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SKF-82958 hydrobromide ((±)-SKF 82958 hydrobromide) Catalog No.GC33664

Size Price Stock Qty
10mM*1mLinDMSO
$100.00
In stock
5mg
$91.00
In stock
10mg
$147.00
In stock
25mg
$295.00
In stock
50mg
$534.00
In stock
100mg
$965.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Chemical Properties

Cas No. 74115-01-8 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES OC1=C(O)C=C2C(C3=CC=CC=C3)CN(CC=C)CCC2=C1Cl.[H]Br
Formula C19H21BrClNO2 M.Wt 410.73
Solubility DMSO : ≥ 102.5 mg/mL (249.56 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

SKF 82958 hydrobromide is a D1/D5 receptor full agonist. IC50 value:Target: D1/D5 receptorin vitro: Neuropeptide and immediate early gene expression in striatonigral neurons of the normosensitive striatum is induced by mixed D1 receptor SKF-82958, which induces behavioral activity and preprodynorphin (PPD) and substance P (SP) gene expression in medium spiny neurons in the dorsal, and especially, in the ventral striatum. in vivo:Quantitative in situ hybridization was used to examine the contribution of muscarinic receptors to the transynaptic regulation of striatal gene expression induced by D1receptor activation. The acute injection of the full D1 agonist, SKF-82958, would induce PPD, SP and PPE mRNA expression in the intact rat striatum.

[1]. Wang JQ, et al. The Full D1 Dopamine Receptor Agonist SKF-82958 Induces Neuropeptide mRNA in the Normosensitive Striatum of Rats: Regulation of D1/D2 Interactions by Muscarinic Receptors.J Pharmacol Exp Ther. 1997 May;281(2):972-82.