mg
$1,103.00
In stock
50mg
$1,747.00
In stock
100mg
$2,574.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

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Chemical Properties

Cas No. 1218816-71-7 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C([C@H]1NCC[C@@H]1O)N[C@H](C2=CC=C(C3=NOC(CCC4CCCC4)=N3)C=C2)C
Formula C22H30N4O3 M.Wt 398.5
Solubility DMSO : ≥ 100 mg/mL (250.94 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.

SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation[1].

[1]. Xiang Y, et al. Discovery of novel sphingosine kinase-1 inhibitors. Part 2. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4550-4.